Comparison of myoglobin clearance in three types of blood purification modalities

Shinya Suzuki, Kazuhiro Moriyama, Yoshitaka Hara, Takuya Hinoue, Yu Kato, Daisuke Hasegawa, Naohide Kuriyama, Tomoyuki Nakamura, Satoshi Komatsu, Chizuru Yamashita, Hidefumi Komura, Osamu Nishida

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Myoglobin, which can cause acute kidney injury, has a relatively high molecular weight and is poorly cleared by diffusion. We compared and examined myoglobin clearance by changing the blood purification membrane and modality in patients with a myoglobin blood concentration ≥ 1000 ng/ml. We retrospectively analyzed three patient groups based on the following three types of continuous hemofiltration (CHF): AN69ST membrane, polymethylmethacrylate (PMMA) membrane, and high-flow hemodiafiltration (HDF) with increased dialysate flow rate using the PMMA membrane. There was no significant difference in clearance in CHF between AN69ST and PMMA membranes. However, the high-flow HDF group showed the highest myoglobin clearance (p = 0.003). In the PMMA membrane, changing the treatment modality to high-flow HDF increased clearance above the theoretical value, possibly due to internal filtration. To remove myoglobin by kidney replacement therapy from patients with hypermyoglobinemia, a modality such as high-flow HDF would be desirable.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume25
Issue number4
DOIs
Publication statusPublished - 08-2021

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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