Complete sequence of a conjugative IncN plasmid harboring blaKPC-2, blaSHV-12, and qnrS1 from an escherichia coli sequence type 648 Strain

Jun Jie Li; Chang Seop Lee; Ji Fang Sheng; Yohei Doi

doi:10.1128/AAC.03632-14

Complete sequence of a conjugative IncN plasmid harboring bla_KPC-2, bla_SHV-12, and qnrS1 from an escherichia coli sequence type 648 Strain

Jun Jie Li, Chang Seop Lee, Ji Fang Sheng, Yohei Doi

Department of Microbiology

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

We sequenced a novel conjugative bla_KPC-2-harboring IncN plasmid, pYD626E, from an Escherichia coli sequence type 648 strain previously identified in Pittsburgh, Pennsylvania. pYD626E was 72,800 bp long and carried four β-lactamase genes, bla_KPC-2, bla_SHV-12, bla_LAP-1, and bla_TEM-1. In addition, it harbored qnrS1 (fluoroquinolone resistance) and dfrA14 (trimethoprim resistance). The plasmid profile and clinical history supported the in vivo transfer of this plasmid between Klebsiella pneumoniae and Escherichia coli.

Original language	English
Pages (from-to)	6974-6977
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	11
DOIs	https://doi.org/10.1128/AAC.03632-14
Publication status	Published - 01-11-2014

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All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

Cite this

Li, J. J., Lee, C. S., Sheng, J. F., & Doi, Y. (2014). Complete sequence of a conjugative IncN plasmid harboring bla_KPC-2, bla_SHV-12, and qnrS1 from an escherichia coli sequence type 648 Strain. Antimicrobial agents and chemotherapy, 58(11), 6974-6977. https://doi.org/10.1128/AAC.03632-14

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abstract = "We sequenced a novel conjugative blaKPC-2-harboring IncN plasmid, pYD626E, from an Escherichia coli sequence type 648 strain previously identified in Pittsburgh, Pennsylvania. pYD626E was 72,800 bp long and carried four β-lactamase genes, blaKPC-2, blaSHV-12, blaLAP-1, and blaTEM-1. In addition, it harbored qnrS1 (fluoroquinolone resistance) and dfrA14 (trimethoprim resistance). The plasmid profile and clinical history supported the in vivo transfer of this plasmid between Klebsiella pneumoniae and Escherichia coli.",

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10.1128/AAC.03632-14