COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder

A diffusion tensor imaging study

Kenji Hayashi, Reiji Yoshimura, Shingo Kakeda, Taro Kishi, Osamu Abe, Wakako Umene-Nakano, Asuka Katsuki, Hikaru Hori, Atsuko Ikenouchi-Sugita, Keita Watanabe, Satoru Ide, Issei Ueda, Junji Moriya, Nakao Iwata, Yukunori Korogi, Marek Kubicki, Jun Nakamura

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes in patients with major depressive disorder (MDD) and healthy subjects using diffusion tensor imaging (DTI). We studied 30 patients with MDD (17 males and 13 females, with mean age ± standard deviation [SD] =44±12 years) and 30 sex- and age-matched healthy controls (17 males and 13 females, aged 44±13 years). Using DTI analysis with a tract-based spatial statistics (TBSS) approach, we investigated the differences in fractional anisotropy, radial diffusivity, and axial diffusivity distribution among the three groups (patients with the COMT gene Val158Met, those with the BDNF gene Val66Met, and the healthy subjects). In a voxel-wise-based group comparison, we found significant decreases in fractional anisotropy and axial diffusivity within the temporal lobe white matter in the Met-carriers with MDD compared with the controls (P,0.05). No correlations in fractional anisotropy, axial diffusivity, or radial diffusivity were observed between the MDD patients and the controls, either among those with the BDNF Val/Val genotype or among the BDNF Met-carriers. These results suggest an association between the COMT gene Val158Met and the white matter abnormalities found in the temporal lobe of patients with MDD.

Original languageEnglish
Pages (from-to)1183-1190
Number of pages8
JournalNeuropsychiatric Disease and Treatment
Volume10
DOIs
Publication statusPublished - 25-06-2014

Fingerprint

Catechol O-Methyltransferase
Diffusion Tensor Imaging
Brain-Derived Neurotrophic Factor
Major Depressive Disorder
Temporal Lobe
Anisotropy
Genes
Healthy Volunteers
Therapeutics
Genotype
White Matter

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hayashi, Kenji ; Yoshimura, Reiji ; Kakeda, Shingo ; Kishi, Taro ; Abe, Osamu ; Umene-Nakano, Wakako ; Katsuki, Asuka ; Hori, Hikaru ; Ikenouchi-Sugita, Atsuko ; Watanabe, Keita ; Ide, Satoru ; Ueda, Issei ; Moriya, Junji ; Iwata, Nakao ; Korogi, Yukunori ; Kubicki, Marek ; Nakamura, Jun. / COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder : A diffusion tensor imaging study. In: Neuropsychiatric Disease and Treatment. 2014 ; Vol. 10. pp. 1183-1190.
@article{6b97a77cfa2d4f428205ca3c96d3091f,
title = "COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-na{\"i}ve major depressive disorder: A diffusion tensor imaging study",
abstract = "We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes in patients with major depressive disorder (MDD) and healthy subjects using diffusion tensor imaging (DTI). We studied 30 patients with MDD (17 males and 13 females, with mean age ± standard deviation [SD] =44±12 years) and 30 sex- and age-matched healthy controls (17 males and 13 females, aged 44±13 years). Using DTI analysis with a tract-based spatial statistics (TBSS) approach, we investigated the differences in fractional anisotropy, radial diffusivity, and axial diffusivity distribution among the three groups (patients with the COMT gene Val158Met, those with the BDNF gene Val66Met, and the healthy subjects). In a voxel-wise-based group comparison, we found significant decreases in fractional anisotropy and axial diffusivity within the temporal lobe white matter in the Met-carriers with MDD compared with the controls (P,0.05). No correlations in fractional anisotropy, axial diffusivity, or radial diffusivity were observed between the MDD patients and the controls, either among those with the BDNF Val/Val genotype or among the BDNF Met-carriers. These results suggest an association between the COMT gene Val158Met and the white matter abnormalities found in the temporal lobe of patients with MDD.",
author = "Kenji Hayashi and Reiji Yoshimura and Shingo Kakeda and Taro Kishi and Osamu Abe and Wakako Umene-Nakano and Asuka Katsuki and Hikaru Hori and Atsuko Ikenouchi-Sugita and Keita Watanabe and Satoru Ide and Issei Ueda and Junji Moriya and Nakao Iwata and Yukunori Korogi and Marek Kubicki and Jun Nakamura",
year = "2014",
month = "6",
day = "25",
doi = "10.2147/NDT.S61275",
language = "English",
volume = "10",
pages = "1183--1190",
journal = "Neuropsychiatric Disease and Treatment",
issn = "1176-6328",
publisher = "Dove Medical Press Ltd.",

