COMT gene val158met polymorphism in patients with dyspeptic symptoms

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Fangyu Wang, Ichiro Hirata

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is unclear. Catechol-O-methyltransferase (COMT) has been an important enzyme in brain gut axis and pain sensitivity. Polymorphism in codon 158 of the COMT gene influences its activity. This study aimed to clarify the association between COMT polymorphism and dyspepsia in a Japanese population. Methodology: 91 dyspeptics and 94 non-dyspeptic subjects enrolled in this study. Dyspeptic symptoms were divided into 9 categories. COMT gene val158met polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequency of Met carriers was lower in over all dyspeptics than healthy control but the difference was not significant (OR=0.79, 95%CI=0.44-1.41) However, when the interaction between age, gender, H. pylori infection status and the number of COMT 158Met alleles was assessed using ANOVA, a slight interaction with gender + age + COMT polymorphism was found in relation to overall dyspeptics (p=0.0476) No correlation was found between COMT polymorphism and any of 9 symptoms. Conclusions: The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age. The role of genetics in the development of dyspepsia needs to further evaluation.

Original languageEnglish
Pages (from-to)979-982
Number of pages4
JournalHepato-Gastroenterology
Volume55
Issue number84
Publication statusPublished - 01-05-2008
Externally publishedYes

Fingerprint

Catechol O-Methyltransferase
Dyspepsia
Genes
Pylorus
Genetic Predisposition to Disease
Codon
Restriction Fragment Length Polymorphisms
Analysis of Variance
Alleles
Genotype
Pain
Polymerase Chain Reaction
Brain
Enzymes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tahara, T., Arisawa, T., Shibata, T., Nakamura, M., Wang, F., & Hirata, I. (2008). COMT gene val158met polymorphism in patients with dyspeptic symptoms. Hepato-Gastroenterology, 55(84), 979-982.
Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Wang, Fangyu ; Hirata, Ichiro. / COMT gene val158met polymorphism in patients with dyspeptic symptoms. In: Hepato-Gastroenterology. 2008 ; Vol. 55, No. 84. pp. 979-982.
@article{9b26cbae0cc849828b99b47003e7e08e,
title = "COMT gene val158met polymorphism in patients with dyspeptic symptoms",
abstract = "Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is unclear. Catechol-O-methyltransferase (COMT) has been an important enzyme in brain gut axis and pain sensitivity. Polymorphism in codon 158 of the COMT gene influences its activity. This study aimed to clarify the association between COMT polymorphism and dyspepsia in a Japanese population. Methodology: 91 dyspeptics and 94 non-dyspeptic subjects enrolled in this study. Dyspeptic symptoms were divided into 9 categories. COMT gene val158met polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequency of Met carriers was lower in over all dyspeptics than healthy control but the difference was not significant (OR=0.79, 95{\%}CI=0.44-1.41) However, when the interaction between age, gender, H. pylori infection status and the number of COMT 158Met alleles was assessed using ANOVA, a slight interaction with gender + age + COMT polymorphism was found in relation to overall dyspeptics (p=0.0476) No correlation was found between COMT polymorphism and any of 9 symptoms. Conclusions: The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age. The role of genetics in the development of dyspepsia needs to further evaluation.",
author = "Tomomitsu Tahara and Tomiyasu Arisawa and Tomoyuki Shibata and Masakatsu Nakamura and Fangyu Wang and Ichiro Hirata",
year = "2008",
month = "5",
day = "1",
language = "English",
volume = "55",
pages = "979--982",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "84",

}

Tahara, T, Arisawa, T, Shibata, T, Nakamura, M, Wang, F & Hirata, I 2008, 'COMT gene val158met polymorphism in patients with dyspeptic symptoms', Hepato-Gastroenterology, vol. 55, no. 84, pp. 979-982.

COMT gene val158met polymorphism in patients with dyspeptic symptoms. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Nakamura, Masakatsu; Wang, Fangyu; Hirata, Ichiro.

In: Hepato-Gastroenterology, Vol. 55, No. 84, 01.05.2008, p. 979-982.

Research output: Contribution to journalArticle

TY - JOUR

T1 - COMT gene val158met polymorphism in patients with dyspeptic symptoms

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Wang, Fangyu

AU - Hirata, Ichiro

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is unclear. Catechol-O-methyltransferase (COMT) has been an important enzyme in brain gut axis and pain sensitivity. Polymorphism in codon 158 of the COMT gene influences its activity. This study aimed to clarify the association between COMT polymorphism and dyspepsia in a Japanese population. Methodology: 91 dyspeptics and 94 non-dyspeptic subjects enrolled in this study. Dyspeptic symptoms were divided into 9 categories. COMT gene val158met polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequency of Met carriers was lower in over all dyspeptics than healthy control but the difference was not significant (OR=0.79, 95%CI=0.44-1.41) However, when the interaction between age, gender, H. pylori infection status and the number of COMT 158Met alleles was assessed using ANOVA, a slight interaction with gender + age + COMT polymorphism was found in relation to overall dyspeptics (p=0.0476) No correlation was found between COMT polymorphism and any of 9 symptoms. Conclusions: The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age. The role of genetics in the development of dyspepsia needs to further evaluation.

AB - Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is unclear. Catechol-O-methyltransferase (COMT) has been an important enzyme in brain gut axis and pain sensitivity. Polymorphism in codon 158 of the COMT gene influences its activity. This study aimed to clarify the association between COMT polymorphism and dyspepsia in a Japanese population. Methodology: 91 dyspeptics and 94 non-dyspeptic subjects enrolled in this study. Dyspeptic symptoms were divided into 9 categories. COMT gene val158met polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequency of Met carriers was lower in over all dyspeptics than healthy control but the difference was not significant (OR=0.79, 95%CI=0.44-1.41) However, when the interaction between age, gender, H. pylori infection status and the number of COMT 158Met alleles was assessed using ANOVA, a slight interaction with gender + age + COMT polymorphism was found in relation to overall dyspeptics (p=0.0476) No correlation was found between COMT polymorphism and any of 9 symptoms. Conclusions: The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age. The role of genetics in the development of dyspepsia needs to further evaluation.

UR - http://www.scopus.com/inward/record.url?scp=47149109516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47149109516&partnerID=8YFLogxK

M3 - Article

C2 - 18705311

AN - SCOPUS:47149109516

VL - 55

SP - 979

EP - 982

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 84

ER -

Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Hirata I. COMT gene val158met polymorphism in patients with dyspeptic symptoms. Hepato-Gastroenterology. 2008 May 1;55(84):979-982.