TY - JOUR
T1 - Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations
AU - Okada, Yukinori
AU - Kubo, Michiaki
AU - Ohmiya, Hiroko
AU - Takahashi, Atsushi
AU - Kumasaka, Natsuhiko
AU - Hosono, Naoya
AU - Maeda, Shiro
AU - Wen, Wanqing
AU - Dorajoo, Rajkumar
AU - Go, Min Jin
AU - Zheng, Wei
AU - Kato, Norihiro
AU - Wu, Jer Yuarn
AU - Lu, Qi
AU - Tsunoda, Tatsuhiko
AU - Yamamoto, Kazuhiko
AU - Nakamura, Yusuke
AU - Kamatani, Naoyuki
AU - Tanaka, Toshihiro
N1 - Funding Information:
We thank K. Tobe and M. Iwata at the First Department of Internal Medicine, Faculty of Medicine, Toyama University, H. Hirose at Health Center, Keio University School of Medicine and all the staff of the Laboratory for Endocrinology, Metabolism and Statistical Analysis at CGM, RIKEN for their assistance. This study was supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2012/3
Y1 - 2012/3
N2 - Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass indexĝ€"associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 - 10 g11) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 - 10 g9), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 - 10 g8). We subsequently performed gene-gene interaction analyses and identified an interaction (P = 2.0 - 10 g8) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.
AB - Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass indexĝ€"associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 - 10 g11) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 - 10 g9), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 - 10 g8). We subsequently performed gene-gene interaction analyses and identified an interaction (P = 2.0 - 10 g8) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.
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U2 - 10.1038/ng.1086
DO - 10.1038/ng.1086
M3 - Article
C2 - 22344221
AN - SCOPUS:84862822438
SN - 1061-4036
VL - 44
SP - 302
EP - 306
JO - Nature Genetics
JF - Nature Genetics
IS - 3
ER -
