Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis

Kaori Maeyama; Kazumi Tomioka; Hiroaki Nagase; Mieko Yoshioka; Yasuko Takagi; Takeshi Kato; Masami Mizobuchi; Shinji Kitayama; Satoshi Takada; Masashi Nagai; Nana Sakakibara; Masahiro Nishiyama; Mariko Taniguchi-Ikeda; Ichiro Morioka; Kazumoto Iijima; Noriyuki Nishimura

doi:10.1007/s10803-017-3412-x

Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis

Kaori Maeyama
, Kazumi Tomioka
, Hiroaki Nagase
, Mieko Yoshioka
, Yasuko Takagi
, Takeshi Kato
, Masami Mizobuchi
, Shinji Kitayama
, Satoshi Takada
, Masashi Nagai
, Nana Sakakibara
, Masahiro Nishiyama
, Mariko Taniguchi-Ikeda
, Ichiro Morioka
, Kazumoto Iijima
, Noriyuki Nishimura

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

Original language	English
Pages (from-to)	1483-1491
Number of pages	9
Journal	Journal of Autism and Developmental Disorders
Volume	48
Issue number	5
DOIs	https://doi.org/10.1007/s10803-017-3412-x
Publication status	Published - 01-05-2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Developmental and Educational Psychology

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Maeyama, K., Tomioka, K., Nagase, H., Yoshioka, M., Takagi, Y., Kato, T., Mizobuchi, M., Kitayama, S., Takada, S., Nagai, M., Sakakibara, N., Nishiyama, M., Taniguchi-Ikeda, M., Morioka, I., Iijima, K., & Nishimura, N. (2018). Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis. Journal of Autism and Developmental Disorders, 48(5), 1483-1491. https://doi.org/10.1007/s10803-017-3412-x

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title = "Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis",

abstract = "Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95\% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.",

keywords = "ASD, Congenital CMV infection, Maternal immune activation, Neurodevelopmental disorder, Prenatal environment, Risk factor",

author = "Kaori Maeyama and Kazumi Tomioka and Hiroaki Nagase and Mieko Yoshioka and Yasuko Takagi and Takeshi Kato and Masami Mizobuchi and Shinji Kitayama and Satoshi Takada and Masashi Nagai and Nana Sakakibara and Masahiro Nishiyama and Mariko Taniguchi-Ikeda and Ichiro Morioka and Kazumoto Iijima and Noriyuki Nishimura",

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Maeyama, K, Tomioka, K, Nagase, H, Yoshioka, M, Takagi, Y, Kato, T, Mizobuchi, M, Kitayama, S, Takada, S, Nagai, M, Sakakibara, N, Nishiyama, M, Taniguchi-Ikeda, M, Morioka, I, Iijima, K & Nishimura, N 2018, 'Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis', Journal of Autism and Developmental Disorders, vol. 48, no. 5, pp. 1483-1491. https://doi.org/10.1007/s10803-017-3412-x

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T2 - Systematic Review and Meta-Analysis

AU - Maeyama, Kaori

AU - Tomioka, Kazumi

AU - Nagase, Hiroaki

AU - Yoshioka, Mieko

AU - Takagi, Yasuko

AU - Kato, Takeshi

AU - Mizobuchi, Masami

AU - Kitayama, Shinji

AU - Takada, Satoshi

AU - Nagai, Masashi

AU - Sakakibara, Nana

AU - Nishiyama, Masahiro

AU - Taniguchi-Ikeda, Mariko

AU - Morioka, Ichiro

AU - Iijima, Kazumoto

AU - Nishimura, Noriyuki

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

AB - Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

KW - ASD

KW - Congenital CMV infection

KW - Maternal immune activation

KW - Neurodevelopmental disorder

KW - Prenatal environment

KW - Risk factor

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JF - Journal of Autism and Developmental Disorders

IS - 5

ER -

Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis

Abstract

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