TY - JOUR
T1 - Comparison of capability of dynamic O 2-enhanced MRI and quantitative thin-section MDCT to assess COPD in smokers
AU - Ohno, Yoshiharu
AU - Koyama, Hisanobu
AU - Yoshikawa, Takeshi
AU - Matsumoto, Keiko
AU - Aoyama, Nobukazu
AU - Onishi, Yumiko
AU - Takenaka, Daisuke
AU - Matsumoto, Sumiaki
AU - Nishimura, Yoshihiro
AU - Sugimura, Kazuro
N1 - Funding Information:
This work was partly supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (JSTS.KAKEN; No. 18591346), the Knowledge Cluster Initiative of the Ministry of Education, Culture, Sports, Science and Technology, Japan, the Smoking Research Foundation and Philips Electronics Japan.
PY - 2012/5
Y1 - 2012/5
N2 - Purpose: The purpose of this study was to directly and prospectively compare the capability of dynamic O 2-enhanced MRI and quantitatively assessed thin-section MDCT to assess smokers' COPD in a large prospective cohort. Materials and methods: The GOLD criteria for smokers were used to classify 187 smokers into four clinical stage groups as follows: smokers without COPD (n = 56) and with mild (n = 54), moderate (n = 52) and severe or very severe COPD (n = 24). All smokers underwent dynamic O 2-enhanced MRI, MDCT and pulmonary function tests. Mean relative enhancement ratio and mean wash-in time on MRI and CT-based functional lung volume (CT-based FLV) as well as the ratio of airway wall area to total airway area on MDCT were computationally calculated. Then, all indexes were significantly correlated with functional parameters. To determine the efficacy of all indexes for clinical stage classification, the indexes for the four clinical groups were statistically compared by using Tukey's honestly significant difference multiple comparison test. Results: All indexes had significant correlations with functional parameters (p < 0.0001). All indexes except CT-based FLV in all groups had significant differences each other (p < 0.05). Conclusions: Dynamic O 2-enhanced MRI for assessment of COPD in smokers is potentially as efficacious as quantitatively assessed thin-section MDCT.
AB - Purpose: The purpose of this study was to directly and prospectively compare the capability of dynamic O 2-enhanced MRI and quantitatively assessed thin-section MDCT to assess smokers' COPD in a large prospective cohort. Materials and methods: The GOLD criteria for smokers were used to classify 187 smokers into four clinical stage groups as follows: smokers without COPD (n = 56) and with mild (n = 54), moderate (n = 52) and severe or very severe COPD (n = 24). All smokers underwent dynamic O 2-enhanced MRI, MDCT and pulmonary function tests. Mean relative enhancement ratio and mean wash-in time on MRI and CT-based functional lung volume (CT-based FLV) as well as the ratio of airway wall area to total airway area on MDCT were computationally calculated. Then, all indexes were significantly correlated with functional parameters. To determine the efficacy of all indexes for clinical stage classification, the indexes for the four clinical groups were statistically compared by using Tukey's honestly significant difference multiple comparison test. Results: All indexes had significant correlations with functional parameters (p < 0.0001). All indexes except CT-based FLV in all groups had significant differences each other (p < 0.05). Conclusions: Dynamic O 2-enhanced MRI for assessment of COPD in smokers is potentially as efficacious as quantitatively assessed thin-section MDCT.
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U2 - 10.1016/j.ejrad.2011.02.004
DO - 10.1016/j.ejrad.2011.02.004
M3 - Article
C2 - 21392914
AN - SCOPUS:84859968078
SN - 0720-048X
VL - 81
SP - 1068
EP - 1075
JO - European journal of radiology
JF - European journal of radiology
IS - 5
ER -