Combined therapy with radiofrequency thermal ablation and intra-arterial infusion chemotherapy for hepatic metastases from colorectal cancer

Osamu Kainuma, Takehide Asano, Hiromichi Aoyama, Wataru Takayama, Toshio Nakagohri, Takashi Kenmochi, Masayuki Hasegawa, Yoshiharu Tokoro, Shinichi Sasagawa, Takenori Ochiai

Research output: Contribution to journalArticle

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Abstract

BACKGROUMD/AIMS: In this preliminary study, we investigated the efficacy of combined radiofrequency thermal ablation therapy (RFA) with hepatic arterial infusion chemotherapy (HAI) in the treatment of multiple liver metastases from colorectal cancer. METHODOLOGY: Nine patients with bilobular multiple metastases was treated. The number of nodules was 6.0 ± 3.9 (range: 2-13), and the size was 2.1 ± 1.0 cm (range: 0.5-4.8 cm) in diameter. RFA was performed using a RF generator operating at 460 kHz with a 15-gauge, 4-prong custom RF needle. Treatment temperature was kept at 90-110°C for 5 min. 5-Fluorouracil (5-FU) was administered by weekly 750-1250 mg/body/5 h as the regimen of HAI. RESULTS: During a 15.2-month follow-up period, 6 of 9 patients survived more than 1 year. Three of the 6 survived more than 2 years. Serum CEA level in 5 patients dropped from 24.5 ± 9.5 ng/ml to 10.3 ± 5.5 ng/ml. Local recurrence was observed in 5 patients and new lesions in 4. Extrahepatic recurrence was observed in 5 patients. There were no serious complications but one HAI-related cerebral thrombosis. CONCLUSIONS: Combined RFA with HAI would be effective and safe. This modality provides a new option for the treatment of multiple liver metastases from colorectal cancer.

Original languageEnglish
Pages (from-to)1071-1077
Number of pages7
JournalHepato-gastroenterology
Volume46
Issue number26
Publication statusPublished - 25-05-1999

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Intra Arterial Infusions
Colorectal Neoplasms
Hot Temperature
Neoplasm Metastasis
Drug Therapy
Liver
Therapeutics
Recurrence
Intracranial Thrombosis
Fluorouracil
Needles
Temperature
Serum

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kainuma, Osamu ; Asano, Takehide ; Aoyama, Hiromichi ; Takayama, Wataru ; Nakagohri, Toshio ; Kenmochi, Takashi ; Hasegawa, Masayuki ; Tokoro, Yoshiharu ; Sasagawa, Shinichi ; Ochiai, Takenori. / Combined therapy with radiofrequency thermal ablation and intra-arterial infusion chemotherapy for hepatic metastases from colorectal cancer. In: Hepato-gastroenterology. 1999 ; Vol. 46, No. 26. pp. 1071-1077.
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Kainuma, O, Asano, T, Aoyama, H, Takayama, W, Nakagohri, T, Kenmochi, T, Hasegawa, M, Tokoro, Y, Sasagawa, S & Ochiai, T 1999, 'Combined therapy with radiofrequency thermal ablation and intra-arterial infusion chemotherapy for hepatic metastases from colorectal cancer', Hepato-gastroenterology, vol. 46, no. 26, pp. 1071-1077.

Combined therapy with radiofrequency thermal ablation and intra-arterial infusion chemotherapy for hepatic metastases from colorectal cancer. / Kainuma, Osamu; Asano, Takehide; Aoyama, Hiromichi; Takayama, Wataru; Nakagohri, Toshio; Kenmochi, Takashi; Hasegawa, Masayuki; Tokoro, Yoshiharu; Sasagawa, Shinichi; Ochiai, Takenori.

In: Hepato-gastroenterology, Vol. 46, No. 26, 25.05.1999, p. 1071-1077.

Research output: Contribution to journalArticle

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T1 - Combined therapy with radiofrequency thermal ablation and intra-arterial infusion chemotherapy for hepatic metastases from colorectal cancer

AU - Kainuma, Osamu

AU - Asano, Takehide

AU - Aoyama, Hiromichi

AU - Takayama, Wataru

AU - Nakagohri, Toshio

AU - Kenmochi, Takashi

AU - Hasegawa, Masayuki

AU - Tokoro, Yoshiharu

AU - Sasagawa, Shinichi

AU - Ochiai, Takenori

PY - 1999/5/25

Y1 - 1999/5/25

N2 - BACKGROUMD/AIMS: In this preliminary study, we investigated the efficacy of combined radiofrequency thermal ablation therapy (RFA) with hepatic arterial infusion chemotherapy (HAI) in the treatment of multiple liver metastases from colorectal cancer. METHODOLOGY: Nine patients with bilobular multiple metastases was treated. The number of nodules was 6.0 ± 3.9 (range: 2-13), and the size was 2.1 ± 1.0 cm (range: 0.5-4.8 cm) in diameter. RFA was performed using a RF generator operating at 460 kHz with a 15-gauge, 4-prong custom RF needle. Treatment temperature was kept at 90-110°C for 5 min. 5-Fluorouracil (5-FU) was administered by weekly 750-1250 mg/body/5 h as the regimen of HAI. RESULTS: During a 15.2-month follow-up period, 6 of 9 patients survived more than 1 year. Three of the 6 survived more than 2 years. Serum CEA level in 5 patients dropped from 24.5 ± 9.5 ng/ml to 10.3 ± 5.5 ng/ml. Local recurrence was observed in 5 patients and new lesions in 4. Extrahepatic recurrence was observed in 5 patients. There were no serious complications but one HAI-related cerebral thrombosis. CONCLUSIONS: Combined RFA with HAI would be effective and safe. This modality provides a new option for the treatment of multiple liver metastases from colorectal cancer.

AB - BACKGROUMD/AIMS: In this preliminary study, we investigated the efficacy of combined radiofrequency thermal ablation therapy (RFA) with hepatic arterial infusion chemotherapy (HAI) in the treatment of multiple liver metastases from colorectal cancer. METHODOLOGY: Nine patients with bilobular multiple metastases was treated. The number of nodules was 6.0 ± 3.9 (range: 2-13), and the size was 2.1 ± 1.0 cm (range: 0.5-4.8 cm) in diameter. RFA was performed using a RF generator operating at 460 kHz with a 15-gauge, 4-prong custom RF needle. Treatment temperature was kept at 90-110°C for 5 min. 5-Fluorouracil (5-FU) was administered by weekly 750-1250 mg/body/5 h as the regimen of HAI. RESULTS: During a 15.2-month follow-up period, 6 of 9 patients survived more than 1 year. Three of the 6 survived more than 2 years. Serum CEA level in 5 patients dropped from 24.5 ± 9.5 ng/ml to 10.3 ± 5.5 ng/ml. Local recurrence was observed in 5 patients and new lesions in 4. Extrahepatic recurrence was observed in 5 patients. There were no serious complications but one HAI-related cerebral thrombosis. CONCLUSIONS: Combined RFA with HAI would be effective and safe. This modality provides a new option for the treatment of multiple liver metastases from colorectal cancer.

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