Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells

Naohisa Oku, Kozo Kaibuchi, Yasuo Fukumoto, Yuichi Hori, Hiroyuki Fujioka, Yoshimi Takai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-rasval12 complementary DNA (cDNA). The results indicate that the c-Ha-rasval12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalFEBS Letters
Volume269
Issue number1
DOIs
Publication statusPublished - 20-08-1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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