Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis: A Nationwide Survey

Mayu Yamamoto, Saori Nagashima, Yoshiyuki Yamada, Takatsugu Murakoshi, Yasuyuki Shimoyama, Sakuma Takahashi, Hideyuki Seki, Takashi Kobayashi, Yuichi Hara, Hiromi Tadaki, Norihisa Ishimura, Shunji Ishihara, Yoshikazu Kinoshita, Hideaki Morita, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto, Ichiro Nomura

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: Eosinophilic esophagitis (EoE) has increased rapidly and has been well characterized. However, no nationwide survey has been conducted regarding non–esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs), and they remain poorly understood. Objective: To compare the clinical features and natural histories of non-EoE EGIDs and EoE by using the same questionnaire, for all ages. Methods: We conducted a nationwide hospital-based survey of patients who visited hospitals from January 2013 through December 2017. We randomly selected 10,000 hospitals that perform endoscopy. We analyzed the demographics, symptoms, gastrointestinal histology, treatments, and natural histories of EoE and non-EoE EGIDs. Results: A total of 2906 hospitals responded to the questionnaire. We identified 1542 patients and obtained detailed data for 786 patients, consisting of 39% EoE and 61% non-EoE EGIDs. The clinical characteristics were analyzed for patients who met the “definite” criteria that excluded comorbidities. Non-EoE EGIDs showed no gender difference, whereas EoE was male-predominant. Tissue eosinophilia was often seen in the small intestine (62%) and stomach (49%). The frequency of hypoproteinemia was high (27%) in childhood. Children also had more serious symptoms and complications than adults: restriction of daily life activity (P =.009), failure to grow/weight loss (P =.008), and surgery (P =.01). For both diseases, the most common natural history was the continuous type: 66% (95% confidence interval [CI]: 58-74) in EoE and 64% (95% CI: 55-72) in non-EoE EGIDs. Conclusions: The percentage of persistent patients with non-EoE EGIDs was almost the same as those with EoE. Complications were more frequent in children than in adults.

Original languageEnglish
Pages (from-to)3339-3349.e8
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume9
Issue number9
DOIs
Publication statusPublished - 09-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Fingerprint

Dive into the research topics of 'Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis: A Nationwide Survey'. Together they form a unique fingerprint.

Cite this