Concentration of transforming growth factor β2 in aqueous humor

Naoki Yamamoto; Koichiro Itonaga; Tohru Marunouchi; Kiyoyuki Majima

doi:10.1159/000083019

Concentration of transforming growth factor β₂ in aqueous humor

Naoki Yamamoto, Koichiro Itonaga, Tohru Marunouchi, Kiyoyuki Majima

Support Office for Bioresource Research

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

The total transforming growth factor (TGF) β₂ concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-β₂ concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-β₂.

Original language	English
Pages (from-to)	29-33
Number of pages	5
Journal	Ophthalmic Research
Volume	37
Issue number	1
DOIs	https://doi.org/10.1159/000083019
Publication status	Published - 2005

All Science Journal Classification (ASJC) codes

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000083019

Cite this

@article{35e6576e54d44d5b91072c08559275a0,

title = "Concentration of transforming growth factor β2 in aqueous humor",

abstract = "The total transforming growth factor (TGF) β2 concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-β2 concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-β2.",

author = "Naoki Yamamoto and Koichiro Itonaga and Tohru Marunouchi and Kiyoyuki Majima",

year = "2005",

doi = "10.1159/000083019",

language = "English",

volume = "37",

pages = "29--33",

journal = "Ophthalmic Research",

issn = "0030-3747",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Concentration of transforming growth factor β2 in aqueous humor

AU - Yamamoto, Naoki

AU - Itonaga, Koichiro

AU - Marunouchi, Tohru

AU - Majima, Kiyoyuki

PY - 2005

Y1 - 2005

N2 - The total transforming growth factor (TGF) β2 concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-β2 concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-β2.

AB - The total transforming growth factor (TGF) β2 concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-β2 concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-β2.

UR - http://www.scopus.com/inward/record.url?scp=18644379971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18644379971&partnerID=8YFLogxK

U2 - 10.1159/000083019

DO - 10.1159/000083019

M3 - Article

C2 - 15637419

AN - SCOPUS:18644379971

SN - 0030-3747

VL - 37

SP - 29

EP - 33

JO - Ophthalmic Research

JF - Ophthalmic Research

IS - 1

ER -