TY - JOUR
T1 - Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction
AU - Nasruddin,
AU - Nakajima, Yukari
AU - Mukai, Kanae
AU - Rahayu, Heni Setyowati Esti
AU - Nur, Muhammad
AU - Ishijima, Tatsuo
AU - Enomoto, Hiroshi
AU - Uesugi, Yoshihiko
AU - Sugama, Junko
AU - Nakatani, Toshio
N1 - Funding Information:
Part of this work was supported by Grants-in-Aid for Scientific Research, Japan (nos. 22592363 and 25293430 ) and a Grant from The Mitani Foundation for Research and Development .
Funding Information:
Nasruddin would like to acknowledge the help of the Directorate General of Higher Education (DIKTI), Indonesia, which supported him financially during his Ph.D. study through the Joint Scholarship Program DIKTI, Indonesia-Kanazawa University, Japan.
PY - 2014/7
Y1 - 2014/7
N2 - We investigated cold plasma effects on acute wounds of mice. The mice were classified into experimental and control groups. In the former, wounds were treated using cold plasma once daily for 1. min, and then covered with hydrocolloid dressing; wounds in the control were left to heal under hydrocolloid dressing. Daily evaluation was conducted for 15 days. General and specific staining was applied to evaluate re-epithelialization, neutrophil, macrophage, myofibroblast and transforming growth factor beta. It was found that cold plasma accelerated wound healing by 1 day. Plasma may promote the late phase of inflammation, accelerate re-epithelialization and increase wound contraction.
AB - We investigated cold plasma effects on acute wounds of mice. The mice were classified into experimental and control groups. In the former, wounds were treated using cold plasma once daily for 1. min, and then covered with hydrocolloid dressing; wounds in the control were left to heal under hydrocolloid dressing. Daily evaluation was conducted for 15 days. General and specific staining was applied to evaluate re-epithelialization, neutrophil, macrophage, myofibroblast and transforming growth factor beta. It was found that cold plasma accelerated wound healing by 1 day. Plasma may promote the late phase of inflammation, accelerate re-epithelialization and increase wound contraction.
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U2 - 10.1016/j.cpme.2014.01.001
DO - 10.1016/j.cpme.2014.01.001
M3 - Article
AN - SCOPUS:84906935332
SN - 2212-8166
VL - 2
SP - 28
EP - 35
JO - Clinical Plasma Medicine
JF - Clinical Plasma Medicine
IS - 1
ER -