Coloretal cancer and serum C-reactive protein levels: A case-control study nested in the JACC study

Yoshinori Ito, Koji Suzuki, Koji Tamakoshi, Kenji Wakai, Masayo Kojima, Kotaro Ozasa, Yoshiyuki Watanabe, Miyuki Kawado, Shuji Hashimoto, Sadao Suzuki, Sinkan Tokudome, Hideaki Toyoshima, Norihiko Hayakawa, Kazuo Kato, Makoto Watanabe, Yoshiji Ohta, Morito Maruta, Akiko Tamakoshi, Mitsuru Mori, Yutaka MotohashiIchiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Harou Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kukori, Kazuo Tajima

Research output: Contribution to journalArticle

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Abstract

Background: Recently, it has been hypothesized that inflammation increases the risk of colorectal cancer. We investigated whether serum levels of C-reactive protein (CRP), a biomarker of inflammation, are associated with colorectal cancer, using serum samples collected in the Japan Collaborative Cohort Study (JACC Study). Methods: We conducted a nested case-control study in the JACC Study, investigating the relationship between the risk for colorectal cancer and serum levels of CRP determined by a high-sensitivity CRP enzyme immunoassay. The subjects recruited were 141 patients with colorectal cancer (63 males and 78 females) and 327 controls with no history of cancer (148 males and 179 females). Each case of colorectal cancer was matched for sex, age and participating institution to 2 or 3 controls. We used t-test to analyze mean differences in CRP levels between colorectal cancer cases and controls. Odds ratios (ORs) and their 95% confidence intervals (Cls) were calculated using a conditional logistic regression model after adjusting for the potential confounding factors. Results: Serum CRP levels were not clearly associated with the risk of colorectal cancer. The OR of the highest serum CRP levels was 1.18 (95% Cl: 0.68-2.06) for colorectal cancer and 1.42 (95% Cl: 0.73-2.74) for colon cancer, compared to subjects with lowest serum levels. The OR for incidence of colorectal cancer showed a similar trend, but the difference was not significant. Thus, high serum CRP levels did not appear to increase the risk of colorectal cancer. Conclusions: The present results suggest that high serum CRP levels are not associated with the risk of colorectal cancer in the JACC Study.

Original languageEnglish
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

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C-Reactive Protein
Case-Control Studies
Blood Proteins
Colorectal Neoplasms
Neoplasms
Japan
Cohort Studies
Odds Ratio
Serum
Logistic Models
Inflammation
Immunoenzyme Techniques
Colonic Neoplasms
Biomarkers
Confidence Intervals
Incidence

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Ito, Yoshinori ; Suzuki, Koji ; Tamakoshi, Koji ; Wakai, Kenji ; Kojima, Masayo ; Ozasa, Kotaro ; Watanabe, Yoshiyuki ; Kawado, Miyuki ; Hashimoto, Shuji ; Suzuki, Sadao ; Tokudome, Sinkan ; Toyoshima, Hideaki ; Hayakawa, Norihiko ; Kato, Kazuo ; Watanabe, Makoto ; Ohta, Yoshiji ; Maruta, Morito ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Harou ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kukori, Toshio ; Tajima, Kazuo. / Coloretal cancer and serum C-reactive protein levels : A case-control study nested in the JACC study. In: Journal of epidemiology. 2005 ; Vol. 15, No. SUPPL. 2.
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abstract = "Background: Recently, it has been hypothesized that inflammation increases the risk of colorectal cancer. We investigated whether serum levels of C-reactive protein (CRP), a biomarker of inflammation, are associated with colorectal cancer, using serum samples collected in the Japan Collaborative Cohort Study (JACC Study). Methods: We conducted a nested case-control study in the JACC Study, investigating the relationship between the risk for colorectal cancer and serum levels of CRP determined by a high-sensitivity CRP enzyme immunoassay. The subjects recruited were 141 patients with colorectal cancer (63 males and 78 females) and 327 controls with no history of cancer (148 males and 179 females). Each case of colorectal cancer was matched for sex, age and participating institution to 2 or 3 controls. We used t-test to analyze mean differences in CRP levels between colorectal cancer cases and controls. Odds ratios (ORs) and their 95{\%} confidence intervals (Cls) were calculated using a conditional logistic regression model after adjusting for the potential confounding factors. Results: Serum CRP levels were not clearly associated with the risk of colorectal cancer. The OR of the highest serum CRP levels was 1.18 (95{\%} Cl: 0.68-2.06) for colorectal cancer and 1.42 (95{\%} Cl: 0.73-2.74) for colon cancer, compared to subjects with lowest serum levels. The OR for incidence of colorectal cancer showed a similar trend, but the difference was not significant. Thus, high serum CRP levels did not appear to increase the risk of colorectal cancer. Conclusions: The present results suggest that high serum CRP levels are not associated with the risk of colorectal cancer in the JACC Study.",
author = "Yoshinori Ito and Koji Suzuki and Koji Tamakoshi and Kenji Wakai and Masayo Kojima and Kotaro Ozasa and Yoshiyuki Watanabe and Miyuki Kawado and Shuji Hashimoto and Sadao Suzuki and Sinkan Tokudome and Hideaki Toyoshima and Norihiko Hayakawa and Kazuo Kato and Makoto Watanabe and Yoshiji Ohta and Morito Maruta and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Harou Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kukori and Kazuo Tajima",
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Ito, Y, Suzuki, K, Tamakoshi, K, Wakai, K, Kojima, M, Ozasa, K, Watanabe, Y, Kawado, M, Hashimoto, S, Suzuki, S, Tokudome, S, Toyoshima, H, Hayakawa, N, Kato, K, Watanabe, M, Ohta, Y, Maruta, M, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kukori, T & Tajima, K 2005, 'Coloretal cancer and serum C-reactive protein levels: A case-control study nested in the JACC study', Journal of epidemiology, vol. 15, no. SUPPL. 2. https://doi.org/10.2188/jea.15.S185

