Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Nasruddin, Yukari Nakajima, Kanae Mukai, Heni Setyowati Esti Rahayu, Muhammad Nur, Tatsuo Ishijima, Hiroshi Enomoto, Yoshihiko Uesugi, Junko Sugama, Toshio Nakatani

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

We investigated cold plasma effects on acute wounds of mice. The mice were classified into experimental and control groups. In the former, wounds were treated using cold plasma once daily for 1. min, and then covered with hydrocolloid dressing; wounds in the control were left to heal under hydrocolloid dressing. Daily evaluation was conducted for 15 days. General and specific staining was applied to evaluate re-epithelialization, neutrophil, macrophage, myofibroblast and transforming growth factor beta. It was found that cold plasma accelerated wound healing by 1 day. Plasma may promote the late phase of inflammation, accelerate re-epithelialization and increase wound contraction.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalClinical Plasma Medicine
Volume2
Issue number1
DOIs
Publication statusPublished - 07-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

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