Cochineal dye-induced immediate allergy: Review of Japanese cases and proposed new diagnostic chart

Naoko Takeo, Masashi Nakamura, Satoshi Nakayama, Osamu Okamoto, Naoki Sugimoto, Shinichi Sugiura, Nayu Sato, Susumu Harada, Masao Yamaguchi, Naoya Mitsui, Yumiko Kubota, Kayoko Suzuki, Makoto Terada, Akiyo Nagai, Junko Sowa-Osako, Yutaka Hatano, Hiroshi Akiyama, Akiko Yagami, Sakuhei Fujiwara, Kayoko Matsunaga

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. CA and carmine usually contain contaminating proteins, including a 38-kDa protein thought to be the primary allergen. Severe allergic reactions manifest as anaphylaxis. The aim of this study was to review all Japanese reported cases and propose useful diagnostic chart. Methods: All reported Japanese cases of cochineal dye-induced immediate allergy were reviewed, and newly registered cases were examined by skin prick test (SPT) with cochineal extract (CE) and measurement of CE and carmine-specific serum IgE test. Two-dimensional (2D) western blotting using patient serum was conducted to identify the antigen. Results: Twenty-two Japanese cases have been reported. SPT and the level of specific IgE test indicated that six cases should be newly registered as cochineal dye allergy. All cases were adult females, and all cases except three involved anaphylaxis; 13 cases involved past history of local symptoms associated with cosmetics use. Japanese strawberry juice and fish-meat sausage, and European processed foods (especially macarons made in France) and drinks were recent major sources of allergen. 2D western blotting showed that patient IgE reacted to the 38-kDa protein and other proteins. Serum from healthy controls also weakly reacted with these proteins. Conclusions: SPT with CE and determination of the level of CE and carmine-specific IgE test are useful methods for the diagnosis of cochineal dye allergy.

Original languageEnglish
Pages (from-to)496-505
Number of pages10
JournalAllergology International
Volume67
Issue number4
DOIs
Publication statusPublished - 01-10-2018

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Carmine
Hypersensitivity
Immunoglobulin E
Skin Tests
Anaphylaxis
Proteins
Cosmetics
Allergens
Western Blotting
Serum
Food
Fragaria
Aluminum
Pharmaceutical Preparations
Meat
France

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Takeo, N., Nakamura, M., Nakayama, S., Okamoto, O., Sugimoto, N., Sugiura, S., ... Matsunaga, K. (2018). Cochineal dye-induced immediate allergy: Review of Japanese cases and proposed new diagnostic chart. Allergology International, 67(4), 496-505. https://doi.org/10.1016/j.alit.2018.02.012
Takeo, Naoko ; Nakamura, Masashi ; Nakayama, Satoshi ; Okamoto, Osamu ; Sugimoto, Naoki ; Sugiura, Shinichi ; Sato, Nayu ; Harada, Susumu ; Yamaguchi, Masao ; Mitsui, Naoya ; Kubota, Yumiko ; Suzuki, Kayoko ; Terada, Makoto ; Nagai, Akiyo ; Sowa-Osako, Junko ; Hatano, Yutaka ; Akiyama, Hiroshi ; Yagami, Akiko ; Fujiwara, Sakuhei ; Matsunaga, Kayoko. / Cochineal dye-induced immediate allergy : Review of Japanese cases and proposed new diagnostic chart. In: Allergology International. 2018 ; Vol. 67, No. 4. pp. 496-505.
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abstract = "Background: Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. CA and carmine usually contain contaminating proteins, including a 38-kDa protein thought to be the primary allergen. Severe allergic reactions manifest as anaphylaxis. The aim of this study was to review all Japanese reported cases and propose useful diagnostic chart. Methods: All reported Japanese cases of cochineal dye-induced immediate allergy were reviewed, and newly registered cases were examined by skin prick test (SPT) with cochineal extract (CE) and measurement of CE and carmine-specific serum IgE test. Two-dimensional (2D) western blotting using patient serum was conducted to identify the antigen. Results: Twenty-two Japanese cases have been reported. SPT and the level of specific IgE test indicated that six cases should be newly registered as cochineal dye allergy. All cases were adult females, and all cases except three involved anaphylaxis; 13 cases involved past history of local symptoms associated with cosmetics use. Japanese strawberry juice and fish-meat sausage, and European processed foods (especially macarons made in France) and drinks were recent major sources of allergen. 2D western blotting showed that patient IgE reacted to the 38-kDa protein and other proteins. Serum from healthy controls also weakly reacted with these proteins. Conclusions: SPT with CE and determination of the level of CE and carmine-specific IgE test are useful methods for the diagnosis of cochineal dye allergy.",
author = "Naoko Takeo and Masashi Nakamura and Satoshi Nakayama and Osamu Okamoto and Naoki Sugimoto and Shinichi Sugiura and Nayu Sato and Susumu Harada and Masao Yamaguchi and Naoya Mitsui and Yumiko Kubota and Kayoko Suzuki and Makoto Terada and Akiyo Nagai and Junko Sowa-Osako and Yutaka Hatano and Hiroshi Akiyama and Akiko Yagami and Sakuhei Fujiwara and Kayoko Matsunaga",
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Takeo, N, Nakamura, M, Nakayama, S, Okamoto, O, Sugimoto, N, Sugiura, S, Sato, N, Harada, S, Yamaguchi, M, Mitsui, N, Kubota, Y, Suzuki, K, Terada, M, Nagai, A, Sowa-Osako, J, Hatano, Y, Akiyama, H, Yagami, A, Fujiwara, S & Matsunaga, K 2018, 'Cochineal dye-induced immediate allergy: Review of Japanese cases and proposed new diagnostic chart', Allergology International, vol. 67, no. 4, pp. 496-505. https://doi.org/10.1016/j.alit.2018.02.012

