Conservation and diversification of MHC class I and its related molecules in vertebrates

Keiichiro Hashimoto, Kazuhiko Okamura, Hisateru Yamaguchi, Mitsuru Ototake, Teruyuki Nakanishi, Yoshikazu Kurosawa

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

The elucidation of the complete peptide-binding domains of the highly polymorphic shark MHC class I genes offered us an opportunity to examine the characteristics of their predicted protein products in the light of the latest advance in the structural studies of the MHC class I molecules. The results suggest that the fundamental characteristics in the T-cell recognition of the MHC class I molecule/peptide complex are expected to have been established at the early stage of the vertebrate evolution. The elucidation of the typical classical class I molecules from fishes and also of some MHC class I-related molecules may help us to explore the common denominator of the ancient class I molecules.

Original languageEnglish
Pages (from-to)81-100
Number of pages20
JournalImmunological Reviews
Volume167
DOIs
Publication statusPublished - 01-01-1999

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Hashimoto, K., Okamura, K., Yamaguchi, H., Ototake, M., Nakanishi, T., & Kurosawa, Y. (1999). Conservation and diversification of MHC class I and its related molecules in vertebrates. Immunological Reviews, 167, 81-100. https://doi.org/10.1111/j.1600-065X.1999.tb01384.x