Conservation and diversification of MHC class I and its related molecules in vertebrates

Keiichiro Hashimoto, Kazuhiko Okamura, Hisateru Yamaguchi, Mitsuru Ototake, Teruyuki Nakanishi, Yoshikazu Kurosawa

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)


The elucidation of the complete peptide-binding domains of the highly polymorphic shark MHC class I genes offered us an opportunity to examine the characteristics of their predicted protein products in the light of the latest advance in the structural studies of the MHC class I molecules. The results suggest that the fundamental characteristics in the T-cell recognition of the MHC class I molecule/peptide complex are expected to have been established at the early stage of the vertebrate evolution. The elucidation of the typical classical class I molecules from fishes and also of some MHC class I-related molecules may help us to explore the common denominator of the ancient class I molecules.

Original languageEnglish
Pages (from-to)81-100
Number of pages20
JournalImmunological Reviews
Publication statusPublished - 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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