TY - JOUR
T1 - Consumption of soy foods and the risk of breast cancer
T2 - Findings from the Japan Collaborative Cohort (JACC) Study
AU - Nishio, Kazuko
AU - Niwa, Yoshimitsu
AU - Toyoshima, Hideaki
AU - Tamakoshi, Koji
AU - Kondo, Takaaki
AU - Yatsuya, Hiroshi
AU - Yamamoto, Akio
AU - Suzuki, Sadao
AU - Tokudome, Shinkan
AU - Lin, Yingsong
AU - Wakai, Kenji
AU - Hamajima, Nobuyuki
AU - Tamakoshi, Akiko
PY - 2007/10
Y1 - 2007/10
N2 - Objective: The association between a lower incidence of breast cancer within the Asian population and the consumption of a diet high in soy has recently been the subject of much attention. To examine whether soy foods really have protective effects against breast cancer and how their influence on breast cancer is modified according to menopausal status, we conducted a population-based, prospective cohort study in Japan. Methods: We analyzed the data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 30,454 women aged 40-79 years, completed a questionnaire on diet and other lifestyle features. Hazard ratios (HRs) were computed to examine the association between soy intake and the risk of breast cancer. Results: During the mean follow-up of 7.6 years, 145 cases of breast cancer were documented. We found no significant association between the risk of breast cancer and consumption of tofu, boiled beans, and miso soup; the multivariate HRs (95% CI) in the highest category of consumption were 1.14 (0.74-1.77), 0.77 (0.47-1.27) and 1.01 (0.65-1.56), respectively. Only among postmenopausal women, we found no significant associations between soy foods and the risk of breast cancer. Conclusions: This prospective study suggests that consumption of soy food has no protective effects against breast cancer. Further large-scale investigations eliciting genetic factors may clarify different roles of various soybean-ingredient foods on the risk of breast cancer.
AB - Objective: The association between a lower incidence of breast cancer within the Asian population and the consumption of a diet high in soy has recently been the subject of much attention. To examine whether soy foods really have protective effects against breast cancer and how their influence on breast cancer is modified according to menopausal status, we conducted a population-based, prospective cohort study in Japan. Methods: We analyzed the data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 30,454 women aged 40-79 years, completed a questionnaire on diet and other lifestyle features. Hazard ratios (HRs) were computed to examine the association between soy intake and the risk of breast cancer. Results: During the mean follow-up of 7.6 years, 145 cases of breast cancer were documented. We found no significant association between the risk of breast cancer and consumption of tofu, boiled beans, and miso soup; the multivariate HRs (95% CI) in the highest category of consumption were 1.14 (0.74-1.77), 0.77 (0.47-1.27) and 1.01 (0.65-1.56), respectively. Only among postmenopausal women, we found no significant associations between soy foods and the risk of breast cancer. Conclusions: This prospective study suggests that consumption of soy food has no protective effects against breast cancer. Further large-scale investigations eliciting genetic factors may clarify different roles of various soybean-ingredient foods on the risk of breast cancer.
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U2 - 10.1007/s10552-007-9023-7
DO - 10.1007/s10552-007-9023-7
M3 - Article
C2 - 17619154
AN - SCOPUS:34547207113
SN - 0957-5243
VL - 18
SP - 801
EP - 808
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 8
ER -
