Comparison of specific immunities to varicella-zoster virus following post-exposure prophylaxis of varicella by oral acyclovir observed in a family

Yoshizo Asano, Sadao Suga, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An otherwise healthy 3-year-old girl developed severe varicella complicated by aseptic meningitis and received intravenous acyclovir (ACV) therapy. Her two siblings who were susceptible to varicella-zoster virus (VZV) and closely exposed to VZV in the family received oral ACV (45 or 54 mg/kg per day in four divided doses for 7 days) starting 8 days after onset of the index case for post-exposure prophylaxis of varicella. They showed only five or seven papules over the body without fever 12 days after onset of the index case, while they had one-third or half the level of antibody titer and equal sized skin reactions to VZV antigen of the index case 2.5 months later.

Original languageEnglish
Pages (from-to)692-694
Number of pages3
JournalPediatrics International
Volume38
Issue number6
DOIs
Publication statusPublished - 01-01-1996

Fingerprint

Post-Exposure Prophylaxis
Human Herpesvirus 3
Acyclovir
Chickenpox
Immunity
Aseptic Meningitis
Siblings
Fever
Antigens
Skin
Antibodies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{aa58ef0a4d6a4f1ba195c1b7312f4924,
title = "Comparison of specific immunities to varicella-zoster virus following post-exposure prophylaxis of varicella by oral acyclovir observed in a family",
abstract = "An otherwise healthy 3-year-old girl developed severe varicella complicated by aseptic meningitis and received intravenous acyclovir (ACV) therapy. Her two siblings who were susceptible to varicella-zoster virus (VZV) and closely exposed to VZV in the family received oral ACV (45 or 54 mg/kg per day in four divided doses for 7 days) starting 8 days after onset of the index case for post-exposure prophylaxis of varicella. They showed only five or seven papules over the body without fever 12 days after onset of the index case, while they had one-third or half the level of antibody titer and equal sized skin reactions to VZV antigen of the index case 2.5 months later.",
author = "Yoshizo Asano and Sadao Suga and Tetsushi Yoshikawa",
year = "1996",
month = "1",
day = "1",
doi = "10.1111/j.1442-200X.1996.tb03734.x",
language = "English",
volume = "38",
pages = "692--694",
journal = "Pediatrics International",
issn = "1328-8067",
publisher = "Wiley-Blackwell",
number = "6",

}

Comparison of specific immunities to varicella-zoster virus following post-exposure prophylaxis of varicella by oral acyclovir observed in a family. / Asano, Yoshizo; Suga, Sadao; Yoshikawa, Tetsushi.

In: Pediatrics International, Vol. 38, No. 6, 01.01.1996, p. 692-694.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of specific immunities to varicella-zoster virus following post-exposure prophylaxis of varicella by oral acyclovir observed in a family

AU - Asano, Yoshizo

AU - Suga, Sadao

AU - Yoshikawa, Tetsushi

PY - 1996/1/1

Y1 - 1996/1/1

N2 - An otherwise healthy 3-year-old girl developed severe varicella complicated by aseptic meningitis and received intravenous acyclovir (ACV) therapy. Her two siblings who were susceptible to varicella-zoster virus (VZV) and closely exposed to VZV in the family received oral ACV (45 or 54 mg/kg per day in four divided doses for 7 days) starting 8 days after onset of the index case for post-exposure prophylaxis of varicella. They showed only five or seven papules over the body without fever 12 days after onset of the index case, while they had one-third or half the level of antibody titer and equal sized skin reactions to VZV antigen of the index case 2.5 months later.

AB - An otherwise healthy 3-year-old girl developed severe varicella complicated by aseptic meningitis and received intravenous acyclovir (ACV) therapy. Her two siblings who were susceptible to varicella-zoster virus (VZV) and closely exposed to VZV in the family received oral ACV (45 or 54 mg/kg per day in four divided doses for 7 days) starting 8 days after onset of the index case for post-exposure prophylaxis of varicella. They showed only five or seven papules over the body without fever 12 days after onset of the index case, while they had one-third or half the level of antibody titer and equal sized skin reactions to VZV antigen of the index case 2.5 months later.

UR - http://www.scopus.com/inward/record.url?scp=0029912715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029912715&partnerID=8YFLogxK

U2 - 10.1111/j.1442-200X.1996.tb03734.x

DO - 10.1111/j.1442-200X.1996.tb03734.x

M3 - Article

VL - 38

SP - 692

EP - 694

JO - Pediatrics International

JF - Pediatrics International

SN - 1328-8067

IS - 6

ER -