Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

Yukinori Okada, Michiaki Kubo, Hiroko Ohmiya, Atsushi Takahashi, Natsuhiko Kumasaka, Naoya Hosono, Shiro Maeda, Wanqing Wen, Rajkumar Dorajoo, Min Jin Go, Wei Zheng, Norihiro Kato, Jer Yuarn Wu, Qi Lu, Tatsuhiko Tsunoda, Kazuhiko Yamamoto, Yusuke Nakamura, Naoyuki Kamatani, Toshihiro Tanaka

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass indexĝ€"associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 - 10 g11) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 - 10 g9), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 - 10 g8). We subsequently performed gene-gene interaction analyses and identified an interaction (P = 2.0 - 10 g8) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.

Original languageEnglish
Pages (from-to)302-306
Number of pages5
JournalNature Genetics
Volume44
Issue number3
DOIs
Publication statusPublished - 01-03-2012

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Body Mass Index
Obesity
Population
Genetic Loci
Genome-Wide Association Study
Brain-Derived Neurotrophic Factor
Genes
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Okada, Y., Kubo, M., Ohmiya, H., Takahashi, A., Kumasaka, N., Hosono, N., ... Tanaka, T. (2012). Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nature Genetics, 44(3), 302-306. https://doi.org/10.1038/ng.1086
Okada, Yukinori ; Kubo, Michiaki ; Ohmiya, Hiroko ; Takahashi, Atsushi ; Kumasaka, Natsuhiko ; Hosono, Naoya ; Maeda, Shiro ; Wen, Wanqing ; Dorajoo, Rajkumar ; Go, Min Jin ; Zheng, Wei ; Kato, Norihiro ; Wu, Jer Yuarn ; Lu, Qi ; Tsunoda, Tatsuhiko ; Yamamoto, Kazuhiko ; Nakamura, Yusuke ; Kamatani, Naoyuki ; Tanaka, Toshihiro. / Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. In: Nature Genetics. 2012 ; Vol. 44, No. 3. pp. 302-306.
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Okada, Y, Kubo, M, Ohmiya, H, Takahashi, A, Kumasaka, N, Hosono, N, Maeda, S, Wen, W, Dorajoo, R, Go, MJ, Zheng, W, Kato, N, Wu, JY, Lu, Q, Tsunoda, T, Yamamoto, K, Nakamura, Y, Kamatani, N & Tanaka, T 2012, 'Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations', Nature Genetics, vol. 44, no. 3, pp. 302-306. https://doi.org/10.1038/ng.1086

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. / Okada, Yukinori; Kubo, Michiaki; Ohmiya, Hiroko; Takahashi, Atsushi; Kumasaka, Natsuhiko; Hosono, Naoya; Maeda, Shiro; Wen, Wanqing; Dorajoo, Rajkumar; Go, Min Jin; Zheng, Wei; Kato, Norihiro; Wu, Jer Yuarn; Lu, Qi; Tsunoda, Tatsuhiko; Yamamoto, Kazuhiko; Nakamura, Yusuke; Kamatani, Naoyuki; Tanaka, Toshihiro.

In: Nature Genetics, Vol. 44, No. 3, 01.03.2012, p. 302-306.

Research output: Contribution to journalArticle

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AU - Okada, Yukinori

AU - Kubo, Michiaki

AU - Ohmiya, Hiroko

AU - Takahashi, Atsushi

AU - Kumasaka, Natsuhiko

AU - Hosono, Naoya

AU - Maeda, Shiro

AU - Wen, Wanqing

AU - Dorajoo, Rajkumar

AU - Go, Min Jin

AU - Zheng, Wei

AU - Kato, Norihiro

AU - Wu, Jer Yuarn

AU - Lu, Qi

AU - Tsunoda, Tatsuhiko

AU - Yamamoto, Kazuhiko

AU - Nakamura, Yusuke

AU - Kamatani, Naoyuki

AU - Tanaka, Toshihiro

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N2 - Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass indexĝ€"associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 - 10 g11) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 - 10 g9), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 - 10 g8). We subsequently performed gene-gene interaction analyses and identified an interaction (P = 2.0 - 10 g8) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.

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