Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case

Shigeru Miyagawa, Goro Matsumiya, Toshihiro Funatsu, Masao Yoshitatsu, Naozumi Sekiya, Shinya Fukui, Takaya Hoashi, Masatsugu Hori, Hideki Yoshikawa, Yuzuru Kanakura, Jun Ishikawa, Katsuyuki Aozasa, Naomasa Kawaguchi, Nariaki Matsuura, Akira Myoui, Akifumi Matsuyama, Sachiko Ezoe, Hidehiro Iida, Hikaru Matsuda, Yoshiki Sawa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalSurgery Today
Volume39
Issue number2
DOIs
Publication statusPublished - 01-02-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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    Miyagawa, S., Matsumiya, G., Funatsu, T., Yoshitatsu, M., Sekiya, N., Fukui, S., Hoashi, T., Hori, M., Yoshikawa, H., Kanakura, Y., Ishikawa, J., Aozasa, K., Kawaguchi, N., Matsuura, N., Myoui, A., Matsuyama, A., Ezoe, S., Iida, H., Matsuda, H., & Sawa, Y. (2009). Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case. Surgery Today, 39(2), 133-136. https://doi.org/10.1007/s00595-008-3803-x