Comparison of the gyro C1E3 and BioMedicus centrifugal pump performances during cardiopulmonary bypass

Tadashi Nakazawa, Yoshiyuki Takami, Kenzo Makinouchi, Joseph Gay, Deborah Taylor, Keishi Ueyama, Yukio Ohashi, Koji Kawahito, Eiki Tayama, Julie Glueck, Yukihiko Nosé

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3 Citations (Scopus)


The compact eccentric inlet port (C1E3) centrifugal blood pump was developed as a cardiopulmonary bypass (CPB) pump. The C1E3 pump incorporated a seal-less design with a blood stagnation free structure. The pump impeller was magnetically coupled to the driver magnet in a seal-less manner. To develop an atraumatic and antithrombogenic centrifugal pump without a shaft seal junction, a double pivot bearing system was introduced. Recently, a mass production model of the C1E3 was fabricated and evaluated. The ratio of the normalized index of hemolysis (NIH) of the C1E3 was 0.007 g/100 L, in comparison to the NIH of the BP-80, 0.018 g/100 L, each in a CPB condition of 5 L/rain against 325 mm Hg. Both pumps were compared in identical in vitro circuits. To further evaluate the pumps during cardiopulmonary bypass for reliability and function, 6 h of CPB was performed on each of S bovines using either the C1E3 or BP-80 centrifugal pump. The BP-80 and C1E3 provided pump flows of 50-60 ml/kg/min without incident. The hemodynamics were stable, and the hematology and biochemistry data were within normal ranges. There were no statistically significant differences between the 2 groups. Concerning the plasma free hemoglobin values, a mass production model of the C1E3 pump had the same hemolysis levels as the BP-80. Our preliminary studies reveal that the C1E3 pump is reliable. Also, the C1E3 will satisfy clinical requirements as a cardiopulmonary bypass pump.

Original languageEnglish
Pages (from-to)782-785
Number of pages4
JournalArtificial Organs
Issue number7
Publication statusPublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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