Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

Shusuke Akamatsu; Ryo Takata; Christopher A. Haiman; Atsushi Takahashi; Takahiro Inoue; Michiaki Kubo; Mutsuo Furihata; Naoyuki Kamatani; Johji Inazawa; Gary K. Chen; Loïc Le Marchand; Laurence N. Kolonel; Takahiko Katoh; Yuko Yamano; Minoru Yamakado; Hiroyuki Takahashi; Hiroki Yamada; Shin Egawa; Tomoaki Fujioka; Brian E. Henderson; Tomonori Habuchi; Osamu Ogawa; Yusuke Nakamura; Hidewaki Nakagawa

doi:10.1038/ng.1104

Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

Shusuke Akamatsu, Ryo Takata, Christopher A. Haiman, Atsushi Takahashi, Takahiro Inoue, Michiaki Kubo, Mutsuo Furihata, Naoyuki Kamatani, Johji Inazawa, Gary K. Chen, Loïc Le Marchand, Laurence N. Kolonel, Takahiko Katoh, Yuko Yamano, Minoru Yamakado, Hiroyuki Takahashi, Hiroki Yamada, Shin Egawa, Tomoaki Fujioka, Brian E. HendersonTomonori Habuchi, Osamu Ogawa, Yusuke Nakamura, Hidewaki Nakagawa

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Abstract

We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10 ^-4) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10 ^-10; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10 ^-8) and 3p11.2 (rs2055109; P = 3.94 x 10 ^-8). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10 ^-7). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.

Original language	English
Pages (from-to)	426-429
Number of pages	4
Journal	Nature Genetics
Volume	44
Issue number	4
DOIs	https://doi.org/10.1038/ng.1104
Publication status	Published - 04-2012

All Science Journal Classification (ASJC) codes

Genetics

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Akamatsu, S., Takata, R., Haiman, C. A., Takahashi, A., Inoue, T., Kubo, M., Furihata, M., Kamatani, N., Inazawa, J., Chen, G. K., Le Marchand, L., Kolonel, L. N., Katoh, T., Yamano, Y., Yamakado, M., Takahashi, H., Yamada, H., Egawa, S., Fujioka, T., ... Nakagawa, H. (2012). Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. Nature Genetics, 44(4), 426-429. https://doi.org/10.1038/ng.1104

Akamatsu, Shusuke ; Takata, Ryo ; Haiman, Christopher A. ; Takahashi, Atsushi ; Inoue, Takahiro ; Kubo, Michiaki ; Furihata, Mutsuo ; Kamatani, Naoyuki ; Inazawa, Johji ; Chen, Gary K. ; Le Marchand, Loïc ; Kolonel, Laurence N. ; Katoh, Takahiko ; Yamano, Yuko ; Yamakado, Minoru ; Takahashi, Hiroyuki ; Yamada, Hiroki ; Egawa, Shin ; Fujioka, Tomoaki ; Henderson, Brian E. ; Habuchi, Tomonori ; Ogawa, Osamu ; Nakamura, Yusuke ; Nakagawa, Hidewaki. / Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. In: Nature Genetics. 2012 ; Vol. 44, No. 4. pp. 426-429.

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title = "Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese",

abstract = "We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10 -4) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10 -10; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10 -8) and 3p11.2 (rs2055109; P = 3.94 x 10 -8). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10 -7). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.",

author = "Shusuke Akamatsu and Ryo Takata and Haiman, {Christopher A.} and Atsushi Takahashi and Takahiro Inoue and Michiaki Kubo and Mutsuo Furihata and Naoyuki Kamatani and Johji Inazawa and Chen, {Gary K.} and {Le Marchand}, Lo{\"i}c and Kolonel, {Laurence N.} and Takahiko Katoh and Yuko Yamano and Minoru Yamakado and Hiroyuki Takahashi and Hiroki Yamada and Shin Egawa and Tomoaki Fujioka and Henderson, {Brian E.} and Tomonori Habuchi and Osamu Ogawa and Yusuke Nakamura and Hidewaki Nakagawa",

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doi = "10.1038/ng.1104",

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Akamatsu, S, Takata, R, Haiman, CA, Takahashi, A, Inoue, T, Kubo, M, Furihata, M, Kamatani, N, Inazawa, J, Chen, GK, Le Marchand, L, Kolonel, LN, Katoh, T, Yamano, Y, Yamakado, M, Takahashi, H, Yamada, H, Egawa, S, Fujioka, T, Henderson, BE, Habuchi, T, Ogawa, O, Nakamura, Y & Nakagawa, H 2012, 'Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese', Nature Genetics, vol. 44, no. 4, pp. 426-429. https://doi.org/10.1038/ng.1104

Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. / Akamatsu, Shusuke; Takata, Ryo; Haiman, Christopher A.; Takahashi, Atsushi; Inoue, Takahiro; Kubo, Michiaki; Furihata, Mutsuo; Kamatani, Naoyuki; Inazawa, Johji; Chen, Gary K.; Le Marchand, Loïc; Kolonel, Laurence N.; Katoh, Takahiko; Yamano, Yuko; Yamakado, Minoru; Takahashi, Hiroyuki; Yamada, Hiroki; Egawa, Shin; Fujioka, Tomoaki; Henderson, Brian E.; Habuchi, Tomonori; Ogawa, Osamu; Nakamura, Yusuke; Nakagawa, Hidewaki.

In: Nature Genetics, Vol. 44, No. 4, 04.2012, p. 426-429.

Research output: Contribution to journal › Article › peer-review

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AU - Akamatsu, Shusuke

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AU - Takahashi, Atsushi

AU - Inoue, Takahiro

AU - Kubo, Michiaki

AU - Furihata, Mutsuo

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AU - Yamano, Yuko

AU - Yamakado, Minoru

AU - Takahashi, Hiroyuki

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AU - Egawa, Shin

AU - Fujioka, Tomoaki

AU - Henderson, Brian E.

AU - Habuchi, Tomonori

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