Complete sequence of a conjugative IncN plasmid harboring blaKPC-2, blaSHV-12, and qnrS1 from an escherichia coli sequence type 648 Strain

Jun Jie Li, Chang Seop Lee, Ji Fang Sheng, Yohei Doi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We sequenced a novel conjugative blaKPC-2-harboring IncN plasmid, pYD626E, from an Escherichia coli sequence type 648 strain previously identified in Pittsburgh, Pennsylvania. pYD626E was 72,800 bp long and carried four β-lactamase genes, blaKPC-2, blaSHV-12, blaLAP-1, and blaTEM-1. In addition, it harbored qnrS1 (fluoroquinolone resistance) and dfrA14 (trimethoprim resistance). The plasmid profile and clinical history supported the in vivo transfer of this plasmid between Klebsiella pneumoniae and Escherichia coli.

Original languageEnglish
Pages (from-to)6974-6977
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number11
DOIs
Publication statusPublished - 01-11-2014

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Plasmids
Escherichia coli
Trimethoprim Resistance
Fluoroquinolones
Klebsiella pneumoniae
Genes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

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title = "Complete sequence of a conjugative IncN plasmid harboring blaKPC-2, blaSHV-12, and qnrS1 from an escherichia coli sequence type 648 Strain",
abstract = "We sequenced a novel conjugative blaKPC-2-harboring IncN plasmid, pYD626E, from an Escherichia coli sequence type 648 strain previously identified in Pittsburgh, Pennsylvania. pYD626E was 72,800 bp long and carried four β-lactamase genes, blaKPC-2, blaSHV-12, blaLAP-1, and blaTEM-1. In addition, it harbored qnrS1 (fluoroquinolone resistance) and dfrA14 (trimethoprim resistance). The plasmid profile and clinical history supported the in vivo transfer of this plasmid between Klebsiella pneumoniae and Escherichia coli.",
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Complete sequence of a conjugative IncN plasmid harboring blaKPC-2, blaSHV-12, and qnrS1 from an escherichia coli sequence type 648 Strain. / Li, Jun Jie; Lee, Chang Seop; Sheng, Ji Fang; Doi, Yohei.

In: Antimicrobial agents and chemotherapy, Vol. 58, No. 11, 01.11.2014, p. 6974-6977.

Research output: Contribution to journalArticle

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AU - Doi, Yohei

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AB - We sequenced a novel conjugative blaKPC-2-harboring IncN plasmid, pYD626E, from an Escherichia coli sequence type 648 strain previously identified in Pittsburgh, Pennsylvania. pYD626E was 72,800 bp long and carried four β-lactamase genes, blaKPC-2, blaSHV-12, blaLAP-1, and blaTEM-1. In addition, it harbored qnrS1 (fluoroquinolone resistance) and dfrA14 (trimethoprim resistance). The plasmid profile and clinical history supported the in vivo transfer of this plasmid between Klebsiella pneumoniae and Escherichia coli.

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