Comparison of tissue characteristics between acute coronary syndrome and stable angina pectoris: An integrated backscatter intravascular ultrasound analysis of culprit and non-culprit lesions

Hirohiko Ando, Tetsuya Amano, Tatsuaki Matsubara, Tadayuki Uetani, Michio Nanki, Nobuyuki Marui, Masataka Kato, Tomohiro Yoshida, Kiminobu Yokoi, Soichiro Kumagai, Satoshi Isobe, Hideki Ishii, Hideo Izawa, Toyoaki Murohara

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Abstract

Background: Patients with acute coronary syndrome (ACS) have multiple complex coronary plaques associated with plaque vulnerability. The present study assessed the tissue characteristics of coronary plaques between ACS and stable angina pectoris (SAP) of culprit and non-culprit lesions using integrated backscatter intravascular ultrasound (IB-IVUS). Methods and Results: IVUS was performed in 165 patients (40 patients with ACS) with 225 culprit (65 lesions in ACS) and 171 non-culprit lesions (42 lesions in ACS). The percentage of fibrous area (fibrous area/plaque area, %FIB) and the percentage of lipid area (lipid area/plaque area, %LIP) at the segment with minimal luminal area were calculated using IB-IVUS system. Culprit and non-culprit lesions with ACS showed a significant increase in %LIP (38±18 vs. 30±15%, P=0.002, and 38±21 vs. 32±17%, P=0.03, respectively) and a significant decrease in %FIB (59±15 vs. 63±12 %, P=0.04, and 57±18 vs. 62±14%, P=0.04, respectively) compared to those with SAP. On logistic regression analysis, not only culprit lesions but also non-culprit lesions with ACS patients were significantly associated with the lipid-rich plaque. Conclusions: Non-culprit coronary lesions with ACS patients are associated with the lipid-rich plaque, suggesting the extensive development of plaques instability in these patients.

Original languageEnglish
Pages (from-to)383-390
Number of pages8
JournalCirculation Journal
Volume75
Issue number2
DOIs
Publication statusPublished - 01-02-2011

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Stable Angina
Acute Coronary Syndrome
Lipids
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Ando, Hirohiko ; Amano, Tetsuya ; Matsubara, Tatsuaki ; Uetani, Tadayuki ; Nanki, Michio ; Marui, Nobuyuki ; Kato, Masataka ; Yoshida, Tomohiro ; Yokoi, Kiminobu ; Kumagai, Soichiro ; Isobe, Satoshi ; Ishii, Hideki ; Izawa, Hideo ; Murohara, Toyoaki. / Comparison of tissue characteristics between acute coronary syndrome and stable angina pectoris : An integrated backscatter intravascular ultrasound analysis of culprit and non-culprit lesions. In: Circulation Journal. 2011 ; Vol. 75, No. 2. pp. 383-390.
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title = "Comparison of tissue characteristics between acute coronary syndrome and stable angina pectoris: An integrated backscatter intravascular ultrasound analysis of culprit and non-culprit lesions",
abstract = "Background: Patients with acute coronary syndrome (ACS) have multiple complex coronary plaques associated with plaque vulnerability. The present study assessed the tissue characteristics of coronary plaques between ACS and stable angina pectoris (SAP) of culprit and non-culprit lesions using integrated backscatter intravascular ultrasound (IB-IVUS). Methods and Results: IVUS was performed in 165 patients (40 patients with ACS) with 225 culprit (65 lesions in ACS) and 171 non-culprit lesions (42 lesions in ACS). The percentage of fibrous area (fibrous area/plaque area, {\%}FIB) and the percentage of lipid area (lipid area/plaque area, {\%}LIP) at the segment with minimal luminal area were calculated using IB-IVUS system. Culprit and non-culprit lesions with ACS showed a significant increase in {\%}LIP (38±18 vs. 30±15{\%}, P=0.002, and 38±21 vs. 32±17{\%}, P=0.03, respectively) and a significant decrease in {\%}FIB (59±15 vs. 63±12 {\%}, P=0.04, and 57±18 vs. 62±14{\%}, P=0.04, respectively) compared to those with SAP. On logistic regression analysis, not only culprit lesions but also non-culprit lesions with ACS patients were significantly associated with the lipid-rich plaque. Conclusions: Non-culprit coronary lesions with ACS patients are associated with the lipid-rich plaque, suggesting the extensive development of plaques instability in these patients.",
author = "Hirohiko Ando and Tetsuya Amano and Tatsuaki Matsubara and Tadayuki Uetani and Michio Nanki and Nobuyuki Marui and Masataka Kato and Tomohiro Yoshida and Kiminobu Yokoi and Soichiro Kumagai and Satoshi Isobe and Hideki Ishii and Hideo Izawa and Toyoaki Murohara",
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Ando, H, Amano, T, Matsubara, T, Uetani, T, Nanki, M, Marui, N, Kato, M, Yoshida, T, Yokoi, K, Kumagai, S, Isobe, S, Ishii, H, Izawa, H & Murohara, T 2011, 'Comparison of tissue characteristics between acute coronary syndrome and stable angina pectoris: An integrated backscatter intravascular ultrasound analysis of culprit and non-culprit lesions', Circulation Journal, vol. 75, no. 2, pp. 383-390. https://doi.org/10.1253/circj.CJ-10-0815

