Coffee consumption and the risk of prostate cancer: The Ohsaki Cohort Study

Q. Li, M. Kakizaki, Y. Sugawara, Y. Tomata, T. Watanabe, Y. Nishino, I. Tsuji

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Epidemiological evidence regarding the effect of coffee on the incidence of prostate cancer is inconsistent. We aimed to investigate coffee consumption and the risk of prostate cancer risk in a general Japanese population. Methods: We conducted a prospective cohort study in Ohsaki city, Japan, where 18 853 men aged 40-79 years participated in a baseline survey. Coffee consumption was assessed via a validated self-administered questionnaire. During 11 years of follow-up (from January 1 1995 to December 31, 2005), 318 incident cases of prostate cancer were detected. The Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs). Results: There was a significant inverse association between coffee consumption and the incidence risk of prostate cancer. Compared with those who did not drink coffee, the multivariate adjusted HRs were 0.81 (95% CI: 0.61-1.07), 0.73 (95% CI: 0.53-1.00), and 0.63 (095% CI: 0.39-1.00) for those who drank coffee occasionally, 1-2 cups per day, and ≥3 cups per day, respectively, with a P for trend of 0.02. Conclusion: This prospective finding from a Japanese population adds evidence that coffee intake is inversely associated with the incidence of prostate cancer.

Original languageEnglish
Pages (from-to)2381-2389
Number of pages9
JournalBritish Journal of Cancer
Volume108
Issue number11
DOIs
Publication statusPublished - 11-06-2013

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Coffee
Prostatic Neoplasms
Cohort Studies
Confidence Intervals
Incidence
Proportional Hazards Models
Population
Japan
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Li, Q., Kakizaki, M., Sugawara, Y., Tomata, Y., Watanabe, T., Nishino, Y., & Tsuji, I. (2013). Coffee consumption and the risk of prostate cancer: The Ohsaki Cohort Study. British Journal of Cancer, 108(11), 2381-2389. https://doi.org/10.1038/bjc.2013.238
Li, Q. ; Kakizaki, M. ; Sugawara, Y. ; Tomata, Y. ; Watanabe, T. ; Nishino, Y. ; Tsuji, I. / Coffee consumption and the risk of prostate cancer : The Ohsaki Cohort Study. In: British Journal of Cancer. 2013 ; Vol. 108, No. 11. pp. 2381-2389.
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abstract = "Background: Epidemiological evidence regarding the effect of coffee on the incidence of prostate cancer is inconsistent. We aimed to investigate coffee consumption and the risk of prostate cancer risk in a general Japanese population. Methods: We conducted a prospective cohort study in Ohsaki city, Japan, where 18 853 men aged 40-79 years participated in a baseline survey. Coffee consumption was assessed via a validated self-administered questionnaire. During 11 years of follow-up (from January 1 1995 to December 31, 2005), 318 incident cases of prostate cancer were detected. The Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95{\%} confidence interval (CIs). Results: There was a significant inverse association between coffee consumption and the incidence risk of prostate cancer. Compared with those who did not drink coffee, the multivariate adjusted HRs were 0.81 (95{\%} CI: 0.61-1.07), 0.73 (95{\%} CI: 0.53-1.00), and 0.63 (095{\%} CI: 0.39-1.00) for those who drank coffee occasionally, 1-2 cups per day, and ≥3 cups per day, respectively, with a P for trend of 0.02. Conclusion: This prospective finding from a Japanese population adds evidence that coffee intake is inversely associated with the incidence of prostate cancer.",
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Li, Q, Kakizaki, M, Sugawara, Y, Tomata, Y, Watanabe, T, Nishino, Y & Tsuji, I 2013, 'Coffee consumption and the risk of prostate cancer: The Ohsaki Cohort Study', British Journal of Cancer, vol. 108, no. 11, pp. 2381-2389. https://doi.org/10.1038/bjc.2013.238

Coffee consumption and the risk of prostate cancer : The Ohsaki Cohort Study. / Li, Q.; Kakizaki, M.; Sugawara, Y.; Tomata, Y.; Watanabe, T.; Nishino, Y.; Tsuji, I.

In: British Journal of Cancer, Vol. 108, No. 11, 11.06.2013, p. 2381-2389.

Research output: Contribution to journalArticle

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T1 - Coffee consumption and the risk of prostate cancer

T2 - The Ohsaki Cohort Study

AU - Li, Q.

AU - Kakizaki, M.

AU - Sugawara, Y.

AU - Tomata, Y.

AU - Watanabe, T.

AU - Nishino, Y.

AU - Tsuji, I.

PY - 2013/6/11

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N2 - Background: Epidemiological evidence regarding the effect of coffee on the incidence of prostate cancer is inconsistent. We aimed to investigate coffee consumption and the risk of prostate cancer risk in a general Japanese population. Methods: We conducted a prospective cohort study in Ohsaki city, Japan, where 18 853 men aged 40-79 years participated in a baseline survey. Coffee consumption was assessed via a validated self-administered questionnaire. During 11 years of follow-up (from January 1 1995 to December 31, 2005), 318 incident cases of prostate cancer were detected. The Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs). Results: There was a significant inverse association between coffee consumption and the incidence risk of prostate cancer. Compared with those who did not drink coffee, the multivariate adjusted HRs were 0.81 (95% CI: 0.61-1.07), 0.73 (95% CI: 0.53-1.00), and 0.63 (095% CI: 0.39-1.00) for those who drank coffee occasionally, 1-2 cups per day, and ≥3 cups per day, respectively, with a P for trend of 0.02. Conclusion: This prospective finding from a Japanese population adds evidence that coffee intake is inversely associated with the incidence of prostate cancer.

AB - Background: Epidemiological evidence regarding the effect of coffee on the incidence of prostate cancer is inconsistent. We aimed to investigate coffee consumption and the risk of prostate cancer risk in a general Japanese population. Methods: We conducted a prospective cohort study in Ohsaki city, Japan, where 18 853 men aged 40-79 years participated in a baseline survey. Coffee consumption was assessed via a validated self-administered questionnaire. During 11 years of follow-up (from January 1 1995 to December 31, 2005), 318 incident cases of prostate cancer were detected. The Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs). Results: There was a significant inverse association between coffee consumption and the incidence risk of prostate cancer. Compared with those who did not drink coffee, the multivariate adjusted HRs were 0.81 (95% CI: 0.61-1.07), 0.73 (95% CI: 0.53-1.00), and 0.63 (095% CI: 0.39-1.00) for those who drank coffee occasionally, 1-2 cups per day, and ≥3 cups per day, respectively, with a P for trend of 0.02. Conclusion: This prospective finding from a Japanese population adds evidence that coffee intake is inversely associated with the incidence of prostate cancer.

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