Comprehensive behavioral phenotyping of calpastatin-knockout mice.

Ryuichi Nakajima, Keizo Takao, Shu Ming Huang, Jiro Takano, Nobuhisa Iwata, Tsuyoshi Miyakawa, Takaomi C. Saido

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely unknown. To examine the physiological roles of calpastatin, we subjected calpastatin-knockout mice to a comprehensive behavioral test battery. Calpastatin-knockout mice showed decreased locomotor activity under stressful environments, and decreased acoustic startle response, but we observed no significant change in hippocampus-dependent memory function. These results suggest that calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function.

Original languageEnglish
Pages (from-to)7
Number of pages1
JournalMolecular brain
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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