Congestion of superior mesenteric veins and small bowel mucosal injury after endoscopic treatment of esophageal varices in patients with portal hypertension

Hidenori Toyoda, Makoto Nakao, Yozo Ogura, Kenji Takagi, Keisuke Osakabe, Yuji Horiguchi, Hideo Imai, Hiroshi Sakamoto, Hiroyuki Uno, Masahito Kamiya, Hiroshi Nakano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated treatment-induced changes in venous return from the small bowel and small bowel intestinal mucosal injury induced by the treatment of esophageal varices in patients with portal hypertension. A total of 14 patients (age 59.8 ± 9.5 years, five women and 9 men) who received prophylactic treatment of esophageal varices between December 1998 and March 1999 were investigated. Diamine oxidase (DAO) activity was measured before and after treatment. Changes in blood flow of the portal and superior mesenteric veins were investigated by Doppler ultrasonography in six patients. A significant decrease in DAO activity was observed three days after treatment (11.5 ± 1.6 units/liter prior to treatment versus 8.6 ± 1.6 units/liter three days after treatment; P < 0.001). Decreases in superior mesenteric and portal venous flow velocity were observed in four and three patients, respectively. In two patients with an increase in the cross-sectional area of the superior mesenteric vein with delayed venous return, a marked decrease in DAO activity was observed three days after treatment. In patients with portal hypertension, rapid reduction of pooling of portal flow caused by the treatment of esophageal varices can induce transient congestion of the mesenteric venous system which can produce some small bowel mucosal injury.

Original languageEnglish
Pages (from-to)2353-2359
Number of pages7
JournalDigestive Diseases and Sciences
Volume46
Issue number11
DOIs
Publication statusPublished - 20-11-2001

Fingerprint

Mesenteric Veins
Esophageal and Gastric Varices
Portal Hypertension
Wounds and Injuries
Amine Oxidase (Copper-Containing)
Therapeutics
Doppler Ultrasonography
Hyperemia

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Toyoda, Hidenori ; Nakao, Makoto ; Ogura, Yozo ; Takagi, Kenji ; Osakabe, Keisuke ; Horiguchi, Yuji ; Imai, Hideo ; Sakamoto, Hiroshi ; Uno, Hiroyuki ; Kamiya, Masahito ; Nakano, Hiroshi. / Congestion of superior mesenteric veins and small bowel mucosal injury after endoscopic treatment of esophageal varices in patients with portal hypertension. In: Digestive Diseases and Sciences. 2001 ; Vol. 46, No. 11. pp. 2353-2359.
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Congestion of superior mesenteric veins and small bowel mucosal injury after endoscopic treatment of esophageal varices in patients with portal hypertension. / Toyoda, Hidenori; Nakao, Makoto; Ogura, Yozo; Takagi, Kenji; Osakabe, Keisuke; Horiguchi, Yuji; Imai, Hideo; Sakamoto, Hiroshi; Uno, Hiroyuki; Kamiya, Masahito; Nakano, Hiroshi.

In: Digestive Diseases and Sciences, Vol. 46, No. 11, 20.11.2001, p. 2353-2359.

Research output: Contribution to journalArticle

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AU - Toyoda, Hidenori

AU - Nakao, Makoto

AU - Ogura, Yozo

AU - Takagi, Kenji

AU - Osakabe, Keisuke

AU - Horiguchi, Yuji

AU - Imai, Hideo

AU - Sakamoto, Hiroshi

AU - Uno, Hiroyuki

AU - Kamiya, Masahito

AU - Nakano, Hiroshi

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