COMT gene val158met polymorphism influences the severity of intestinal metaplasia in H.Pylori infected older subjects

Tomomitsu Tahara, Tomoyuki Shibata, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiromi Yamashita, Hiroshi Nakano, Ichiro Hirata, Tomiyasu Arisatcv

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background /Aims: A complex interaction of host genetic and environmental factors may be relevant in the development of Helocobacter pylori (H. pylori)-re\sA> gastroduodenal diseases. Catechol-O-methyltransferase (COMT) is expressed catalyzes the methylation of various endobiotic and xenobiotic substances and thus might protect DNA from oxidative damage. We aimed to clarify the effect of COMT functional polymorphism on the severity of histological gastritis in a Japanese population. Methodology: 203 subjects were included in this study. Eestriction fragment length polymorphism analysis was performed for polymorphisms at codon 158 in the COMT gene. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results: COMT genotype distribution in the study subjects was 158Val/Val (51.2%), 84Val/Met (41.4%), and loMet/Met (7.4%). It was within the Hardy Weinberg equilibrium (p=0.73). In over all subjects, the degree of intestinal metaplasia tended to be lower among 158Met/Met when compared to Val/Val (Val/Val vs. Met/Met; 0.59±0.93 vs. 0.13±0.52, p=0.052). Among H.pylori infected subjects, the degree of intestinal metaplasia was significantly lower among 158Met carriers in 50 years or older age (Val/Val vs. Met carriers; 1.20±1.06 vs. 0.75±1.08, p=0.0436). No significant association was found between COMT genotypes and the degree of gastritis in different gender Conclusion: Our data suggest that COMT gene 158Met polymorphism is associate with a reduced risk of developing more severe intestinal metaplasia in H.pylori infected older subjects.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalHepato-Gastroenterology
Volume56
Issue number90
Publication statusPublished - 01-03-2009

Fingerprint

Catechol O-Methyltransferase
Pylorus
Metaplasia
Gastritis
Genes
Genotype
Xenobiotics
Gastric Mucosa
Codon
Methylation
DNA Damage
Population

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tahara, T., Shibata, T., Nakamura, M., Yoshioka, D., Okubo, M., Maruyama, N., ... Arisatcv, T. (2009). COMT gene val158met polymorphism influences the severity of intestinal metaplasia in H.Pylori infected older subjects. Hepato-Gastroenterology, 56(90), 411-415.
Tahara, Tomomitsu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Fujita, Hiroshi ; Nagasaka, Mitsuo ; Iwata, Masami ; Takahama, Kazuya ; Watanabe, Makoto ; Yamashita, Hiromi ; Nakano, Hiroshi ; Hirata, Ichiro ; Arisatcv, Tomiyasu. / COMT gene val158met polymorphism influences the severity of intestinal metaplasia in H.Pylori infected older subjects. In: Hepato-Gastroenterology. 2009 ; Vol. 56, No. 90. pp. 411-415.
@article{286dc84ff3ed4727b77745b3a62ae3d4,
title = "COMT gene val158met polymorphism influences the severity of intestinal metaplasia in H.Pylori infected older subjects",
abstract = "Background /Aims: A complex interaction of host genetic and environmental factors may be relevant in the development of Helocobacter pylori (H. pylori)-re\sA> gastroduodenal diseases. Catechol-O-methyltransferase (COMT) is expressed catalyzes the methylation of various endobiotic and xenobiotic substances and thus might protect DNA from oxidative damage. We aimed to clarify the effect of COMT functional polymorphism on the severity of histological gastritis in a Japanese population. Methodology: 203 subjects were included in this study. Eestriction fragment length polymorphism analysis was performed for polymorphisms at codon 158 in the COMT gene. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results: COMT genotype distribution in the study subjects was 158Val/Val (51.2{\%}), 84Val/Met (41.4{\%}), and loMet/Met (7.4{\%}). It was within the Hardy Weinberg equilibrium (p=0.73). In over all subjects, the degree of intestinal metaplasia tended to be lower among 158Met/Met when compared to Val/Val (Val/Val vs. Met/Met; 0.59±0.93 vs. 0.13±0.52, p=0.052). Among H.pylori infected subjects, the degree of intestinal metaplasia was significantly lower among 158Met carriers in 50 years or older age (Val/Val vs. Met carriers; 1.20±1.06 vs. 0.75±1.08, p=0.0436). No significant association was found between COMT genotypes and the degree of gastritis in different gender Conclusion: Our data suggest that COMT gene 158Met polymorphism is associate with a reduced risk of developing more severe intestinal metaplasia in H.pylori infected older subjects.",
author = "Tomomitsu Tahara and Tomoyuki Shibata and Masakatsu Nakamura and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Hiroshi Fujita and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Makoto Watanabe and Hiromi Yamashita and Hiroshi Nakano and Ichiro Hirata and Tomiyasu Arisatcv",
year = "2009",
month = "3",
day = "1",
language = "English",
volume = "56",
pages = "411--415",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "90",

}

Tahara, T, Shibata, T, Nakamura, M, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Fujita, H, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, M, Yamashita, H, Nakano, H, Hirata, I & Arisatcv, T 2009, 'COMT gene val158met polymorphism influences the severity of intestinal metaplasia in H.Pylori infected older subjects', Hepato-Gastroenterology, vol. 56, no. 90, pp. 411-415.

