TY - JOUR
T1 - Coffee consumption and risk of colorectal cancer
T2 - The Japan collaborative cohort study
AU - For the JACC Study Group
AU - Yamada, Hiroya
AU - Kawado, Miyuki
AU - Aoyama, Norihiro
AU - Hashimoto, Shuji
AU - Suzuki, Koji
AU - Wakai, Kenji
AU - Suzuki, Sadao
AU - Watanabe, Yoshiyuki
AU - Tamakoshi, Akiko
AU - Mori, Mitsuru
AU - Sakauchi, Fumio
AU - Motohashi, Yutaka
AU - Tsuji, Ichiro
AU - Nakamura, Yosikazu
AU - Iso, Hiroyasu
AU - Mikami, Haruo
AU - Kurosawa, Michiko
AU - Hoshiyama, Yoshiharu
AU - Tanabe, Naohito
AU - Tamakoshi, Koji
AU - Tokudome, Shinkan
AU - Kikuchi, Shogo
AU - Wada, Yasuhiko
AU - Kawamura, Takashi
AU - Ozasa, Kotaro
AU - Miki, Tsuneharu
AU - Date, Chigusa
AU - Sakata, Kiyomi
AU - Kurozawa, Yoichi
AU - Yoshimura, Takesumi
AU - Fujino, Yoshihisa
AU - Shibata, Akira
AU - Okamoto, Naoyuki
AU - Shio, Hideo
N1 - Publisher Copyright:
© 2014 Hiroya Yamada et al.
PY - 2014
Y1 - 2014
N2 - Background: Epidemiologic studies have reported coffee consumption to be associated with various health conditions. The purpose of this study was to examine the relationship of coffee consumption with colorectal cancer incidence in a large-scale prospective cohort study in Japan. Methods: We used data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). Here, we analyzed a total of 58 221 persons (23 607 men, 34 614 women) followed from 1988 to the end of 2009. During 738 669 person-years of follow-up for the analysis of colorectal cancer risk with coffee consumption at baseline, we identified 687 cases of colon cancer (355 males and 332 females) and 314 cases of rectal cancer (202 males and 112 females). We used the Cox proportional-hazard regression model to estimate hazard ratio (HR). Results: Compared to those who consumed less than 1 cup of coffee per day, men who consumed 2-3 cups of coffee per day had an HR of 1.26 (95% confidence interval [CI] 0.93-1.70), and men who consumed more than 4 cups of coffee per day had an HR of 1.79 (95% CI 1.01-3.18). A statistically significant increase in the risk of colon cancer was associated with increasing coffee consumption among men (P for trend = 0.03). On the other hand, coffee consumption in women was not associated with incident risk of colon cancer. Coffee consumption was also not associated with rectal cancer incidence in men or women. Conclusions: This large-scale population-based cohort study showed that coffee consumption increases the risk of colon cancer among Japanese men.
AB - Background: Epidemiologic studies have reported coffee consumption to be associated with various health conditions. The purpose of this study was to examine the relationship of coffee consumption with colorectal cancer incidence in a large-scale prospective cohort study in Japan. Methods: We used data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). Here, we analyzed a total of 58 221 persons (23 607 men, 34 614 women) followed from 1988 to the end of 2009. During 738 669 person-years of follow-up for the analysis of colorectal cancer risk with coffee consumption at baseline, we identified 687 cases of colon cancer (355 males and 332 females) and 314 cases of rectal cancer (202 males and 112 females). We used the Cox proportional-hazard regression model to estimate hazard ratio (HR). Results: Compared to those who consumed less than 1 cup of coffee per day, men who consumed 2-3 cups of coffee per day had an HR of 1.26 (95% confidence interval [CI] 0.93-1.70), and men who consumed more than 4 cups of coffee per day had an HR of 1.79 (95% CI 1.01-3.18). A statistically significant increase in the risk of colon cancer was associated with increasing coffee consumption among men (P for trend = 0.03). On the other hand, coffee consumption in women was not associated with incident risk of colon cancer. Coffee consumption was also not associated with rectal cancer incidence in men or women. Conclusions: This large-scale population-based cohort study showed that coffee consumption increases the risk of colon cancer among Japanese men.
KW - Coffee
KW - Colorectal cancer
KW - Incidence
KW - Prospective study
KW - The Japan collaborative cohort study
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U2 - 10.2188/jea.JE20130168
DO - 10.2188/jea.JE20130168
M3 - Article
C2 - 24857957
AN - SCOPUS:84921635559
SN - 0917-5040
VL - 24
SP - 370
EP - 378
JO - Journal of epidemiology
JF - Journal of epidemiology
IS - 5
ER -