Comparison between chemoradiotherapy and bioradiotherapy after induction chemotherapy in head and neck cancer

Chiaki Suzuki, Tomomasa Hayashi, Morimasa Kitamura, Ichiro Tateya, Yo Kishimoto, Seiji Ishikawa, Haruo Inokuchi, Michio Yoshimura, Motoo Nomura, Shigeru Hirano

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of this study was to evaluate the completion rate and the toxicity of chemoradiotherapy with CDDP (CDDP-RT)and bioradiotherapy with cetuximab (BRT) following induction chemotherapy (ICT) in locally advanced head and neck squamous cell carcinoma (LA-SCCHN). Materials and Methods: This retrospective study includes 22 patients with ICT followed by CDDP-RT and 18 patients with cetuximab-RT at our hospital from April 2009 to December 2014. We compared CDDP-RT and cetuximab-RT in terms of the ratio of adverse events (CTCAE ver. 4), nutrition support, and treatment compliance. Results: Treatment compliance was better in cetuximab-RT than CDDP-RT. The adverse events of neutro-penia, anemia and creatinine increase were almost equal between CDDP-RT and cetuximab-RT. Acute mucosi-tis, dermatitis and dysphagia were more frequent in cetuximab-RT. Dysphagia tended to be more prolonged in cetuximab-RT than CDDP-RT. Conclusion: In terms of compliance, cetuximab-RT seems to be more suitable after induction chemotherapy. However, cetuximab-RT causes more severe mucositis and dysphagia, which warrants good support.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalJapanese Journal of Head and Neck Cancer
Volume42
Issue number1
DOIs
Publication statusPublished - 01-01-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Oncology

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