Cochineal dye-induced immediate allergy : Review of Japanese cases and proposed new diagnostic chart. / Takeo, Naoko; Nakamura, Masashi; Nakayama, Satoshi; Okamoto, Osamu; Sugimoto, Naoki; Sugiura, Shinichi; Sato, Nayu; Harada, Susumu; Yamaguchi, Masao; Mitsui, Naoya; Kubota, Yumiko; Suzuki, Kayoko; Terada, Makoto; Nagai, Akiyo; Sowa-Osako, Junko; Hatano, Yutaka; Akiyama, Hiroshi; Yagami, Akiko; Fujiwara, Sakuhei; Matsunaga, Kayoko.

In: Allergology International, Vol. 67, No. 4, 01.10.2018, p. 496-505.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cochineal dye-induced immediate allergy

T2 - Review of Japanese cases and proposed new diagnostic chart

AU - Takeo, Naoko

AU - Nakamura, Masashi

AU - Nakayama, Satoshi

AU - Okamoto, Osamu

AU - Sugimoto, Naoki

AU - Sugiura, Shinichi

AU - Sato, Nayu

AU - Harada, Susumu

AU - Yamaguchi, Masao

AU - Mitsui, Naoya

AU - Kubota, Yumiko

AU - Suzuki, Kayoko

AU - Terada, Makoto

AU - Nagai, Akiyo

AU - Sowa-Osako, Junko

AU - Hatano, Yutaka

AU - Akiyama, Hiroshi

AU - Yagami, Akiko

AU - Fujiwara, Sakuhei

AU - Matsunaga, Kayoko

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. CA and carmine usually contain contaminating proteins, including a 38-kDa protein thought to be the primary allergen. Severe allergic reactions manifest as anaphylaxis. The aim of this study was to review all Japanese reported cases and propose useful diagnostic chart. Methods: All reported Japanese cases of cochineal dye-induced immediate allergy were reviewed, and newly registered cases were examined by skin prick test (SPT) with cochineal extract (CE) and measurement of CE and carmine-specific serum IgE test. Two-dimensional (2D) western blotting using patient serum was conducted to identify the antigen. Results: Twenty-two Japanese cases have been reported. SPT and the level of specific IgE test indicated that six cases should be newly registered as cochineal dye allergy. All cases were adult females, and all cases except three involved anaphylaxis; 13 cases involved past history of local symptoms associated with cosmetics use. Japanese strawberry juice and fish-meat sausage, and European processed foods (especially macarons made in France) and drinks were recent major sources of allergen. 2D western blotting showed that patient IgE reacted to the 38-kDa protein and other proteins. Serum from healthy controls also weakly reacted with these proteins. Conclusions: SPT with CE and determination of the level of CE and carmine-specific IgE test are useful methods for the diagnosis of cochineal dye allergy.

AB - Background: Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. CA and carmine usually contain contaminating proteins, including a 38-kDa protein thought to be the primary allergen. Severe allergic reactions manifest as anaphylaxis. The aim of this study was to review all Japanese reported cases and propose useful diagnostic chart. Methods: All reported Japanese cases of cochineal dye-induced immediate allergy were reviewed, and newly registered cases were examined by skin prick test (SPT) with cochineal extract (CE) and measurement of CE and carmine-specific serum IgE test. Two-dimensional (2D) western blotting using patient serum was conducted to identify the antigen. Results: Twenty-two Japanese cases have been reported. SPT and the level of specific IgE test indicated that six cases should be newly registered as cochineal dye allergy. All cases were adult females, and all cases except three involved anaphylaxis; 13 cases involved past history of local symptoms associated with cosmetics use. Japanese strawberry juice and fish-meat sausage, and European processed foods (especially macarons made in France) and drinks were recent major sources of allergen. 2D western blotting showed that patient IgE reacted to the 38-kDa protein and other proteins. Serum from healthy controls also weakly reacted with these proteins. Conclusions: SPT with CE and determination of the level of CE and carmine-specific IgE test are useful methods for the diagnosis of cochineal dye allergy.

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U2 - 10.1016/j.alit.2018.02.012

DO - 10.1016/j.alit.2018.02.012

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SP - 496

EP - 505

JO - Allergology International

JF - Allergology International

SN - 1323-8930

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