TY - JOUR
T1 - Competitive NMDA antagonists enhance the catalepsy induced by Δ9-tetrahydrocannabinol in mice
AU - Kinoshita, Hiroshi
AU - Hasegawa, Takaaki
AU - Kameyama, Tsutomu
AU - Yamamoto, Ikuo
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This study was partly supported by Grants-in-Aid for Scientific Research (Nos. 03304036 and 00092093) from the Ministry of Education, Science and Culture, Japan, a Grant-in-Aid for Drug Abuse Research (No. 92-268) from the Ministry of Health and Welfare, Japan and a grant from the Suzuki Memorial Foundation.
PY - 1994/6/6
Y1 - 1994/6/6
N2 - Competitive N-methyl-d-aspartate (NMDA) receptor antagonists, such as CPP and AP-7, dose-dependently enhanced the catalepsy induced by Δ9-tetrahydrocannabinol (THC; 5 mg/kg) in mice, but CPP failed to enhance haloperidol-induced catalepsy. The enhancing effect of CPP on THC-induced catalepsy was dose-dependently blocked by a muscarinic receptor antagonist, scopolamine, and by dopamine D1 and D2 receptor agonists such as apomorphine, SKF 38393 and quinpirole. The effect of CPP was quite opposite to that of the noncompetitive NMDA receptor antagonist MK-801 [4]. Therefore, the THC-induced catalepsy model may be useful for distinguishing between both classes of NMDA receptor antagonists.
AB - Competitive N-methyl-d-aspartate (NMDA) receptor antagonists, such as CPP and AP-7, dose-dependently enhanced the catalepsy induced by Δ9-tetrahydrocannabinol (THC; 5 mg/kg) in mice, but CPP failed to enhance haloperidol-induced catalepsy. The enhancing effect of CPP on THC-induced catalepsy was dose-dependently blocked by a muscarinic receptor antagonist, scopolamine, and by dopamine D1 and D2 receptor agonists such as apomorphine, SKF 38393 and quinpirole. The effect of CPP was quite opposite to that of the noncompetitive NMDA receptor antagonist MK-801 [4]. Therefore, the THC-induced catalepsy model may be useful for distinguishing between both classes of NMDA receptor antagonists.
UR - http://www.scopus.com/inward/record.url?scp=0028306684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028306684&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)90129-5
DO - 10.1016/0304-3940(94)90129-5
M3 - Article
C2 - 7970141
AN - SCOPUS:0028306684
SN - 0304-3940
VL - 174
SP - 101
EP - 104
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -