Confocal endomicroscopy for the diagnosis of gastric cancer in vivo

S. Kitabatake, Y. Niwa, R. Miyahara, A. Ohashi, T. Matsuura, Y. Iguchi, Y. Shimoyama, T. Nagasaka, O. Maeda, T. Ando, N. Ohmiya, A. Itoh, Y. Hirooka, H. Goto

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Background and study aims: Advances in endoscopy have led to imaging of the details of the gastric mucosa, but the histological diagnosis usually has to be confirmed by endoscopic biopsy. A method of confocal endomicroscopy that has recently been developed allows the observation of living cells in vivo. Several investigators have reported that the technique is of value, but there have as yet been no studies describing its application in gastric cancer. Patients and methods: Twenty-seven patients with early gastric cancer underwent confocal endomicroscopy (Pentax EG-3870CIK; Pentax, Tokyo, Japan). After intravenous administration of fluorescein sodium, confocal images obtained from the normal mucosa and from cancerous lesions were interpreted by two pathologists independently and compared with the histological findings, including CD34 immunostaining of biopsy specimens or resected specimens from the same sites. Results: Fluorescein yielded high-quality confocal images of the gastric mucosa; if cancer could be targeted (59%) images were mostly graded good. The images corresponded to the hematoxylin-eosin staining of transverse sections of specimens from the same sites. In the results for the interpretation by the two pathologists, the accuracy for the diagnosis of gastric cancer was 94.2% (pathologist A), and 96.2% (pathologist B), respectively. The accuracy decreased substantially when poor images and inaccessible lesions were included. Conclusions: Confocal endomicroscopy is useful in the diagnosis of gastric cancer but good quality images cannot always be obtained. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.

Original languageEnglish
Pages (from-to)1110-1114
Number of pages5
JournalEndoscopy
Volume38
Issue number11
DOIs
Publication statusPublished - 01-11-2006
Externally publishedYes

Fingerprint

Stomach Neoplasms
Biopsy
Gastric Mucosa
Fluorescein
Tokyo
Hematoxylin
Eosine Yellowish-(YS)
Intravenous Administration
Endoscopy
Japan
Mucous Membrane
Research Personnel
Observation
Staining and Labeling
Pathologists
Neoplasms

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kitabatake, S., Niwa, Y., Miyahara, R., Ohashi, A., Matsuura, T., Iguchi, Y., ... Goto, H. (2006). Confocal endomicroscopy for the diagnosis of gastric cancer in vivo. Endoscopy, 38(11), 1110-1114. https://doi.org/10.1055/s-2006-944855
Kitabatake, S. ; Niwa, Y. ; Miyahara, R. ; Ohashi, A. ; Matsuura, T. ; Iguchi, Y. ; Shimoyama, Y. ; Nagasaka, T. ; Maeda, O. ; Ando, T. ; Ohmiya, N. ; Itoh, A. ; Hirooka, Y. ; Goto, H. / Confocal endomicroscopy for the diagnosis of gastric cancer in vivo. In: Endoscopy. 2006 ; Vol. 38, No. 11. pp. 1110-1114.
@article{f4b31586ff9940b692845abdc47d3232,
title = "Confocal endomicroscopy for the diagnosis of gastric cancer in vivo",
abstract = "Background and study aims: Advances in endoscopy have led to imaging of the details of the gastric mucosa, but the histological diagnosis usually has to be confirmed by endoscopic biopsy. A method of confocal endomicroscopy that has recently been developed allows the observation of living cells in vivo. Several investigators have reported that the technique is of value, but there have as yet been no studies describing its application in gastric cancer. Patients and methods: Twenty-seven patients with early gastric cancer underwent confocal endomicroscopy (Pentax EG-3870CIK; Pentax, Tokyo, Japan). After intravenous administration of fluorescein sodium, confocal images obtained from the normal mucosa and from cancerous lesions were interpreted by two pathologists independently and compared with the histological findings, including CD34 immunostaining of biopsy specimens or resected specimens from the same sites. Results: Fluorescein yielded high-quality confocal images of the gastric mucosa; if cancer could be targeted (59{\%}) images were mostly graded good. The images corresponded to the hematoxylin-eosin staining of transverse sections of specimens from the same sites. In the results for the interpretation by the two pathologists, the accuracy for the diagnosis of gastric cancer was 94.2{\%} (pathologist A), and 96.2{\%} (pathologist B), respectively. The accuracy decreased substantially when poor images and inaccessible lesions were included. Conclusions: Confocal endomicroscopy is useful in the diagnosis of gastric cancer but good quality images cannot always be obtained. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.",
author = "S. Kitabatake and Y. Niwa and R. Miyahara and A. Ohashi and T. Matsuura and Y. Iguchi and Y. Shimoyama and T. Nagasaka and O. Maeda and T. Ando and N. Ohmiya and A. Itoh and Y. Hirooka and H. Goto",
year = "2006",
month = "11",
day = "1",
doi = "10.1055/s-2006-944855",
language = "English",
volume = "38",
pages = "1110--1114",
journal = "Endoscopy",
issn = "0013-726X",
publisher = "Georg Thieme Verlag",
number = "11",

