Combined effects of polaprezinc and nizatidine on gastric duodenal lesions in rats

Combined effects of polaprezinc and nizatidine on several experimental models of gastric and duodenal lesions, were investigated in ras. Polaprezinc (1 10 mg/kg), but not nizatidine (10 mg/kg), prevented the development of acidified ethanol induced gastric lesions. Effect of polaprezinc in combination with nizatidine were more potent than those of polaprezinc alone. Polaprezinc (1 30 mg/kg) and nizatidine (3 mg/kg) prevented the development of gastric and duodenal lesions induced by water immersion stress, indomethacin and mepirizole. The inhibitory effect of polaprezinc was increased by the combined use with nizatidine. In acetic acid induced gastric ulcers, the combined administration of polaprezinc (0.3 3 mg/kg) and nizatidine (10 mg/kg) potentiated the ulcer healing in comparison with each drug alone. The inhibitory effect of nizatidine (3 mg/kg) in the basal acid secretion was not influenced by the combine treatment of polaprezinc (3 30 mg/kg). Nizatidine (10 mg/kg) significantly increased gastric emptying, whereas polaprezinc had no such effect. The enhancement of gastric emptying by nizatidine was not influenced by the combine treatment of polaprezinc. The zinc contents of the ulcer region in acetic acid ulcer were significantly increased by the combined use with nizatidine in comparison with each drug alone. These results suggest that the combination of polaprezinc and a H₂ receptor antagonist such as nizatidine may be more effective for the treatment of gastric lesions in clinical therapy.