Comparison of tissue characteristics between acute coronary syndrome and stable angina pectoris : An integrated backscatter intravascular ultrasound analysis of culprit and non-culprit lesions. / Ando, Hirohiko; Amano, Tetsuya; Matsubara, Tatsuaki; Uetani, Tadayuki; Nanki, Michio; Marui, Nobuyuki; Kato, Masataka; Yoshida, Tomohiro; Yokoi, Kiminobu; Kumagai, Soichiro; Isobe, Satoshi; Ishii, Hideki; Izawa, Hideo; Murohara, Toyoaki.

In: Circulation Journal, Vol. 75, No. 2, 01.02.2011, p. 383-390.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of tissue characteristics between acute coronary syndrome and stable angina pectoris

T2 - An integrated backscatter intravascular ultrasound analysis of culprit and non-culprit lesions

AU - Ando, Hirohiko

AU - Amano, Tetsuya

AU - Matsubara, Tatsuaki

AU - Uetani, Tadayuki

AU - Nanki, Michio

AU - Marui, Nobuyuki

AU - Kato, Masataka

AU - Yoshida, Tomohiro

AU - Yokoi, Kiminobu

AU - Kumagai, Soichiro

AU - Isobe, Satoshi

AU - Ishii, Hideki

AU - Izawa, Hideo

AU - Murohara, Toyoaki

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: Patients with acute coronary syndrome (ACS) have multiple complex coronary plaques associated with plaque vulnerability. The present study assessed the tissue characteristics of coronary plaques between ACS and stable angina pectoris (SAP) of culprit and non-culprit lesions using integrated backscatter intravascular ultrasound (IB-IVUS). Methods and Results: IVUS was performed in 165 patients (40 patients with ACS) with 225 culprit (65 lesions in ACS) and 171 non-culprit lesions (42 lesions in ACS). The percentage of fibrous area (fibrous area/plaque area, %FIB) and the percentage of lipid area (lipid area/plaque area, %LIP) at the segment with minimal luminal area were calculated using IB-IVUS system. Culprit and non-culprit lesions with ACS showed a significant increase in %LIP (38±18 vs. 30±15%, P=0.002, and 38±21 vs. 32±17%, P=0.03, respectively) and a significant decrease in %FIB (59±15 vs. 63±12 %, P=0.04, and 57±18 vs. 62±14%, P=0.04, respectively) compared to those with SAP. On logistic regression analysis, not only culprit lesions but also non-culprit lesions with ACS patients were significantly associated with the lipid-rich plaque. Conclusions: Non-culprit coronary lesions with ACS patients are associated with the lipid-rich plaque, suggesting the extensive development of plaques instability in these patients.

AB - Background: Patients with acute coronary syndrome (ACS) have multiple complex coronary plaques associated with plaque vulnerability. The present study assessed the tissue characteristics of coronary plaques between ACS and stable angina pectoris (SAP) of culprit and non-culprit lesions using integrated backscatter intravascular ultrasound (IB-IVUS). Methods and Results: IVUS was performed in 165 patients (40 patients with ACS) with 225 culprit (65 lesions in ACS) and 171 non-culprit lesions (42 lesions in ACS). The percentage of fibrous area (fibrous area/plaque area, %FIB) and the percentage of lipid area (lipid area/plaque area, %LIP) at the segment with minimal luminal area were calculated using IB-IVUS system. Culprit and non-culprit lesions with ACS showed a significant increase in %LIP (38±18 vs. 30±15%, P=0.002, and 38±21 vs. 32±17%, P=0.03, respectively) and a significant decrease in %FIB (59±15 vs. 63±12 %, P=0.04, and 57±18 vs. 62±14%, P=0.04, respectively) compared to those with SAP. On logistic regression analysis, not only culprit lesions but also non-culprit lesions with ACS patients were significantly associated with the lipid-rich plaque. Conclusions: Non-culprit coronary lesions with ACS patients are associated with the lipid-rich plaque, suggesting the extensive development of plaques instability in these patients.

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U2 - 10.1253/circj.CJ-10-0815

DO - 10.1253/circj.CJ-10-0815

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