TY - JOUR
T1 - Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis
T2 - A Nationwide Survey
AU - Yamamoto, Mayu
AU - Nagashima, Saori
AU - Yamada, Yoshiyuki
AU - Murakoshi, Takatsugu
AU - Shimoyama, Yasuyuki
AU - Takahashi, Sakuma
AU - Seki, Hideyuki
AU - Kobayashi, Takashi
AU - Hara, Yuichi
AU - Tadaki, Hiromi
AU - Ishimura, Norihisa
AU - Ishihara, Shunji
AU - Kinoshita, Yoshikazu
AU - Morita, Hideaki
AU - Ohya, Yukihiro
AU - Saito, Hirohisa
AU - Matsumoto, Kenji
AU - Nomura, Ichiro
N1 - Publisher Copyright:
© 2021 American Academy of Allergy, Asthma & Immunology
PY - 2021/9
Y1 - 2021/9
N2 - Background: Eosinophilic esophagitis (EoE) has increased rapidly and has been well characterized. However, no nationwide survey has been conducted regarding non–esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs), and they remain poorly understood. Objective: To compare the clinical features and natural histories of non-EoE EGIDs and EoE by using the same questionnaire, for all ages. Methods: We conducted a nationwide hospital-based survey of patients who visited hospitals from January 2013 through December 2017. We randomly selected 10,000 hospitals that perform endoscopy. We analyzed the demographics, symptoms, gastrointestinal histology, treatments, and natural histories of EoE and non-EoE EGIDs. Results: A total of 2906 hospitals responded to the questionnaire. We identified 1542 patients and obtained detailed data for 786 patients, consisting of 39% EoE and 61% non-EoE EGIDs. The clinical characteristics were analyzed for patients who met the “definite” criteria that excluded comorbidities. Non-EoE EGIDs showed no gender difference, whereas EoE was male-predominant. Tissue eosinophilia was often seen in the small intestine (62%) and stomach (49%). The frequency of hypoproteinemia was high (27%) in childhood. Children also had more serious symptoms and complications than adults: restriction of daily life activity (P =.009), failure to grow/weight loss (P =.008), and surgery (P =.01). For both diseases, the most common natural history was the continuous type: 66% (95% confidence interval [CI]: 58-74) in EoE and 64% (95% CI: 55-72) in non-EoE EGIDs. Conclusions: The percentage of persistent patients with non-EoE EGIDs was almost the same as those with EoE. Complications were more frequent in children than in adults.
AB - Background: Eosinophilic esophagitis (EoE) has increased rapidly and has been well characterized. However, no nationwide survey has been conducted regarding non–esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs), and they remain poorly understood. Objective: To compare the clinical features and natural histories of non-EoE EGIDs and EoE by using the same questionnaire, for all ages. Methods: We conducted a nationwide hospital-based survey of patients who visited hospitals from January 2013 through December 2017. We randomly selected 10,000 hospitals that perform endoscopy. We analyzed the demographics, symptoms, gastrointestinal histology, treatments, and natural histories of EoE and non-EoE EGIDs. Results: A total of 2906 hospitals responded to the questionnaire. We identified 1542 patients and obtained detailed data for 786 patients, consisting of 39% EoE and 61% non-EoE EGIDs. The clinical characteristics were analyzed for patients who met the “definite” criteria that excluded comorbidities. Non-EoE EGIDs showed no gender difference, whereas EoE was male-predominant. Tissue eosinophilia was often seen in the small intestine (62%) and stomach (49%). The frequency of hypoproteinemia was high (27%) in childhood. Children also had more serious symptoms and complications than adults: restriction of daily life activity (P =.009), failure to grow/weight loss (P =.008), and surgery (P =.01). For both diseases, the most common natural history was the continuous type: 66% (95% confidence interval [CI]: 58-74) in EoE and 64% (95% CI: 55-72) in non-EoE EGIDs. Conclusions: The percentage of persistent patients with non-EoE EGIDs was almost the same as those with EoE. Complications were more frequent in children than in adults.
KW - Eosinophilic colitis (EC)
KW - Eosinophilic esophagitis (EoE)
KW - Eosinophilic gastritis (EG)
KW - Eosinophilic gastroenteritis (EGE)
KW - Eosinophilic gastrointestinal disorders
KW - Nationwide survey
KW - Natural history
KW - Non–esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs)
KW - Treatment
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U2 - 10.1016/j.jaip.2021.06.026
DO - 10.1016/j.jaip.2021.06.026
M3 - Article
C2 - 34214704
AN - SCOPUS:85111263279
SN - 2213-2198
VL - 9
SP - 3339-3349.e8
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 9
ER -