Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men

Kunihiro Matsushita, Hiroshi Yatsuya, Koji Tamakoshi, Keiko Wada, Rei Otsuka, Seiko Takefuji, Kaichiro Sugiura, Takahisa Kondo, Toyoaki Murohara, Hideaki Toyoshima

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Background - Anti-inflammatory and proinflammatory molecules purportedly play an important role in developing metabolic syndrome (MetS). However, little is known as to the relative importance of these molecules in the association with MetS. Methods and Results - We studied 624 middle-aged Japanese men without medical history of cardiovascular disease or cancer and investigated the associations of circulating tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and adiponectin with MetS. We used the respective definitions proposed by the National Cholesterol Education Program Adult Treatment Panel III (ATP-III), the International Diabetes Federation, and the Japanese Society of Internal Medicine. Decreased serum adiponectin was observed in those with any of the ATP-III-MetS components, whereas this was not the case with increased TNF-α, IL-6, or CRP. Adiponectin and CRP levels linearly deteriorated with an increasing number of ATP-III-MetS components (trend P<0.001, respectively). Significantly higher CRP and lower adiponectin levels were observed in those who met any MetS criteria, whereas increased TNF-α was observed in only those with ATP-III-MetS. Finally, odds ratios (ORs) for MetS prevalence of a 1-SD increase/decrease in log-transformed 4 markers were calculated with multivariate logistic regression analyses. Consequently, decreased adiponectin was associated most strongly with ATP-III-MetS (adiponectin: OR, 1.90 [95% CI, 1.44 to 2.51]; P<0.001; CRP: OR, 1.33 [95% CI, 1.01 to 1.74]; P=0.03; TNF-α: OR, 1.25 [95% CI, 0.94 to 1.67]; P=0.12; and IL-6: OR, 0.87 [95% CI, 0.63 to 1.19]; P=0.37). This result was not altered by using the other 2 criteria. Conclusions - The present results raise the possibility that decreased serum adiponectin might be fundamentally involved in the development of MetS.

Original languageEnglish
Pages (from-to)871-876
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume26
Issue number4
DOIs
Publication statusPublished - 01-04-2006
Externally publishedYes

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Adiponectin
C-Reactive Protein
Odds Ratio
Interleukin-6
Tumor Necrosis Factor-alpha
Lymphotoxin-beta
Therapeutics
Internal Medicine
Serum
Anti-Inflammatory Agents
Cardiovascular Diseases
Logistic Models
Cholesterol
Regression Analysis
Education

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Matsushita, Kunihiro ; Yatsuya, Hiroshi ; Tamakoshi, Koji ; Wada, Keiko ; Otsuka, Rei ; Takefuji, Seiko ; Sugiura, Kaichiro ; Kondo, Takahisa ; Murohara, Toyoaki ; Toyoshima, Hideaki. / Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2006 ; Vol. 26, No. 4. pp. 871-876.
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Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. / Matsushita, Kunihiro; Yatsuya, Hiroshi; Tamakoshi, Koji; Wada, Keiko; Otsuka, Rei; Takefuji, Seiko; Sugiura, Kaichiro; Kondo, Takahisa; Murohara, Toyoaki; Toyoshima, Hideaki.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 26, No. 4, 01.04.2006, p. 871-876.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men

AU - Matsushita, Kunihiro

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Wada, Keiko

AU - Otsuka, Rei

AU - Takefuji, Seiko

AU - Sugiura, Kaichiro

AU - Kondo, Takahisa

AU - Murohara, Toyoaki

AU - Toyoshima, Hideaki

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Background - Anti-inflammatory and proinflammatory molecules purportedly play an important role in developing metabolic syndrome (MetS). However, little is known as to the relative importance of these molecules in the association with MetS. Methods and Results - We studied 624 middle-aged Japanese men without medical history of cardiovascular disease or cancer and investigated the associations of circulating tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and adiponectin with MetS. We used the respective definitions proposed by the National Cholesterol Education Program Adult Treatment Panel III (ATP-III), the International Diabetes Federation, and the Japanese Society of Internal Medicine. Decreased serum adiponectin was observed in those with any of the ATP-III-MetS components, whereas this was not the case with increased TNF-α, IL-6, or CRP. Adiponectin and CRP levels linearly deteriorated with an increasing number of ATP-III-MetS components (trend P<0.001, respectively). Significantly higher CRP and lower adiponectin levels were observed in those who met any MetS criteria, whereas increased TNF-α was observed in only those with ATP-III-MetS. Finally, odds ratios (ORs) for MetS prevalence of a 1-SD increase/decrease in log-transformed 4 markers were calculated with multivariate logistic regression analyses. Consequently, decreased adiponectin was associated most strongly with ATP-III-MetS (adiponectin: OR, 1.90 [95% CI, 1.44 to 2.51]; P<0.001; CRP: OR, 1.33 [95% CI, 1.01 to 1.74]; P=0.03; TNF-α: OR, 1.25 [95% CI, 0.94 to 1.67]; P=0.12; and IL-6: OR, 0.87 [95% CI, 0.63 to 1.19]; P=0.37). This result was not altered by using the other 2 criteria. Conclusions - The present results raise the possibility that decreased serum adiponectin might be fundamentally involved in the development of MetS.

AB - Background - Anti-inflammatory and proinflammatory molecules purportedly play an important role in developing metabolic syndrome (MetS). However, little is known as to the relative importance of these molecules in the association with MetS. Methods and Results - We studied 624 middle-aged Japanese men without medical history of cardiovascular disease or cancer and investigated the associations of circulating tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and adiponectin with MetS. We used the respective definitions proposed by the National Cholesterol Education Program Adult Treatment Panel III (ATP-III), the International Diabetes Federation, and the Japanese Society of Internal Medicine. Decreased serum adiponectin was observed in those with any of the ATP-III-MetS components, whereas this was not the case with increased TNF-α, IL-6, or CRP. Adiponectin and CRP levels linearly deteriorated with an increasing number of ATP-III-MetS components (trend P<0.001, respectively). Significantly higher CRP and lower adiponectin levels were observed in those who met any MetS criteria, whereas increased TNF-α was observed in only those with ATP-III-MetS. Finally, odds ratios (ORs) for MetS prevalence of a 1-SD increase/decrease in log-transformed 4 markers were calculated with multivariate logistic regression analyses. Consequently, decreased adiponectin was associated most strongly with ATP-III-MetS (adiponectin: OR, 1.90 [95% CI, 1.44 to 2.51]; P<0.001; CRP: OR, 1.33 [95% CI, 1.01 to 1.74]; P=0.03; TNF-α: OR, 1.25 [95% CI, 0.94 to 1.67]; P=0.12; and IL-6: OR, 0.87 [95% CI, 0.63 to 1.19]; P=0.37). This result was not altered by using the other 2 criteria. Conclusions - The present results raise the possibility that decreased serum adiponectin might be fundamentally involved in the development of MetS.

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