Combination Chemotherapy with S-1 and Docetaxel in Advanced Gastric Cancer patient with Peritoneal Dissemination and Malignant Ascites

Background; Combined chemotherapy with S-1 and docetaxel was implemented in patient with advanced or recurrent gastric cancer associated with peritoneal dissemination and malignant ascites. Methods; S-1 was administered orally at 80 mg/m² for 14 consecutive days and docetaxel was administered at 40 mg/m² on day 1, followed by a 1-week rest, as one course, and the treatment was repeated until progression or severe toxicity. Results; Three out of the five patients showed response to the treatment. The three patients with response had diffuse-type tumor according to the Lauren's classification. The median number of treatment courses was 4. The median survival time was 315 days, the median time to treatment failure was 225 days, and the 1-year survival rate was 20%. Conclusions; These results suggest that combined therapy with S-1 and docetaxel is a promising treatment for advanced or recurrent gastric cancer with malignant ascites and peritoneal dissemination.