TY - JOUR
T1 - Combined analysis of the pre- and postoperative neutrophil–lymphocyte ratio predicts the outcomes of patients with gastric cancer
AU - Miyatani, Kozo
AU - Saito, Hiroaki
AU - Kono, Yusuke
AU - Murakami, Yuki
AU - Kuroda, Hirohiko
AU - Matsunaga, Tomoyuki
AU - Fukumoto, Yoji
AU - Osaki, Tomohiro
AU - Ashida, Keigo
AU - Fujiwara, Yoshiyuki
N1 - Publisher Copyright:
© 2017, Springer Japan KK.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose: The neutrophil–lymphocyte ratio (NLR) is a biochemical marker of the systemic inflammatory response and has been associated with prognosis for various types of cancer. This retrospective study investigates the relationship between the pre- and postoperative NLR and the prognosis of gastric cancer patients. Methods: The subjects were 280 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma. Results: The preoperative NLR was significantly correlated with tumor size, tumor depth, lymphatic invasion, venous invasion, and disease stage. In contrast, there was no correlation between the postoperative NLR and the various clinicopathological variables. Prognosis was significantly worse for patients with a high preoperative NLR than for those with a low preoperative NLR. Prognosis was also significantly worse for patients with a high postoperative NLR than for those with a low postoperative NLR. Furthermore, the prognosis was worse for gastric cancer patients whose pre- and postoperative NLRs were both high. Multivariate analysis indicated that a high pre- and postoperative NLR was an independent prognostic indicator. Conclusions: The combination of pre- and postoperative NLRs appears to be useful for predicting the prognosis of gastric cancer patients.
AB - Purpose: The neutrophil–lymphocyte ratio (NLR) is a biochemical marker of the systemic inflammatory response and has been associated with prognosis for various types of cancer. This retrospective study investigates the relationship between the pre- and postoperative NLR and the prognosis of gastric cancer patients. Methods: The subjects were 280 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma. Results: The preoperative NLR was significantly correlated with tumor size, tumor depth, lymphatic invasion, venous invasion, and disease stage. In contrast, there was no correlation between the postoperative NLR and the various clinicopathological variables. Prognosis was significantly worse for patients with a high preoperative NLR than for those with a low preoperative NLR. Prognosis was also significantly worse for patients with a high postoperative NLR than for those with a low postoperative NLR. Furthermore, the prognosis was worse for gastric cancer patients whose pre- and postoperative NLRs were both high. Multivariate analysis indicated that a high pre- and postoperative NLR was an independent prognostic indicator. Conclusions: The combination of pre- and postoperative NLRs appears to be useful for predicting the prognosis of gastric cancer patients.
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U2 - 10.1007/s00595-017-1587-6
DO - 10.1007/s00595-017-1587-6
M3 - Article
C2 - 28916967
AN - SCOPUS:85029501709
SN - 0941-1291
VL - 48
SP - 300
EP - 307
JO - Surgery Today
JF - Surgery Today
IS - 3
ER -