Concentration of transforming growth factor β2 in aqueous humor

Naoki Yamamoto, Koichiro Itonaga, Tohru Marunouchi, Kiyoyuki Majima

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62 Citations (Scopus)


The total transforming growth factor (TGF) β2 concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-β2 concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-β2.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalOphthalmic Research
Issue number1
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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