Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments

Fumio Takizawa, Erling Olaf Koppang, Maki Ohtani, Teruyuki Nakanishi, Keiichiro Hashimoto, Uwe Fischer, J・m Dijkstra

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Rainbow trout and Atlantic salmon interleukin-4/13A (IL-4/13A) genes were identified. They were found expressed at high level in thymus, gill, and skin, in concert with the transcription factor gene GATA-3. High expression levels of IL-4, IL-13, and GATA-3 were also detected in murine thymus, suggesting similar importance of the fish and mammalian homologues for early T cell development. In mammals, combined high expression of IL-4/13 and GATA-3 in tissues other than thymus is mostly indicative of Th2 responses. Th2-skewage may protect fish skin and gill from parasites and from damage by inflammatory Th1 and Th17 responses. The immune milieus of fish gill and skin are relevant to aquaculture, because these tissues are preferred sites for vaccine administration. The similarities between the immune milieus of fish gill and thymus may reflect an evolutionary relationship, since these tissues map close together lining the gill cavity. Expression patterns of IL-4/13A and interferon gamma (IFN-γ) in isolated trout gill cells and pronephrocytes were consistent with Th2 identity of IL-4/13A.

Original languageEnglish
Pages (from-to)1360-1368
Number of pages9
JournalMolecular Immunology
Volume48
Issue number12-13
DOIs
Publication statusPublished - 01-07-2011

Fingerprint

Interleukin-4
Fishes
Skin
Thymus Gland
Interleukin-13
GATA3 Transcription Factor
GATA Transcription Factors
Salmo salar
Aquaculture
Trout
Oncorhynchus mykiss
Genes
Interferon-gamma
Mammals
Parasites
Vaccines
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology

Cite this

@article{d7c7429b0d75462faeecc51a20b1a99f,
title = "Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments",
abstract = "Rainbow trout and Atlantic salmon interleukin-4/13A (IL-4/13A) genes were identified. They were found expressed at high level in thymus, gill, and skin, in concert with the transcription factor gene GATA-3. High expression levels of IL-4, IL-13, and GATA-3 were also detected in murine thymus, suggesting similar importance of the fish and mammalian homologues for early T cell development. In mammals, combined high expression of IL-4/13 and GATA-3 in tissues other than thymus is mostly indicative of Th2 responses. Th2-skewage may protect fish skin and gill from parasites and from damage by inflammatory Th1 and Th17 responses. The immune milieus of fish gill and skin are relevant to aquaculture, because these tissues are preferred sites for vaccine administration. The similarities between the immune milieus of fish gill and thymus may reflect an evolutionary relationship, since these tissues map close together lining the gill cavity. Expression patterns of IL-4/13A and interferon gamma (IFN-γ) in isolated trout gill cells and pronephrocytes were consistent with Th2 identity of IL-4/13A.",
author = "Fumio Takizawa and Koppang, {Erling Olaf} and Maki Ohtani and Teruyuki Nakanishi and Keiichiro Hashimoto and Uwe Fischer and J・m Dijkstra",
year = "2011",
month = "7",
day = "1",
doi = "10.1016/j.molimm.2011.02.014",
language = "English",
volume = "48",
pages = "1360--1368",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Elsevier Limited",
number = "12-13",

}

Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments. / Takizawa, Fumio; Koppang, Erling Olaf; Ohtani, Maki; Nakanishi, Teruyuki; Hashimoto, Keiichiro; Fischer, Uwe; Dijkstra, J・m.

In: Molecular Immunology, Vol. 48, No. 12-13, 01.07.2011, p. 1360-1368.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments

AU - Takizawa, Fumio

AU - Koppang, Erling Olaf

AU - Ohtani, Maki

AU - Nakanishi, Teruyuki

AU - Hashimoto, Keiichiro

AU - Fischer, Uwe

AU - Dijkstra, J・m

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Rainbow trout and Atlantic salmon interleukin-4/13A (IL-4/13A) genes were identified. They were found expressed at high level in thymus, gill, and skin, in concert with the transcription factor gene GATA-3. High expression levels of IL-4, IL-13, and GATA-3 were also detected in murine thymus, suggesting similar importance of the fish and mammalian homologues for early T cell development. In mammals, combined high expression of IL-4/13 and GATA-3 in tissues other than thymus is mostly indicative of Th2 responses. Th2-skewage may protect fish skin and gill from parasites and from damage by inflammatory Th1 and Th17 responses. The immune milieus of fish gill and skin are relevant to aquaculture, because these tissues are preferred sites for vaccine administration. The similarities between the immune milieus of fish gill and thymus may reflect an evolutionary relationship, since these tissues map close together lining the gill cavity. Expression patterns of IL-4/13A and interferon gamma (IFN-γ) in isolated trout gill cells and pronephrocytes were consistent with Th2 identity of IL-4/13A.

AB - Rainbow trout and Atlantic salmon interleukin-4/13A (IL-4/13A) genes were identified. They were found expressed at high level in thymus, gill, and skin, in concert with the transcription factor gene GATA-3. High expression levels of IL-4, IL-13, and GATA-3 were also detected in murine thymus, suggesting similar importance of the fish and mammalian homologues for early T cell development. In mammals, combined high expression of IL-4/13 and GATA-3 in tissues other than thymus is mostly indicative of Th2 responses. Th2-skewage may protect fish skin and gill from parasites and from damage by inflammatory Th1 and Th17 responses. The immune milieus of fish gill and skin are relevant to aquaculture, because these tissues are preferred sites for vaccine administration. The similarities between the immune milieus of fish gill and thymus may reflect an evolutionary relationship, since these tissues map close together lining the gill cavity. Expression patterns of IL-4/13A and interferon gamma (IFN-γ) in isolated trout gill cells and pronephrocytes were consistent with Th2 identity of IL-4/13A.

UR - http://www.scopus.com/inward/record.url?scp=79957874689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957874689&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2011.02.014

DO - 10.1016/j.molimm.2011.02.014

M3 - Article

VL - 48

SP - 1360

EP - 1368

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 12-13

ER -