Competitive NMDA antagonists enhance the catalepsy induced by Δ9-tetrahydrocannabinol in mice

Hiroshi Kinoshita, Takaaki Hasegawa, Tsutomu Kameyama, Ikuo Yamamoto, Toshitaka Nabeshima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Competitive N-methyl-d-aspartate (NMDA) receptor antagonists, such as CPP and AP-7, dose-dependently enhanced the catalepsy induced by Δ9-tetrahydrocannabinol (THC; 5 mg/kg) in mice, but CPP failed to enhance haloperidol-induced catalepsy. The enhancing effect of CPP on THC-induced catalepsy was dose-dependently blocked by a muscarinic receptor antagonist, scopolamine, and by dopamine D1 and D2 receptor agonists such as apomorphine, SKF 38393 and quinpirole. The effect of CPP was quite opposite to that of the noncompetitive NMDA receptor antagonist MK-801 [4]. Therefore, the THC-induced catalepsy model may be useful for distinguishing between both classes of NMDA receptor antagonists.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalNeuroscience Letters
Volume174
Issue number1
DOIs
Publication statusPublished - 06-06-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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