Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis

Kaori Maeyama, Kazumi Tomioka, Hiroaki Nagase, Mieko Yoshioka, Yasuko Takagi, Takeshi Kato, Masami Mizobuchi, Shinji Kitayama, Satoshi Takada, Masashi Nagai, Nana Sakakibara, Masahiro Nishiyama, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

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Abstract

Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

Original languageEnglish
Pages (from-to)1483-1491
Number of pages9
JournalJournal of Autism and Developmental Disorders
Volume48
Issue number5
DOIs
Publication statusPublished - 01-05-2018

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All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology

Cite this

Maeyama, K., Tomioka, K., Nagase, H., Yoshioka, M., Takagi, Y., Kato, T., Mizobuchi, M., Kitayama, S., Takada, S., Nagai, M., Sakakibara, N., Nishiyama, M., Taniguchi-Ikeda, M., Morioka, I., Iijima, K., & Nishimura, N. (2018). Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis. Journal of Autism and Developmental Disorders, 48(5), 1483-1491. https://doi.org/10.1007/s10803-017-3412-x