}

Hayashi, K, Yoshimura, R, Kakeda, S, Kishi, T, Abe, O, Umene-Nakano, W, Katsuki, A, Hori, H, Ikenouchi-Sugita, A, Watanabe, K, Ide, S, Ueda, I, Moriya, J, Iwata, N, Korogi, Y, Kubicki, M & Nakamura, J 2014, 'COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: A diffusion tensor imaging study', Neuropsychiatric Disease and Treatment, vol. 10, pp. 1183-1190. https://doi.org/10.2147/NDT.S61275

COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder : A diffusion tensor imaging study. / Hayashi, Kenji; Yoshimura, Reiji; Kakeda, Shingo; Kishi, Taro; Abe, Osamu; Umene-Nakano, Wakako; Katsuki, Asuka; Hori, Hikaru; Ikenouchi-Sugita, Atsuko; Watanabe, Keita; Ide, Satoru; Ueda, Issei; Moriya, Junji; Iwata, Nakao; Korogi, Yukunori; Kubicki, Marek; Nakamura, Jun.

In: Neuropsychiatric Disease and Treatment, Vol. 10, 25.06.2014, p. 1183-1190.

Research output: Contribution to journalArticle

TY - JOUR

T1 - COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder

T2 - A diffusion tensor imaging study

AU - Hayashi, Kenji

AU - Yoshimura, Reiji

AU - Kakeda, Shingo

AU - Kishi, Taro

AU - Abe, Osamu

AU - Umene-Nakano, Wakako

AU - Katsuki, Asuka

AU - Hori, Hikaru

AU - Ikenouchi-Sugita, Atsuko

AU - Watanabe, Keita

AU - Ide, Satoru

AU - Ueda, Issei

AU - Moriya, Junji

AU - Iwata, Nakao

AU - Korogi, Yukunori

AU - Kubicki, Marek

AU - Nakamura, Jun

PY - 2014/6/25

Y1 - 2014/6/25

N2 - We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes in patients with major depressive disorder (MDD) and healthy subjects using diffusion tensor imaging (DTI). We studied 30 patients with MDD (17 males and 13 females, with mean age ± standard deviation [SD] =44±12 years) and 30 sex- and age-matched healthy controls (17 males and 13 females, aged 44±13 years). Using DTI analysis with a tract-based spatial statistics (TBSS) approach, we investigated the differences in fractional anisotropy, radial diffusivity, and axial diffusivity distribution among the three groups (patients with the COMT gene Val158Met, those with the BDNF gene Val66Met, and the healthy subjects). In a voxel-wise-based group comparison, we found significant decreases in fractional anisotropy and axial diffusivity within the temporal lobe white matter in the Met-carriers with MDD compared with the controls (P,0.05). No correlations in fractional anisotropy, axial diffusivity, or radial diffusivity were observed between the MDD patients and the controls, either among those with the BDNF Val/Val genotype or among the BDNF Met-carriers. These results suggest an association between the COMT gene Val158Met and the white matter abnormalities found in the temporal lobe of patients with MDD.

AB - We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes in patients with major depressive disorder (MDD) and healthy subjects using diffusion tensor imaging (DTI). We studied 30 patients with MDD (17 males and 13 females, with mean age ± standard deviation [SD] =44±12 years) and 30 sex- and age-matched healthy controls (17 males and 13 females, aged 44±13 years). Using DTI analysis with a tract-based spatial statistics (TBSS) approach, we investigated the differences in fractional anisotropy, radial diffusivity, and axial diffusivity distribution among the three groups (patients with the COMT gene Val158Met, those with the BDNF gene Val66Met, and the healthy subjects). In a voxel-wise-based group comparison, we found significant decreases in fractional anisotropy and axial diffusivity within the temporal lobe white matter in the Met-carriers with MDD compared with the controls (P,0.05). No correlations in fractional anisotropy, axial diffusivity, or radial diffusivity were observed between the MDD patients and the controls, either among those with the BDNF Val/Val genotype or among the BDNF Met-carriers. These results suggest an association between the COMT gene Val158Met and the white matter abnormalities found in the temporal lobe of patients with MDD.

UR - http://www.scopus.com/inward/record.url?scp=84903374137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903374137&partnerID=8YFLogxK

U2 - 10.2147/NDT.S61275

DO - 10.2147/NDT.S61275

M3 - Article

VL - 10

SP - 1183

EP - 1190

JO - Neuropsychiatric Disease and Treatment

JF - Neuropsychiatric Disease and Treatment

SN - 1176-6328

ER -