Comparison of Free Light Chain Removal by Four Blood Purification Methods

Kyoko Kanayama, Atsushi Ohashi, Midori Hasegawa, Fumiko Kondo, Yoshihiro Yamamoto, Mayu Sasaki, Hiroki Hayashi, Masao Kato, Ryoko Hattori, Hiroshi Yamashita, Jiro Arai, Junichi Ishii, Nobuhiko Emi, Yukio Yuzawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Renal failure is a frequent complication in patients with multiple myeloma. Immunoglobulin free light chains (FLCs) form casts in the distal tubules, resulting in renal obstruction, and are also directly toxic to proximal renal tubules. Removal of FLCs contributes to renal recovery. High cut-off (HCO) membrane Theralite2100, protein leaking dialyzer PES210Dα, plasma separator Evacure1A20 and β 2 microglobulin adsorption column LixelleS-35 were compared in their FLC removal rate. Dialysis using Theralite2100 or Evacure1A20, diafiltration using PES210Dα and adsorption using LixelleS-35 were performed in an in vitro circuit. The highest removal rate was obtained by Theralite2100 dialysis among the four blood purification methods. Albumin loss was also the greatest in Theralite2100 dialysis. The removal content of FLCs per 1g albumin loss was better in PES210Dα diafiltration. The removal rate of FLCs by Evacure EC1A-20 dialysis was the third highest. Adsorption of FLCs by the β 2 microglobulin adsorption column Lixelle S-35 was confirmed. In conclusion, Theralite2100 dialysis was the best in removal of FLCs. PES210Dα diafiltration can remove FLCs with smaller loss of albumin.

Original languageEnglish
Pages (from-to)394-399
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Issue number4
Publication statusPublished - 08-2011

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology


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