Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

Vinod Kumar, Keitaro Matsuo, Atsushi Takahashi, Naoya Hosono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Sun Young Kong, Hidewaki Nakagawa, Ri Cui, Chizu Tanikawa, Masao Seto, Yasuo Morishima, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.

Original languageEnglish
Pages (from-to)436-439
Number of pages4
JournalJournal of Human Genetics
Volume56
Issue number6
DOIs
Publication statusPublished - 01-06-2011

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Lymphoma, Large B-Cell, Diffuse
Genome-Wide Association Study
Odds Ratio
Genetic Translocation
Disease Susceptibility
Genetic Predisposition to Disease
Introns
Genes
Single Nucleotide Polymorphism
Lymphoma
B-Lymphocytes
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Kumar, V., Matsuo, K., Takahashi, A., Hosono, N., Tsunoda, T., Kamatani, N., ... Matsuda, K. (2011). Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Journal of Human Genetics, 56(6), 436-439. https://doi.org/10.1038/jhg.2011.35
Kumar, Vinod ; Matsuo, Keitaro ; Takahashi, Atsushi ; Hosono, Naoya ; Tsunoda, Tatsuhiko ; Kamatani, Naoyuki ; Kong, Sun Young ; Nakagawa, Hidewaki ; Cui, Ri ; Tanikawa, Chizu ; Seto, Masao ; Morishima, Yasuo ; Kubo, Michiaki ; Nakamura, Yusuke ; Matsuda, Koichi. / Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. In: Journal of Human Genetics. 2011 ; Vol. 56, No. 6. pp. 436-439.
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Kumar, V, Matsuo, K, Takahashi, A, Hosono, N, Tsunoda, T, Kamatani, N, Kong, SY, Nakagawa, H, Cui, R, Tanikawa, C, Seto, M, Morishima, Y, Kubo, M, Nakamura, Y & Matsuda, K 2011, 'Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility', Journal of Human Genetics, vol. 56, no. 6, pp. 436-439. https://doi.org/10.1038/jhg.2011.35

Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. / Kumar, Vinod; Matsuo, Keitaro; Takahashi, Atsushi; Hosono, Naoya; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Kong, Sun Young; Nakagawa, Hidewaki; Cui, Ri; Tanikawa, Chizu; Seto, Masao; Morishima, Yasuo; Kubo, Michiaki; Nakamura, Yusuke; Matsuda, Koichi.

In: Journal of Human Genetics, Vol. 56, No. 6, 01.06.2011, p. 436-439.

Research output: Contribution to journalArticle

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AU - Kamatani, Naoyuki

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AU - Nakagawa, Hidewaki

AU - Cui, Ri

AU - Tanikawa, Chizu

AU - Seto, Masao

AU - Morishima, Yasuo

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AU - Nakamura, Yusuke

AU - Matsuda, Koichi

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Kumar V, Matsuo K, Takahashi A, Hosono N, Tsunoda T, Kamatani N et al. Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Journal of Human Genetics. 2011 Jun 1;56(6):436-439. https://doi.org/10.1038/jhg.2011.35