Coloretal cancer and serum C-reactive protein levels : A case-control study nested in the JACC study. / Ito, Yoshinori; Suzuki, Koji; Tamakoshi, Koji; Wakai, Kenji; Kojima, Masayo; Ozasa, Kotaro; Watanabe, Yoshiyuki; Kawado, Miyuki; Hashimoto, Shuji; Suzuki, Sadao; Tokudome, Sinkan; Toyoshima, Hideaki; Hayakawa, Norihiko; Kato, Kazuo; Watanabe, Makoto; Ohta, Yoshiji; Maruta, Morito; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Harou; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kukori, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. SUPPL. 2, 14.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coloretal cancer and serum C-reactive protein levels

T2 - A case-control study nested in the JACC study

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Kojima, Masayo

AU - Ozasa, Kotaro

AU - Watanabe, Yoshiyuki

AU - Kawado, Miyuki

AU - Hashimoto, Shuji

AU - Suzuki, Sadao

AU - Tokudome, Sinkan

AU - Toyoshima, Hideaki

AU - Hayakawa, Norihiko

AU - Kato, Kazuo

AU - Watanabe, Makoto

AU - Ohta, Yoshiji

AU - Maruta, Morito

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Harou

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kukori, Toshio

AU - Tajima, Kazuo

PY - 2005/10/14

Y1 - 2005/10/14

N2 - Background: Recently, it has been hypothesized that inflammation increases the risk of colorectal cancer. We investigated whether serum levels of C-reactive protein (CRP), a biomarker of inflammation, are associated with colorectal cancer, using serum samples collected in the Japan Collaborative Cohort Study (JACC Study). Methods: We conducted a nested case-control study in the JACC Study, investigating the relationship between the risk for colorectal cancer and serum levels of CRP determined by a high-sensitivity CRP enzyme immunoassay. The subjects recruited were 141 patients with colorectal cancer (63 males and 78 females) and 327 controls with no history of cancer (148 males and 179 females). Each case of colorectal cancer was matched for sex, age and participating institution to 2 or 3 controls. We used t-test to analyze mean differences in CRP levels between colorectal cancer cases and controls. Odds ratios (ORs) and their 95% confidence intervals (Cls) were calculated using a conditional logistic regression model after adjusting for the potential confounding factors. Results: Serum CRP levels were not clearly associated with the risk of colorectal cancer. The OR of the highest serum CRP levels was 1.18 (95% Cl: 0.68-2.06) for colorectal cancer and 1.42 (95% Cl: 0.73-2.74) for colon cancer, compared to subjects with lowest serum levels. The OR for incidence of colorectal cancer showed a similar trend, but the difference was not significant. Thus, high serum CRP levels did not appear to increase the risk of colorectal cancer. Conclusions: The present results suggest that high serum CRP levels are not associated with the risk of colorectal cancer in the JACC Study.

AB - Background: Recently, it has been hypothesized that inflammation increases the risk of colorectal cancer. We investigated whether serum levels of C-reactive protein (CRP), a biomarker of inflammation, are associated with colorectal cancer, using serum samples collected in the Japan Collaborative Cohort Study (JACC Study). Methods: We conducted a nested case-control study in the JACC Study, investigating the relationship between the risk for colorectal cancer and serum levels of CRP determined by a high-sensitivity CRP enzyme immunoassay. The subjects recruited were 141 patients with colorectal cancer (63 males and 78 females) and 327 controls with no history of cancer (148 males and 179 females). Each case of colorectal cancer was matched for sex, age and participating institution to 2 or 3 controls. We used t-test to analyze mean differences in CRP levels between colorectal cancer cases and controls. Odds ratios (ORs) and their 95% confidence intervals (Cls) were calculated using a conditional logistic regression model after adjusting for the potential confounding factors. Results: Serum CRP levels were not clearly associated with the risk of colorectal cancer. The OR of the highest serum CRP levels was 1.18 (95% Cl: 0.68-2.06) for colorectal cancer and 1.42 (95% Cl: 0.73-2.74) for colon cancer, compared to subjects with lowest serum levels. The OR for incidence of colorectal cancer showed a similar trend, but the difference was not significant. Thus, high serum CRP levels did not appear to increase the risk of colorectal cancer. Conclusions: The present results suggest that high serum CRP levels are not associated with the risk of colorectal cancer in the JACC Study.

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U2 - 10.2188/jea.15.S185

DO - 10.2188/jea.15.S185

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JO - Journal of Epidemiology

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