Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case

Shigeru Miyagawa; Goro Matsumiya; Toshihiro Funatsu; Masao Yoshitatsu; Naozumi Sekiya; Shinya Fukui; Takaya Hoashi; Masatsugu Hori; Hideki Yoshikawa; Yuzuru Kanakura; Jun Ishikawa; Katsuyuki Aozasa; Naomasa Kawaguchi; Nariaki Matsuura; Akira Myoui; Akifumi Matsuyama; Sachiko Ezoe; Hidehiro Iida; Hikaru Matsuda; Yoshiki Sawa

doi:10.1007/s00595-008-3803-x

Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case

Shigeru Miyagawa, Goro Matsumiya, Toshihiro Funatsu, Masao Yoshitatsu, Naozumi Sekiya, Shinya Fukui, Takaya Hoashi, Masatsugu Hori, Hideki Yoshikawa, Yuzuru Kanakura, Jun Ishikawa, Katsuyuki Aozasa, Naomasa Kawaguchi, Nariaki Matsuura, Akira Myoui, Akifumi Matsuyama, Sachiko Ezoe, Hidehiro Iida, Hikaru Matsuda, Yoshiki Sawa

Regenerative Medicine

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.

Original language	English
Pages (from-to)	133-136
Number of pages	4
Journal	Surgery Today
Volume	39
Issue number	2
DOIs	https://doi.org/10.1007/s00595-008-3803-x
Publication status	Published - 02-2009

All Science Journal Classification (ASJC) codes

Surgery

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Miyagawa, S., Matsumiya, G., Funatsu, T., Yoshitatsu, M., Sekiya, N., Fukui, S., Hoashi, T., Hori, M., Yoshikawa, H., Kanakura, Y., Ishikawa, J., Aozasa, K., Kawaguchi, N., Matsuura, N., Myoui, A., Matsuyama, A., Ezoe, S., Iida, H., Matsuda, H., & Sawa, Y. (2009). Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case. Surgery Today, 39(2), 133-136. https://doi.org/10.1007/s00595-008-3803-x

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abstract = "Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.",

author = "Shigeru Miyagawa and Goro Matsumiya and Toshihiro Funatsu and Masao Yoshitatsu and Naozumi Sekiya and Shinya Fukui and Takaya Hoashi and Masatsugu Hori and Hideki Yoshikawa and Yuzuru Kanakura and Jun Ishikawa and Katsuyuki Aozasa and Naomasa Kawaguchi and Nariaki Matsuura and Akira Myoui and Akifumi Matsuyama and Sachiko Ezoe and Hidehiro Iida and Hikaru Matsuda and Yoshiki Sawa",

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Miyagawa, S, Matsumiya, G, Funatsu, T, Yoshitatsu, M, Sekiya, N, Fukui, S, Hoashi, T, Hori, M, Yoshikawa, H, Kanakura, Y, Ishikawa, J, Aozasa, K, Kawaguchi, N, Matsuura, N, Myoui, A, Matsuyama, A, Ezoe, S, Iida, H, Matsuda, H & Sawa, Y 2009, 'Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case', Surgery Today, vol. 39, no. 2, pp. 133-136. https://doi.org/10.1007/s00595-008-3803-x

Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case. / Miyagawa, Shigeru; Matsumiya, Goro; Funatsu, Toshihiro et al.
In: Surgery Today, Vol. 39, No. 2, 02.2009, p. 133-136.

Research output: Contribution to journal › Article › peer-review

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T1 - Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation

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AU - Miyagawa, Shigeru

AU - Matsumiya, Goro

AU - Funatsu, Toshihiro

AU - Yoshitatsu, Masao

AU - Sekiya, Naozumi

AU - Fukui, Shinya

AU - Hoashi, Takaya

AU - Hori, Masatsugu

AU - Yoshikawa, Hideki

AU - Kanakura, Yuzuru

AU - Ishikawa, Jun

AU - Aozasa, Katsuyuki

AU - Kawaguchi, Naomasa

AU - Matsuura, Nariaki

AU - Myoui, Akira

AU - Matsuyama, Akifumi

AU - Ezoe, Sachiko

AU - Iida, Hidehiro

AU - Matsuda, Hikaru

AU - Sawa, Yoshiki

PY - 2009/2

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Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case

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