COMT gene val158met polymorphism influences the severity of intestinal metaplasia in H.Pylori infected older subjects. / Tahara, Tomomitsu; Shibata, Tomoyuki; Nakamura, Masakatsu; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Fujita, Hiroshi; Nagasaka, Mitsuo; Iwata, Masami; Takahama, Kazuya; Watanabe, Makoto; Yamashita, Hiromi; Nakano, Hiroshi; Hirata, Ichiro; Arisatcv, Tomiyasu.

In: Hepato-Gastroenterology, Vol. 56, No. 90, 01.03.2009, p. 411-415.

Research output: Contribution to journalArticle

TY - JOUR

T1 - COMT gene val158met polymorphism influences the severity of intestinal metaplasia in H.Pylori infected older subjects

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Yamashita, Hiromi

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

AU - Arisatcv, Tomiyasu

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Background /Aims: A complex interaction of host genetic and environmental factors may be relevant in the development of Helocobacter pylori (H. pylori)-re\sA> gastroduodenal diseases. Catechol-O-methyltransferase (COMT) is expressed catalyzes the methylation of various endobiotic and xenobiotic substances and thus might protect DNA from oxidative damage. We aimed to clarify the effect of COMT functional polymorphism on the severity of histological gastritis in a Japanese population. Methodology: 203 subjects were included in this study. Eestriction fragment length polymorphism analysis was performed for polymorphisms at codon 158 in the COMT gene. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results: COMT genotype distribution in the study subjects was 158Val/Val (51.2%), 84Val/Met (41.4%), and loMet/Met (7.4%). It was within the Hardy Weinberg equilibrium (p=0.73). In over all subjects, the degree of intestinal metaplasia tended to be lower among 158Met/Met when compared to Val/Val (Val/Val vs. Met/Met; 0.59±0.93 vs. 0.13±0.52, p=0.052). Among H.pylori infected subjects, the degree of intestinal metaplasia was significantly lower among 158Met carriers in 50 years or older age (Val/Val vs. Met carriers; 1.20±1.06 vs. 0.75±1.08, p=0.0436). No significant association was found between COMT genotypes and the degree of gastritis in different gender Conclusion: Our data suggest that COMT gene 158Met polymorphism is associate with a reduced risk of developing more severe intestinal metaplasia in H.pylori infected older subjects.

AB - Background /Aims: A complex interaction of host genetic and environmental factors may be relevant in the development of Helocobacter pylori (H. pylori)-re\sA> gastroduodenal diseases. Catechol-O-methyltransferase (COMT) is expressed catalyzes the methylation of various endobiotic and xenobiotic substances and thus might protect DNA from oxidative damage. We aimed to clarify the effect of COMT functional polymorphism on the severity of histological gastritis in a Japanese population. Methodology: 203 subjects were included in this study. Eestriction fragment length polymorphism analysis was performed for polymorphisms at codon 158 in the COMT gene. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. Results: COMT genotype distribution in the study subjects was 158Val/Val (51.2%), 84Val/Met (41.4%), and loMet/Met (7.4%). It was within the Hardy Weinberg equilibrium (p=0.73). In over all subjects, the degree of intestinal metaplasia tended to be lower among 158Met/Met when compared to Val/Val (Val/Val vs. Met/Met; 0.59±0.93 vs. 0.13±0.52, p=0.052). Among H.pylori infected subjects, the degree of intestinal metaplasia was significantly lower among 158Met carriers in 50 years or older age (Val/Val vs. Met carriers; 1.20±1.06 vs. 0.75±1.08, p=0.0436). No significant association was found between COMT genotypes and the degree of gastritis in different gender Conclusion: Our data suggest that COMT gene 158Met polymorphism is associate with a reduced risk of developing more severe intestinal metaplasia in H.pylori infected older subjects.

UR - http://www.scopus.com/inward/record.url?scp=67649232750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649232750&partnerID=8YFLogxK

M3 - Article

VL - 56

SP - 411

EP - 415

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 90

ER -