Competitive NMDA antagonists enhance the catalepsy induced by Δ9-tetrahydrocannabinol in mice

Hiroshi Kinoshita, Takaaki Hasegawa, Tsutomu Kameyama, Ikuo Yamamoto, Toshitaka Nabeshima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Competitive N-methyl-d-aspartate (NMDA) receptor antagonists, such as CPP and AP-7, dose-dependently enhanced the catalepsy induced by Δ9-tetrahydrocannabinol (THC; 5 mg/kg) in mice, but CPP failed to enhance haloperidol-induced catalepsy. The enhancing effect of CPP on THC-induced catalepsy was dose-dependently blocked by a muscarinic receptor antagonist, scopolamine, and by dopamine D1 and D2 receptor agonists such as apomorphine, SKF 38393 and quinpirole. The effect of CPP was quite opposite to that of the noncompetitive NMDA receptor antagonist MK-801 [4]. Therefore, the THC-induced catalepsy model may be useful for distinguishing between both classes of NMDA receptor antagonists.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalNeuroscience Letters
Volume174
Issue number1
DOIs
Publication statusPublished - 06-06-1994

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Catalepsy
Dronabinol
Aspartic Acid
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Dopamine D1 Receptors
Muscarinic Antagonists
Scopolamine Hydrobromide
Dizocilpine Maleate
Dopamine D2 Receptors
Apomorphine
Muscarinic Receptors
Haloperidol
aspartic acid receptor
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kinoshita, Hiroshi ; Hasegawa, Takaaki ; Kameyama, Tsutomu ; Yamamoto, Ikuo ; Nabeshima, Toshitaka. / Competitive NMDA antagonists enhance the catalepsy induced by Δ9-tetrahydrocannabinol in mice. In: Neuroscience Letters. 1994 ; Vol. 174, No. 1. pp. 101-104.
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Competitive NMDA antagonists enhance the catalepsy induced by Δ9-tetrahydrocannabinol in mice. / Kinoshita, Hiroshi; Hasegawa, Takaaki; Kameyama, Tsutomu; Yamamoto, Ikuo; Nabeshima, Toshitaka.

In: Neuroscience Letters, Vol. 174, No. 1, 06.06.1994, p. 101-104.

Research output: Contribution to journalArticle

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T1 - Competitive NMDA antagonists enhance the catalepsy induced by Δ9-tetrahydrocannabinol in mice

AU - Kinoshita, Hiroshi

AU - Hasegawa, Takaaki

AU - Kameyama, Tsutomu

AU - Yamamoto, Ikuo

AU - Nabeshima, Toshitaka

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