TY - JOUR
T1 - Combined analysis of the preoperative and postoperative prognostic nutritional index offers a precise predictor of the prognosis of patients with gastric cancer
AU - Murakami, Yuki
AU - Saito, Hiroaki
AU - Kono, Yusuke
AU - Shishido, Yuji
AU - Kuroda, Hirohiko
AU - Matsunaga, Tomoyuki
AU - Fukumoto, Yoji
AU - Osaki, Tomohiro
AU - Ashida, Keigo
AU - Fujiwara, Yoshiyuki
N1 - Publisher Copyright:
© 2017, Springer Japan KK.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Purpose: The prognostic nutritional index (PNI) is considered useful for predicting the prognosis of patients with gastric cancer (GC). This retrospective study investigated the relationship between both the pre- and postoperative PNI and the prognosis of GC patients. Methods: The subjects of this study were 254 patients who underwent curative surgery for histopathologically diagnosed GC. Results: Patients were divided according to their pre- and postoperative PNI as follows: preoperative PNI of ≥ 52 (pre-PNIHigh), preoperative PNI of < 52 (pre-PNILow), postoperative PNI of ≥ 49 (post-PNIHigh), and postoperative PNI of < 49 (pre-PNILow). Both pre- and postoperative PNI were significantly associated with GC prognosis. Patients were then divided as follows: group A, patients with pre-PNIHigh and post-PNIHigh; group B, patients with either pre-PNIHigh and post-PNILow or pre-PNILow and post-PNIHigh; and group C, patients with pre-PNILow and post-PNILow. The 5-year survival rates were 100.0, 83.0, and 67.1% for groups A, B, and C, respectively. Multivariate analysis indicated that the combination of pre- and postoperative PNI was an independent prognostic indicator. Conclusions: Combined analysis of the pre- and postoperative PNI offers accurate information about the prognosis of patients with GC.
AB - Purpose: The prognostic nutritional index (PNI) is considered useful for predicting the prognosis of patients with gastric cancer (GC). This retrospective study investigated the relationship between both the pre- and postoperative PNI and the prognosis of GC patients. Methods: The subjects of this study were 254 patients who underwent curative surgery for histopathologically diagnosed GC. Results: Patients were divided according to their pre- and postoperative PNI as follows: preoperative PNI of ≥ 52 (pre-PNIHigh), preoperative PNI of < 52 (pre-PNILow), postoperative PNI of ≥ 49 (post-PNIHigh), and postoperative PNI of < 49 (pre-PNILow). Both pre- and postoperative PNI were significantly associated with GC prognosis. Patients were then divided as follows: group A, patients with pre-PNIHigh and post-PNIHigh; group B, patients with either pre-PNIHigh and post-PNILow or pre-PNILow and post-PNIHigh; and group C, patients with pre-PNILow and post-PNILow. The 5-year survival rates were 100.0, 83.0, and 67.1% for groups A, B, and C, respectively. Multivariate analysis indicated that the combination of pre- and postoperative PNI was an independent prognostic indicator. Conclusions: Combined analysis of the pre- and postoperative PNI offers accurate information about the prognosis of patients with GC.
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U2 - 10.1007/s00595-017-1599-2
DO - 10.1007/s00595-017-1599-2
M3 - Article
C2 - 29027629
AN - SCOPUS:85031413125
SN - 0941-1291
VL - 48
SP - 395
EP - 403
JO - Surgery Today
JF - Surgery Today
IS - 4
ER -