}

Kitabatake, S, Niwa, Y, Miyahara, R, Ohashi, A, Matsuura, T, Iguchi, Y, Shimoyama, Y, Nagasaka, T, Maeda, O, Ando, T, Ohmiya, N, Itoh, A, Hirooka, Y & Goto, H 2006, 'Confocal endomicroscopy for the diagnosis of gastric cancer in vivo', Endoscopy, vol. 38, no. 11, pp. 1110-1114. https://doi.org/10.1055/s-2006-944855

Confocal endomicroscopy for the diagnosis of gastric cancer in vivo. / Kitabatake, S.; Niwa, Y.; Miyahara, R.; Ohashi, A.; Matsuura, T.; Iguchi, Y.; Shimoyama, Y.; Nagasaka, T.; Maeda, O.; Ando, T.; Ohmiya, N.; Itoh, A.; Hirooka, Y.; Goto, H.

In: Endoscopy, Vol. 38, No. 11, 01.11.2006, p. 1110-1114.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Confocal endomicroscopy for the diagnosis of gastric cancer in vivo

AU - Kitabatake, S.

AU - Niwa, Y.

AU - Miyahara, R.

AU - Ohashi, A.

AU - Matsuura, T.

AU - Iguchi, Y.

AU - Shimoyama, Y.

AU - Nagasaka, T.

AU - Maeda, O.

AU - Ando, T.

AU - Ohmiya, N.

AU - Itoh, A.

AU - Hirooka, Y.

AU - Goto, H.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Background and study aims: Advances in endoscopy have led to imaging of the details of the gastric mucosa, but the histological diagnosis usually has to be confirmed by endoscopic biopsy. A method of confocal endomicroscopy that has recently been developed allows the observation of living cells in vivo. Several investigators have reported that the technique is of value, but there have as yet been no studies describing its application in gastric cancer. Patients and methods: Twenty-seven patients with early gastric cancer underwent confocal endomicroscopy (Pentax EG-3870CIK; Pentax, Tokyo, Japan). After intravenous administration of fluorescein sodium, confocal images obtained from the normal mucosa and from cancerous lesions were interpreted by two pathologists independently and compared with the histological findings, including CD34 immunostaining of biopsy specimens or resected specimens from the same sites. Results: Fluorescein yielded high-quality confocal images of the gastric mucosa; if cancer could be targeted (59%) images were mostly graded good. The images corresponded to the hematoxylin-eosin staining of transverse sections of specimens from the same sites. In the results for the interpretation by the two pathologists, the accuracy for the diagnosis of gastric cancer was 94.2% (pathologist A), and 96.2% (pathologist B), respectively. The accuracy decreased substantially when poor images and inaccessible lesions were included. Conclusions: Confocal endomicroscopy is useful in the diagnosis of gastric cancer but good quality images cannot always be obtained. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.

AB - Background and study aims: Advances in endoscopy have led to imaging of the details of the gastric mucosa, but the histological diagnosis usually has to be confirmed by endoscopic biopsy. A method of confocal endomicroscopy that has recently been developed allows the observation of living cells in vivo. Several investigators have reported that the technique is of value, but there have as yet been no studies describing its application in gastric cancer. Patients and methods: Twenty-seven patients with early gastric cancer underwent confocal endomicroscopy (Pentax EG-3870CIK; Pentax, Tokyo, Japan). After intravenous administration of fluorescein sodium, confocal images obtained from the normal mucosa and from cancerous lesions were interpreted by two pathologists independently and compared with the histological findings, including CD34 immunostaining of biopsy specimens or resected specimens from the same sites. Results: Fluorescein yielded high-quality confocal images of the gastric mucosa; if cancer could be targeted (59%) images were mostly graded good. The images corresponded to the hematoxylin-eosin staining of transverse sections of specimens from the same sites. In the results for the interpretation by the two pathologists, the accuracy for the diagnosis of gastric cancer was 94.2% (pathologist A), and 96.2% (pathologist B), respectively. The accuracy decreased substantially when poor images and inaccessible lesions were included. Conclusions: Confocal endomicroscopy is useful in the diagnosis of gastric cancer but good quality images cannot always be obtained. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.

UR - http://www.scopus.com/inward/record.url?scp=33751521826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751521826&partnerID=8YFLogxK

U2 - 10.1055/s-2006-944855

DO - 10.1055/s-2006-944855

M3 - Article

VL - 38

SP - 1110

EP - 1114

JO - Endoscopy

JF - Endoscopy

SN - 0013-726X

IS - 11

ER -

Kitabatake S, Niwa Y, Miyahara R, Ohashi A, Matsuura T, Iguchi Y et al. Confocal endomicroscopy for the diagnosis of gastric cancer in vivo. Endoscopy. 2006 Nov 1;38(11):1110-1114. https://doi.org/10.1055/s-2006-944855