Complement C4d deposition in transplanted kidneys

Preliminary report on long-term graft survival

Nahoko Kawamura, Makoto Tomita, Midori Hasegawa, Kazutaka Murakami, Kunihiro Nabeshima, Hiroko Kushimoto, Masami Kasugai, Kazuo Takahashi, Yoshiyuki Hiki, Tsuneo Kinukawa, Nobumitsu Usuda, Satoshi Sugiyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of antibody-mediated rejection on long-term graft survival have not been fully investigated. The aim of this study is to clarify the influence on long-term survival of deposition of the complement split product C4d in allografts using polyclonal anti-C4d antibody. Inclusion criteria were recipients who underwent graft biopsy during acute deterioration of graft function within the first 2 yr after transplantation. Patients whose graft did not survive more than 1 yr and who received graft from an human leucocyte antigen (HLA)-identical sibling or an ABO-incompatible donor were excluded. Among the 92 recipients investigated, 22 (23.9%) had peritubular capillary C4d deposition, 15 (16.3%) had glomerular capillary C4d deposition and seven (7.6%) had both peritubular and glomerular capillary C4d deposition. Twenty of these 22 patients revealed acute cellular rejection, including borderline changes. There was no significant relationship between pathological severity of acute rejection and presence or absence of peritubular capillary C4d deposition. Graft survival was inferior in patients with peritubular capillary C4d deposition to that in patients without C4d deposition (p = 0.0419). Graft survival in patients with glomerular C4d deposition did not differ from that in patients without C4d deposition. In conclusion, C4d deposition in peritubular capillaries has a substantial impact on long-term graft survival.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalClinical Transplantation, Supplement
Volume19
Issue number14
Publication statusPublished - 27-07-2005

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Graft Survival
Kidney
Transplants
HLA Antigens
Allografts
complement C4d
Siblings
Anti-Idiotypic Antibodies
Transplantation
Tissue Donors
Biopsy
Survival
Antibodies
Rejection (Psychology)

All Science Journal Classification (ASJC) codes

  • Immunology
  • Transplantation

Cite this

Kawamura, N., Tomita, M., Hasegawa, M., Murakami, K., Nabeshima, K., Kushimoto, H., ... Sugiyama, S. (2005). Complement C4d deposition in transplanted kidneys: Preliminary report on long-term graft survival. Clinical Transplantation, Supplement, 19(14), 27-31.
Kawamura, Nahoko ; Tomita, Makoto ; Hasegawa, Midori ; Murakami, Kazutaka ; Nabeshima, Kunihiro ; Kushimoto, Hiroko ; Kasugai, Masami ; Takahashi, Kazuo ; Hiki, Yoshiyuki ; Kinukawa, Tsuneo ; Usuda, Nobumitsu ; Sugiyama, Satoshi. / Complement C4d deposition in transplanted kidneys : Preliminary report on long-term graft survival. In: Clinical Transplantation, Supplement. 2005 ; Vol. 19, No. 14. pp. 27-31.
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abstract = "The effects of antibody-mediated rejection on long-term graft survival have not been fully investigated. The aim of this study is to clarify the influence on long-term survival of deposition of the complement split product C4d in allografts using polyclonal anti-C4d antibody. Inclusion criteria were recipients who underwent graft biopsy during acute deterioration of graft function within the first 2 yr after transplantation. Patients whose graft did not survive more than 1 yr and who received graft from an human leucocyte antigen (HLA)-identical sibling or an ABO-incompatible donor were excluded. Among the 92 recipients investigated, 22 (23.9{\%}) had peritubular capillary C4d deposition, 15 (16.3{\%}) had glomerular capillary C4d deposition and seven (7.6{\%}) had both peritubular and glomerular capillary C4d deposition. Twenty of these 22 patients revealed acute cellular rejection, including borderline changes. There was no significant relationship between pathological severity of acute rejection and presence or absence of peritubular capillary C4d deposition. Graft survival was inferior in patients with peritubular capillary C4d deposition to that in patients without C4d deposition (p = 0.0419). Graft survival in patients with glomerular C4d deposition did not differ from that in patients without C4d deposition. In conclusion, C4d deposition in peritubular capillaries has a substantial impact on long-term graft survival.",
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Kawamura, N, Tomita, M, Hasegawa, M, Murakami, K, Nabeshima, K, Kushimoto, H, Kasugai, M, Takahashi, K, Hiki, Y, Kinukawa, T, Usuda, N & Sugiyama, S 2005, 'Complement C4d deposition in transplanted kidneys: Preliminary report on long-term graft survival', Clinical Transplantation, Supplement, vol. 19, no. 14, pp. 27-31.

