Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: A preliminary report

Hidetoshi Shiga, Hiroyuki Hirasawa, Osamu Nishida, Shigeto Oda, Masataka Nakamura, Kunihiro Mashiko, Kenich Matsuda, Nobuya Kitamura, Yoshihiko Kikuchi, Nobuo Fuke

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38 Citations (Scopus)

Abstract

Background/Aim: We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock. Materials and Methods: A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG). Results: Thirty-four patients were enrolled. On ICU admission, the mean blood IL-6 level was 44,800 ± 77,700 pg/ml, and the mean blood lactate level was 69.0 ± 49.4 mg/dl. Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. Though the mean APACHE II score was 32.7 ± 9.8, 28-day survival was 73.5%. Conclusion: The current study suggested that adding AN69ST-CHDF to the treatments outlined in the SSCG might lead to good outcomes for patients with septic shock, probably via the removal of cytokines from the bloodstream.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalBlood Purification
Volume38
Issue number3-4
DOIs
Publication statusPublished - 22-05-2014

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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    Shiga, H., Hirasawa, H., Nishida, O., Oda, S., Nakamura, M., Mashiko, K., Matsuda, K., Kitamura, N., Kikuchi, Y., & Fuke, N. (2014). Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: A preliminary report. Blood Purification, 38(3-4), 211-218. https://doi.org/10.1159/000369377