Combined effects of polaprezine and omeprazole on gastric duodenal lesions in rats

Combined effects of polaprezine and omeprazole on several experimental models of gastric and duodenal lesions, were investigated in rats. Polaprezine (1-10 mg/kg), but not omeprazole (10 mg/kg), prevented the development of acidified ethanol induced gastric lesions. Effect of polaprezine in combination with omeprazole were more potent than those of polaprezinc alone. Polaprezinc (1-30 mg/kg) and omeprazole (1-10 mg/kg) prevented the development of gastric and duodenal lesions induced by water immersion stress, indomethacin and mepirizole. The inhibitory effect of polaprezinc was increased by the combined use with omeprazole. In acetic acid induced gastric ulcers, the combined administration of polaprezinc (0.3-3 mg/kg) and omeprazole (10 mg/kg) potentiated the ulcer healing in comparison with each drug alone. The inhibitory effect of omeprazole (10 mg/kg) in the basal acid secretion was not influenced by the combine treatment of polaprezinc (3-30 mg/kg). The zinc contents of the ulcer region after administration of polaprezinc (3 mg/kg) were significantly increased by the combined use with omeprazole (10 mg/kg) in comparison with each drag alone. These results suggest that the combination of polaprezinc and a proton pump inhibitor such as omeprazole, may be more effective for the treatment of gastric lesions in clinical therapy.