Comparative studies of asparagine-linked sugar chains of immunoglobulin G from eleven mammalian species

Jiharu Hamako, Taei Matsui, Yasuhiro Ozeki, Tsuguo Mizuochi, Koiti Titani

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

1. 1. Asparagine-linked sugar chains released by hydrazinolysis from IgGs of porcine, equine, bovine, goat, ovine, canine, rabbit, guinea-pig and rat were comparatively analyzed by microsequencing and lectin affinity chromatography. 2. 2. Sugar chains of all IgGs basically consisted of biantennary complex-type oligosaccharides containing 0-2 sialic acid residue(s). More than 70% of the oligosaccharides were neutral, except for guinea-pig IgG, and fucosylated trimannosyl core structures were dominant except for rabbit IgG. Bisecting N-acetylglucosamine residue was absent in porcine and equine IgGs. 3. 3. A large quantity of galactose-less oligosaccharides were present in IgGs of porcine, equine, canine and rat.

Original languageEnglish
Pages (from-to)949-954
Number of pages6
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume106
Issue number4
DOIs
Publication statusPublished - 12-1993

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Comparative studies of asparagine-linked sugar chains of immunoglobulin G from eleven mammalian species'. Together they form a unique fingerprint.

Cite this