Congenital Thrombophilia in Patients With Superior Mesenteric Venous Thrombosis or Portal Vein Thrombosis

Ikejiri Makoto, Masanobu Usui, Hideo Wada, Takeshi Matsumoto, Kohshi Ohishi, Akihiro Shindo, Yoshiki Yamashita, Kaname Nakatani, Shigehisa Tamaki, Hidekazu Tomimoto, Shuji Isaji

Research output: Contribution to journalArticlepeer-review

Abstract

We explored the relationship between abdominal vein thromboses, including portal vein thrombosis (PVT) and superior mesenteric vein thrombosis (SMVT), and thrombophilia. The frequency of thrombophilia, such as antithrombin (AT), protein C (PC), or protein S (PS) gene mutations, was examined in 21 patients with PVT, 6 patients with SMVT, and 6 patients with both PVT and SMVT. Low levels of AT, PC, or PS were frequently detected in patients with PVT or mesenteric vein thrombosis, and 4 mutations in the PS gene, 3 mutations in the PC gene, and 2 mutations in AT the gene were detected. Protein S Tokushima was detected in 3 of 4 patients with a PS gene mutation and was associated with 2 other PS gene mutations. The onset of PVT or SMVT was almost idiopathic in patients with congenital thrombophilia. Both PVT and SMVT were frequently caused by an AT, a PC, or a PS mutation, and the onset of these thromboses due to thrombophilia was frequently idiopathic.

Original languageEnglish
Pages (from-to)1117-1121
Number of pages5
JournalClinical and Applied Thrombosis/Hemostasis
Volume24
Issue number7
DOIs
Publication statusPublished - 01-10-2018

All Science Journal Classification (ASJC) codes

  • Hematology

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