TY - JOUR
T1 - Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in Schizophrenic patients
AU - Koide, Takayoshi
AU - Banno, Masahiro
AU - Aleksic, Branko
AU - Yamashita, Saori
AU - Kikuchi, Tsutomu
AU - Kohmura, Kunihiro
AU - Adachi, Yasunori
AU - Kawano, Naoko
AU - Kushima, Itaru
AU - Nakamura, Yukako
AU - Okada, Takashi
AU - Ikeda, Masashi
AU - Ohi, Kazutaka
AU - Yasuda, Yuka
AU - Hashimoto, Ryota
AU - Inada, Toshiya
AU - Ujike, Hiroshi
AU - Iidaka, Tetsuya
AU - Suzuki, Michio
AU - Takeda, Masatoshi
AU - Iwata, Nakao
AU - Ozaki, Norio
PY - 2012/5/23
Y1 - 2012/5/23
N2 - Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (~1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. In this case-control study, we examined the relationship of single nucleotide polymorphism (SNP) variations in MAGI2 and risk for schizophrenia in a large Japanese sample and explored the potential relationships between variations in MAGI2 and aspects of human cognitive function related to glutamate activity. Based on the result of first schizophrenia genome-wide association study in a Japanese population (JGWAS), we selected four independent SNPs and performed an association study using a large independent Japanese sample set (cases 1624, controls 1621). Wisconsin Card Sorting Test (WCST) was used to evaluate executive function in 114 cases and 91 controls. We found suggestive evidence for genetic association of common SNPs within MAGI2 locus and schizophrenia in Japanese population. Furthermore in terms of association between MAGI2 and cognitive performance, we observed that genotype effect of rs2190665 on WCST score was significant (p = 0.034) and rs4729938 trended toward significance (p = 0.08). In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients.
AB - Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (~1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. In this case-control study, we examined the relationship of single nucleotide polymorphism (SNP) variations in MAGI2 and risk for schizophrenia in a large Japanese sample and explored the potential relationships between variations in MAGI2 and aspects of human cognitive function related to glutamate activity. Based on the result of first schizophrenia genome-wide association study in a Japanese population (JGWAS), we selected four independent SNPs and performed an association study using a large independent Japanese sample set (cases 1624, controls 1621). Wisconsin Card Sorting Test (WCST) was used to evaluate executive function in 114 cases and 91 controls. We found suggestive evidence for genetic association of common SNPs within MAGI2 locus and schizophrenia in Japanese population. Furthermore in terms of association between MAGI2 and cognitive performance, we observed that genotype effect of rs2190665 on WCST score was significant (p = 0.034) and rs4729938 trended toward significance (p = 0.08). In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients.
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U2 - 10.1371/journal.pone.0036836
DO - 10.1371/journal.pone.0036836
M3 - Article
C2 - 22649501
AN - SCOPUS:84861411147
SN - 1932-6203
VL - 7
JO - PloS one
JF - PloS one
IS - 5
M1 - e36836
ER -