Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action

Toshitaka Nabeshima, Yamada Shigeyuki Yamada, Sugimoto Akira Sugimoto, Matsuno Kiyoshi Matsuno, Kameyama Tsutomu Kameyama

Research output: Contribution to journalArticle

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Abstract

The antinociceptive, tolerance-developing and anti-withdrawal activities of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzo-thiadiazole] were investigated by comparing its effects with those of morphine and clonidine in tail-flick-, hot plate-, acetic acid-induced writhing-, and naloxone-precipitated withdrawal jumping-tests. The antinociceptive action of tizanidine was not altered by naloxone, while that of morphine was antagonized. Tolerance to the tizanidine-induced antinociceptive action and to motor incoordination was developed by successive administration of tizanidine. In the tizanidine-tolerant mice, the antinociceptive action of morphine was significantly decreased, but not sleeping time induced by pentobarbital. The action of tizanidine was not modified in the morphine-tolerant mice. Tizanidine failed to induce morphine-withdrawal jumping and to inhibit naloxone-precip3tated withdrawal jumping in the morphine-dependent mice. Cross tolerance to the antinociceptive action induced by tizanidine and clonidine was developed. These results suggest that α2-adrenoreceptors may be involved in the action mechanism of tizanidine, but not opioid receptors. Functional tolerance to tizanidine action may be developed by successive administration of tizanidine.

Original languageEnglish
Pages (from-to)835-841
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume25
Issue number4
DOIs
Publication statusPublished - 01-01-1986
Externally publishedYes

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Morphine
Naloxone
Clonidine
tizanidine
Thiadiazoles
Opioid Receptors
Pentobarbital
Ataxia
Acetic Acid
Tail

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Nabeshima, Toshitaka ; Shigeyuki Yamada, Yamada ; Akira Sugimoto, Sugimoto ; Kiyoshi Matsuno, Matsuno ; Tsutomu Kameyama, Kameyama. / Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action. In: Pharmacology, Biochemistry and Behavior. 1986 ; Vol. 25, No. 4. pp. 835-841.
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Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action. / Nabeshima, Toshitaka; Shigeyuki Yamada, Yamada; Akira Sugimoto, Sugimoto; Kiyoshi Matsuno, Matsuno; Tsutomu Kameyama, Kameyama.

In: Pharmacology, Biochemistry and Behavior, Vol. 25, No. 4, 01.01.1986, p. 835-841.

Research output: Contribution to journalArticle

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