TY - JOUR
T1 - Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder
T2 - Systematic Review and Meta-Analysis
AU - Maeyama, Kaori
AU - Tomioka, Kazumi
AU - Nagase, Hiroaki
AU - Yoshioka, Mieko
AU - Takagi, Yasuko
AU - Kato, Takeshi
AU - Mizobuchi, Masami
AU - Kitayama, Shinji
AU - Takada, Satoshi
AU - Nagai, Masashi
AU - Sakakibara, Nana
AU - Nishiyama, Masahiro
AU - Taniguchi-Ikeda, Mariko
AU - Morioka, Ichiro
AU - Iijima, Kazumoto
AU - Nishimura, Noriyuki
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.
AB - Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.
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U2 - 10.1007/s10803-017-3412-x
DO - 10.1007/s10803-017-3412-x
M3 - Article
C2 - 29185167
AN - SCOPUS:85035151229
SN - 0162-3257
VL - 48
SP - 1483
EP - 1491
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 5
ER -