Complement C4d deposition in transplanted kidneys : Preliminary report on long-term graft survival. / Kawamura, Nahoko; Tomita, Makoto; Hasegawa, Midori; Murakami, Kazutaka; Nabeshima, Kunihiro; Kushimoto, Hiroko; Kasugai, Masami; Takahashi, Kazuo; Hiki, Yoshiyuki; Kinukawa, Tsuneo; Usuda, Nobumitsu; Sugiyama, Satoshi.

In: Clinical Transplantation, Supplement, Vol. 19, No. 14, 27.07.2005, p. 27-31.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Complement C4d deposition in transplanted kidneys

T2 - Preliminary report on long-term graft survival

AU - Kawamura, Nahoko

AU - Tomita, Makoto

AU - Hasegawa, Midori

AU - Murakami, Kazutaka

AU - Nabeshima, Kunihiro

AU - Kushimoto, Hiroko

AU - Kasugai, Masami

AU - Takahashi, Kazuo

AU - Hiki, Yoshiyuki

AU - Kinukawa, Tsuneo

AU - Usuda, Nobumitsu

AU - Sugiyama, Satoshi

PY - 2005/7/27

Y1 - 2005/7/27

N2 - The effects of antibody-mediated rejection on long-term graft survival have not been fully investigated. The aim of this study is to clarify the influence on long-term survival of deposition of the complement split product C4d in allografts using polyclonal anti-C4d antibody. Inclusion criteria were recipients who underwent graft biopsy during acute deterioration of graft function within the first 2 yr after transplantation. Patients whose graft did not survive more than 1 yr and who received graft from an human leucocyte antigen (HLA)-identical sibling or an ABO-incompatible donor were excluded. Among the 92 recipients investigated, 22 (23.9%) had peritubular capillary C4d deposition, 15 (16.3%) had glomerular capillary C4d deposition and seven (7.6%) had both peritubular and glomerular capillary C4d deposition. Twenty of these 22 patients revealed acute cellular rejection, including borderline changes. There was no significant relationship between pathological severity of acute rejection and presence or absence of peritubular capillary C4d deposition. Graft survival was inferior in patients with peritubular capillary C4d deposition to that in patients without C4d deposition (p = 0.0419). Graft survival in patients with glomerular C4d deposition did not differ from that in patients without C4d deposition. In conclusion, C4d deposition in peritubular capillaries has a substantial impact on long-term graft survival.

AB - The effects of antibody-mediated rejection on long-term graft survival have not been fully investigated. The aim of this study is to clarify the influence on long-term survival of deposition of the complement split product C4d in allografts using polyclonal anti-C4d antibody. Inclusion criteria were recipients who underwent graft biopsy during acute deterioration of graft function within the first 2 yr after transplantation. Patients whose graft did not survive more than 1 yr and who received graft from an human leucocyte antigen (HLA)-identical sibling or an ABO-incompatible donor were excluded. Among the 92 recipients investigated, 22 (23.9%) had peritubular capillary C4d deposition, 15 (16.3%) had glomerular capillary C4d deposition and seven (7.6%) had both peritubular and glomerular capillary C4d deposition. Twenty of these 22 patients revealed acute cellular rejection, including borderline changes. There was no significant relationship between pathological severity of acute rejection and presence or absence of peritubular capillary C4d deposition. Graft survival was inferior in patients with peritubular capillary C4d deposition to that in patients without C4d deposition (p = 0.0419). Graft survival in patients with glomerular C4d deposition did not differ from that in patients without C4d deposition. In conclusion, C4d deposition in peritubular capillaries has a substantial impact on long-term graft survival.

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M3 - Article

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Kawamura N, Tomita M, Hasegawa M, Murakami K, Nabeshima K, Kushimoto H et al. Complement C4d deposition in transplanted kidneys: Preliminary report on long-term graft survival. Clinical Transplantation, Supplement. 2005 Jul 27;19(14):27-31.