Comparison between 1-year outcomes of aflibercept with and without photodynamic therapy for polypoidal choroidal vasculopathy: Retrospective observation study

Kei Takayama, Hiroki Kaneko, Keiko Kataoka, Kyoko Hattori, Eimei Ra, Taichi Tsunekawa, Hiroshi Fukukita, Fuminori Haga, Yasuki Ito, Hiroko Terasaki

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Polypoidal choroidal vasculopathy (PCV) is characterized by polyp-like choroidal neovascularization and a branching vascular network. Intravitreal aflibercept injection (IAI) or photodynamic therapy (PDT) is used for treatment. We retrospectively compared the 1-year outcomes of IAI monotherapy and its combination with initial PDT for PCV. Twelve eyes with nave PCV received three IAIs and a single PDT after the first IAI and as needed injection (combination group); 11 eyes with nave PCV received three IAIs and as needed injections (IAI group). Significant improvements in visual acuity after 2 months and in CRT after 1 month were maintained at 12 months in both groups (both P < 0.05); groups did not differ significantly at any time point. CCT significantly reduced after 3 and 12 months in the combination group (both P < 0.05) but not in the IAI group. A mean of 3.7 ± 0.9 and 5.6 ± 2.0 injections was administered to the combination and IAI groups, respectively (P = 0.013). Within a 1-year period, combination therapy was found to yield similar visual acuity and retinal structure improvements and maintenance as IAI monotherapy while requiring fewer IAIs.

Original languageEnglish
Article numbere0176100
JournalPloS one
Volume12
Issue number5
DOIs
Publication statusPublished - 05-2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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