TY - JOUR
T1 - Concentration of roxithromycin in the lesions of acne vulgaris
AU - Akamatsu, H.
AU - Horio, T.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Roxithromycin, a macrolide antibiotic, is used in the treatment of acne vulgaris, although there have been no reports on its concentration in lesions when administered orally. We investigated the concentration of roxithromycin in acne vulgaris lesions in five patients who received 150 mg roxithromycin orally twice daily for 2 weeks. The mean concentration of roxithromycin in the lesions was 0.54 μg/ml. These results suggest that roxithromycin accumulates at therapeutic levels in the pilosebaceous system.
AB - Roxithromycin, a macrolide antibiotic, is used in the treatment of acne vulgaris, although there have been no reports on its concentration in lesions when administered orally. We investigated the concentration of roxithromycin in acne vulgaris lesions in five patients who received 150 mg roxithromycin orally twice daily for 2 weeks. The mean concentration of roxithromycin in the lesions was 0.54 μg/ml. These results suggest that roxithromycin accumulates at therapeutic levels in the pilosebaceous system.
UR - http://www.scopus.com/inward/record.url?scp=0035677832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035677832&partnerID=8YFLogxK
U2 - 10.1177/147323000102900611
DO - 10.1177/147323000102900611
M3 - Article
C2 - 11803739
AN - SCOPUS:0035677832
VL - 29
SP - 537
EP - 540
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 6
ER -