Congenital cytomegalovirus in Japan: More than 2 year follow up of infected newborns

the Japanese Congenital Cytomegalovirus Study Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The aim of this study was to evaluate the outcome of congenital cytomegalovirus (CMV) infection identified on urine-filter screening assay at >2 years’ follow up, and to observe the clinical outcomes after anti-CMV treatment. Methods: Sixty of 72 congenital CMV patients were enrolled and clinically observed for >2 years. Forty-three were asymptomatic at birth; seven were symptomatic at birth but untreated with anti-CMV drugs; and 10 were symptomatic and treated with anti-CMV drugs. Results: Of the 43 asymptomatic patients, three developed hearing loss or language disability for which association with congenital CMV has been repeatedly reported, and two had neurological sequelae of which the etiology was unclear, indicating that the rate of CMV-associated late-onset sequelae was 7–12%. All seven symptomatic infants without treatment developed sequelae, while three of the 10 treated patients were free from any sequelae. Conclusions: The rate of late-onset sequelae observed in Japan is similar to that reported in the USA and Europe. The treatment of symptomatic patients with antiviral agents results in favorable clinical outcomes. Thus, newborn urine–filter paper screening of congenital CMV infection is warranted.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalPediatrics International
Volume60
Issue number1
DOIs
Publication statusPublished - 01-01-2018

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Cytomegalovirus
Japan
Newborn Infant
Cytomegalovirus Infections
Parturition
Hearing Loss
Pharmaceutical Preparations
Antiviral Agents
Language
Therapeutics
Urine

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

the Japanese Congenital Cytomegalovirus Study Group. / Congenital cytomegalovirus in Japan : More than 2 year follow up of infected newborns. In: Pediatrics International. 2018 ; Vol. 60, No. 1. pp. 57-62.
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abstract = "Background: The aim of this study was to evaluate the outcome of congenital cytomegalovirus (CMV) infection identified on urine-filter screening assay at >2 years’ follow up, and to observe the clinical outcomes after anti-CMV treatment. Methods: Sixty of 72 congenital CMV patients were enrolled and clinically observed for >2 years. Forty-three were asymptomatic at birth; seven were symptomatic at birth but untreated with anti-CMV drugs; and 10 were symptomatic and treated with anti-CMV drugs. Results: Of the 43 asymptomatic patients, three developed hearing loss or language disability for which association with congenital CMV has been repeatedly reported, and two had neurological sequelae of which the etiology was unclear, indicating that the rate of CMV-associated late-onset sequelae was 7–12{\%}. All seven symptomatic infants without treatment developed sequelae, while three of the 10 treated patients were free from any sequelae. Conclusions: The rate of late-onset sequelae observed in Japan is similar to that reported in the USA and Europe. The treatment of symptomatic patients with antiviral agents results in favorable clinical outcomes. Thus, newborn urine–filter paper screening of congenital CMV infection is warranted.",
author = "{the Japanese Congenital Cytomegalovirus Study Group} and Shin Koyano and Ichiro Morioka and Akira Oka and Hiroyuki Moriuchi and Kimisato Asano and Yushi Ito and Tetsushi Yoshikawa and Hideto Yamada and Tatsuo Suzutani and Naoki Inoue",
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Congenital cytomegalovirus in Japan : More than 2 year follow up of infected newborns. / the Japanese Congenital Cytomegalovirus Study Group.

In: Pediatrics International, Vol. 60, No. 1, 01.01.2018, p. 57-62.

Research output: Contribution to journalArticle

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T1 - Congenital cytomegalovirus in Japan

T2 - More than 2 year follow up of infected newborns

AU - the Japanese Congenital Cytomegalovirus Study Group

AU - Koyano, Shin

AU - Morioka, Ichiro

AU - Oka, Akira

AU - Moriuchi, Hiroyuki

AU - Asano, Kimisato

AU - Ito, Yushi

AU - Yoshikawa, Tetsushi

AU - Yamada, Hideto

AU - Suzutani, Tatsuo

AU - Inoue, Naoki

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The aim of this study was to evaluate the outcome of congenital cytomegalovirus (CMV) infection identified on urine-filter screening assay at >2 years’ follow up, and to observe the clinical outcomes after anti-CMV treatment. Methods: Sixty of 72 congenital CMV patients were enrolled and clinically observed for >2 years. Forty-three were asymptomatic at birth; seven were symptomatic at birth but untreated with anti-CMV drugs; and 10 were symptomatic and treated with anti-CMV drugs. Results: Of the 43 asymptomatic patients, three developed hearing loss or language disability for which association with congenital CMV has been repeatedly reported, and two had neurological sequelae of which the etiology was unclear, indicating that the rate of CMV-associated late-onset sequelae was 7–12%. All seven symptomatic infants without treatment developed sequelae, while three of the 10 treated patients were free from any sequelae. Conclusions: The rate of late-onset sequelae observed in Japan is similar to that reported in the USA and Europe. The treatment of symptomatic patients with antiviral agents results in favorable clinical outcomes. Thus, newborn urine–filter paper screening of congenital CMV infection is warranted.

AB - Background: The aim of this study was to evaluate the outcome of congenital cytomegalovirus (CMV) infection identified on urine-filter screening assay at >2 years’ follow up, and to observe the clinical outcomes after anti-CMV treatment. Methods: Sixty of 72 congenital CMV patients were enrolled and clinically observed for >2 years. Forty-three were asymptomatic at birth; seven were symptomatic at birth but untreated with anti-CMV drugs; and 10 were symptomatic and treated with anti-CMV drugs. Results: Of the 43 asymptomatic patients, three developed hearing loss or language disability for which association with congenital CMV has been repeatedly reported, and two had neurological sequelae of which the etiology was unclear, indicating that the rate of CMV-associated late-onset sequelae was 7–12%. All seven symptomatic infants without treatment developed sequelae, while three of the 10 treated patients were free from any sequelae. Conclusions: The rate of late-onset sequelae observed in Japan is similar to that reported in the USA and Europe. The treatment of symptomatic patients with antiviral agents results in favorable clinical outcomes. Thus, newborn urine–filter paper screening of congenital CMV infection is warranted.

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