Abstract
We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10 -4 ) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10 -10 ; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10 -8 ) and 3p11.2 (rs2055109; P = 3.94 x 10 -8 ). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10 -7 ). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
| Original language | English |
|---|---|
| Pages (from-to) | 426-429 |
| Number of pages | 4 |
| Journal | Nature Genetics |
| Volume | 44 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-04-2012 |
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All Science Journal Classification (ASJC) codes
- Genetics
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Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. / Akamatsu, Shusuke; Takata, Ryo; Haiman, Christopher A.; Takahashi, Atsushi; Inoue, Takahiro; Kubo, Michiaki; Furihata, Mutsuo; Kamatani, Naoyuki; Inazawa, Johji; Chen, Gary K.; Le Marchand, Loïc; Kolonel, Laurence N.; Katoh, Takahiko; Yamano, Yuko; Yamakado, Minoru; Takahashi, Hiroyuki; Yamada, Hiroki; Egawa, Shin; Fujioka, Tomoaki; Henderson, Brian E.; Habuchi, Tomonori; Ogawa, Osamu; Nakamura, Yusuke; Nakagawa, Hidewaki.
In: Nature Genetics, Vol. 44, No. 4, 01.04.2012, p. 426-429.Research output: Contribution to journal › Article
TY - JOUR
T1 - Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese
AU - Akamatsu, Shusuke
AU - Takata, Ryo
AU - Haiman, Christopher A.
AU - Takahashi, Atsushi
AU - Inoue, Takahiro
AU - Kubo, Michiaki
AU - Furihata, Mutsuo
AU - Kamatani, Naoyuki
AU - Inazawa, Johji
AU - Chen, Gary K.
AU - Le Marchand, Loïc
AU - Kolonel, Laurence N.
AU - Katoh, Takahiko
AU - Yamano, Yuko
AU - Yamakado, Minoru
AU - Takahashi, Hiroyuki
AU - Yamada, Hiroki
AU - Egawa, Shin
AU - Fujioka, Tomoaki
AU - Henderson, Brian E.
AU - Habuchi, Tomonori
AU - Ogawa, Osamu
AU - Nakamura, Yusuke
AU - Nakagawa, Hidewaki
PY - 2012/4/1
Y1 - 2012/4/1
N2 - We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10 -4 ) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10 -10 ; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10 -8 ) and 3p11.2 (rs2055109; P = 3.94 x 10 -8 ). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10 -7 ). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
AB - We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10 -4 ) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10 -10 ; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10 -8 ) and 3p11.2 (rs2055109; P = 3.94 x 10 -8 ). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10 -7 ). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
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U2 - 10.1038/ng.1104
DO - 10.1038/ng.1104
M3 - Article
VL - 44
SP - 426
EP - 429
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -