Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in Schizophrenic patients

Takayoshi Koide, Masahiro Banno, Branko Aleksic, Saori Yamashita, Tsutomu Kikuchi, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Itaru Kushima, Yukako Nakamura, Takashi Okada, Masashi Ikeda, Kazutaka Ohi, Yuka Yasuda, Ryota Hashimoto, Toshiya Inada, Hiroshi Ujike, Tetsuya Iidaka, Michio Suzuki, Masatoshi Takeda & 2 others Nakao Iwata, Norio Ozaki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (~1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. In this case-control study, we examined the relationship of single nucleotide polymorphism (SNP) variations in MAGI2 and risk for schizophrenia in a large Japanese sample and explored the potential relationships between variations in MAGI2 and aspects of human cognitive function related to glutamate activity. Based on the result of first schizophrenia genome-wide association study in a Japanese population (JGWAS), we selected four independent SNPs and performed an association study using a large independent Japanese sample set (cases 1624, controls 1621). Wisconsin Card Sorting Test (WCST) was used to evaluate executive function in 114 cases and 91 controls. We found suggestive evidence for genetic association of common SNPs within MAGI2 locus and schizophrenia in Japanese population. Furthermore in terms of association between MAGI2 and cognitive performance, we observed that genotype effect of rs2190665 on WCST score was significant (p = 0.034) and rs4729938 trended toward significance (p = 0.08). In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients.

Original languageEnglish
Article numbere36836
JournalPloS one
Volume7
Issue number5
DOIs
Publication statusPublished - 23-05-2012

Fingerprint

Schizophrenia
Genes
Sorting
Single Nucleotide Polymorphism
cognition
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Neurotransmitter Receptor
genes
Glutamate Receptors
N-Methylaspartate
Chromosomes
Polymorphism
sorting
signs and symptoms (animals and humans)
Glutamic Acid
Nucleotides
Population
behavior disorders
Genome-Wide Association Study
Executive Function

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Koide, T., Banno, M., Aleksic, B., Yamashita, S., Kikuchi, T., Kohmura, K., ... Ozaki, N. (2012). Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in Schizophrenic patients. PloS one, 7(5), [e36836]. https://doi.org/10.1371/journal.pone.0036836
Koide, Takayoshi ; Banno, Masahiro ; Aleksic, Branko ; Yamashita, Saori ; Kikuchi, Tsutomu ; Kohmura, Kunihiro ; Adachi, Yasunori ; Kawano, Naoko ; Kushima, Itaru ; Nakamura, Yukako ; Okada, Takashi ; Ikeda, Masashi ; Ohi, Kazutaka ; Yasuda, Yuka ; Hashimoto, Ryota ; Inada, Toshiya ; Ujike, Hiroshi ; Iidaka, Tetsuya ; Suzuki, Michio ; Takeda, Masatoshi ; Iwata, Nakao ; Ozaki, Norio. / Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in Schizophrenic patients. In: PloS one. 2012 ; Vol. 7, No. 5.
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Koide, T, Banno, M, Aleksic, B, Yamashita, S, Kikuchi, T, Kohmura, K, Adachi, Y, Kawano, N, Kushima, I, Nakamura, Y, Okada, T, Ikeda, M, Ohi, K, Yasuda, Y, Hashimoto, R, Inada, T, Ujike, H, Iidaka, T, Suzuki, M, Takeda, M, Iwata, N & Ozaki, N 2012, 'Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in Schizophrenic patients', PloS one, vol. 7, no. 5, e36836. https://doi.org/10.1371/journal.pone.0036836

Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in Schizophrenic patients. / Koide, Takayoshi; Banno, Masahiro; Aleksic, Branko; Yamashita, Saori; Kikuchi, Tsutomu; Kohmura, Kunihiro; Adachi, Yasunori; Kawano, Naoko; Kushima, Itaru; Nakamura, Yukako; Okada, Takashi; Ikeda, Masashi; Ohi, Kazutaka; Yasuda, Yuka; Hashimoto, Ryota; Inada, Toshiya; Ujike, Hiroshi; Iidaka, Tetsuya; Suzuki, Michio; Takeda, Masatoshi; Iwata, Nakao; Ozaki, Norio.

In: PloS one, Vol. 7, No. 5, e36836, 23.05.2012.

Research output: Contribution to journalArticle

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T1 - Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in Schizophrenic patients

AU - Koide, Takayoshi

AU - Banno, Masahiro

AU - Aleksic, Branko

AU - Yamashita, Saori

AU - Kikuchi, Tsutomu

AU - Kohmura, Kunihiro

AU - Adachi, Yasunori

AU - Kawano, Naoko

AU - Kushima, Itaru

AU - Nakamura, Yukako

AU - Okada, Takashi

AU - Ikeda, Masashi

AU - Ohi, Kazutaka

AU - Yasuda, Yuka

AU - Hashimoto, Ryota

AU - Inada, Toshiya

AU - Ujike, Hiroshi

AU - Iidaka, Tetsuya

AU - Suzuki, Michio

AU - Takeda, Masatoshi

AU - Iwata, Nakao

AU - Ozaki, Norio

PY - 2012/5/23

Y1 - 2012/5/23

N2 - Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (~1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. In this case-control study, we examined the relationship of single nucleotide polymorphism (SNP) variations in MAGI2 and risk for schizophrenia in a large Japanese sample and explored the potential relationships between variations in MAGI2 and aspects of human cognitive function related to glutamate activity. Based on the result of first schizophrenia genome-wide association study in a Japanese population (JGWAS), we selected four independent SNPs and performed an association study using a large independent Japanese sample set (cases 1624, controls 1621). Wisconsin Card Sorting Test (WCST) was used to evaluate executive function in 114 cases and 91 controls. We found suggestive evidence for genetic association of common SNPs within MAGI2 locus and schizophrenia in Japanese population. Furthermore in terms of association between MAGI2 and cognitive performance, we observed that genotype effect of rs2190665 on WCST score was significant (p = 0.034) and rs4729938 trended toward significance (p = 0.08). In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients.

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