Concentration of roxithromycin in the lesions of acne vulgaris

H. Akamatsu; T. Horio

doi:10.1177/147323000102900611

Concentration of roxithromycin in the lesions of acne vulgaris

H. Akamatsu, T. Horio

Applied Cell and Regenerative Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Roxithromycin, a macrolide antibiotic, is used in the treatment of acne vulgaris, although there have been no reports on its concentration in lesions when administered orally. We investigated the concentration of roxithromycin in acne vulgaris lesions in five patients who received 150 mg roxithromycin orally twice daily for 2 weeks. The mean concentration of roxithromycin in the lesions was 0.54 μg/ml. These results suggest that roxithromycin accumulates at therapeutic levels in the pilosebaceous system.

Original language	English
Pages (from-to)	537-540
Number of pages	4
Journal	Journal of International Medical Research
Volume	29
Issue number	6
DOIs	https://doi.org/10.1177/147323000102900611
Publication status	Published - 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Cell Biology
Biochemistry, medical

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abstract = "Roxithromycin, a macrolide antibiotic, is used in the treatment of acne vulgaris, although there have been no reports on its concentration in lesions when administered orally. We investigated the concentration of roxithromycin in acne vulgaris lesions in five patients who received 150 mg roxithromycin orally twice daily for 2 weeks. The mean concentration of roxithromycin in the lesions was 0.54 μg/ml. These results suggest that roxithromycin accumulates at therapeutic levels in the pilosebaceous system.",

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