Comprehensive behavioral phenotyping of calpastatin-knockout mice.

Ryuichi Nakajima, Keizo Takao, Shu Ming Huang, Jiro Takano, Nobuhisa Iwata, Tsuyoshi Miyakawa, Takaomi C. Saido

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35 Citations (Scopus)


Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely unknown. To examine the physiological roles of calpastatin, we subjected calpastatin-knockout mice to a comprehensive behavioral test battery. Calpastatin-knockout mice showed decreased locomotor activity under stressful environments, and decreased acoustic startle response, but we observed no significant change in hippocampus-dependent memory function. These results suggest that calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function.

Original languageEnglish
Number of pages1
JournalMolecular brain
Publication statusPublished - 2008


All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Nakajima, R., Takao, K., Huang, S. M., Takano, J., Iwata, N., Miyakawa, T., & Saido, T. C. (2008). Comprehensive behavioral phenotyping of calpastatin-knockout mice. Molecular brain, 1.