Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty

Rie Ohashi, Keizo Takao, Tsuyoshi Miyakawa, Nobuyuki Shiina

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

RNG105 (also known as Caprin1) is a major RNA-binding protein in neuronal RNA granules, and is responsible for mRNA transport to dendrites and neuronal network formation. A recent study reported that a heterozygous mutation in the Rng105 gene was found in an autism spectrum disorder (ASD) patient, but it remains unclear whether there is a causal relation between RNG105 deficiency and ASD. Here, we subjected Rng105+/- mice to a comprehensive behavioral test battery, and revealed the influence of RNG105 deficiency on mouse behavior. Rng105+/- mice exhibited a reduced sociality in a home cage and a weak preference for social novelty. Consistently, the Rng105+/- mice also showed a weak preference for novel objects and novel place patterns. Furthermore, although the Rng105+/- mice exhibited normal memory acquisition, they tended to have relative difficulty in reversal learning in the spatial reference tasks. These findings suggest that the RNG105 heterozygous knockout leads to a reduction in sociality, response to novelty and flexibility in learning, which are implicated in ASD-like behavior.

Original languageEnglish
Article number20775
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 11-02-2016

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Interpersonal Relations
Reversal Learning
RNA-Binding Proteins
Dendrites
Learning
RNA
Messenger RNA
Mutation
Genes
Autism Spectrum Disorder

All Science Journal Classification (ASJC) codes

  • General

Cite this

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abstract = "RNG105 (also known as Caprin1) is a major RNA-binding protein in neuronal RNA granules, and is responsible for mRNA transport to dendrites and neuronal network formation. A recent study reported that a heterozygous mutation in the Rng105 gene was found in an autism spectrum disorder (ASD) patient, but it remains unclear whether there is a causal relation between RNG105 deficiency and ASD. Here, we subjected Rng105+/- mice to a comprehensive behavioral test battery, and revealed the influence of RNG105 deficiency on mouse behavior. Rng105+/- mice exhibited a reduced sociality in a home cage and a weak preference for social novelty. Consistently, the Rng105+/- mice also showed a weak preference for novel objects and novel place patterns. Furthermore, although the Rng105+/- mice exhibited normal memory acquisition, they tended to have relative difficulty in reversal learning in the spatial reference tasks. These findings suggest that the RNG105 heterozygous knockout leads to a reduction in sociality, response to novelty and flexibility in learning, which are implicated in ASD-like behavior.",
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Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice : Reduced social interaction and attenuated response to novelty. / Ohashi, Rie; Takao, Keizo; Miyakawa, Tsuyoshi; Shiina, Nobuyuki.

In: Scientific Reports, Vol. 6, 20775, 11.02.2016.

Research output: Contribution to journalArticle

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