Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis

Hiroaki Kusunoki, Masayasu Kusaka, Soichiro Kido, Ryo Yamauchi, Yoshinori Fujimura, Yasuyuki Watanabe, Michio Kobori, Hiroto Miwa, Toshihiko Tomita, Yongmin Kin, Kazutoshi Hori, Nobuo Tano, Kenji Sugimoto, Yoshihiro Nakamura, Kazuma Fujimoto, Noriko Oza, Aki Matsunobu, Naofumi Ono, Seisuke Fuyuno, Yoshikazu KinoshitaKyoichi Adachi, Mika Yuki, Tomoo Fujisawa, Ken Haruma

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9 Citations (Scopus)


Purpose: The purpose of this study was to compare the efficacy of proton pump inhibitor (PPI) with H2 receptor antagonist (H2RA) in treatment of upper abdominal symptoms. Methods: This was a multi-center, open study conducted at 102 hospitals in Japan. Patients with reflux esophagitis received famotidine 10 mg twice daily for 2 weeks, then omeprazole 10 mg once daily for 2 weeks. Thereafter, patients were switched to famotidine 10 mg twice daily for a third 2-weekperiod, provided those with a medical condition agreed to continue the study. Patients evaluated the treatment response to each gastrointestinal symptom using a predefined patient questionnaire and gastrointestinal symptom rating scale (GSRS). Results: 161 patients entered the study, of whom 8 were excluded from all analyses due to lack of participation following entry. Overall symptom improvement rate (n = 130) at week 4, after the 2-week omeprazole treatment, was 75.4% and this was significantly higher than that after the first 2-week famotidine treatment (41.5%) at week 2. In patients (n = 36) who completed 6 weeks of treatment, 2-week omeprazole treatment at week 4 showed a significantly higher overall symptom improvement rate compared with both the first 2-week and third 2-week famotidine treatments. Conclusions: Omeprazole was superior to famotidine for treatment of upper abdominal symptoms in patients with reflux esophagitis, which suggested that gastric acid might be a cause not only of reflux symptoms, but also of ulcer symptoms and dysmotility symptoms such as epigastric pain and feeling of fullness in reflux esophagitis.

Original languageEnglish
Pages (from-to)261-270
Number of pages10
JournalJournal of Gastroenterology
Issue number4
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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