Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: A preliminary report

Hidetoshi Shiga; Hiroyuki Hirasawa; Osamu Nishida; Shigeto Oda; Masataka Nakamura; Kunihiro Mashiko; Kenich Matsuda; Nobuya Kitamura; Yoshihiko Kikuchi; Nobuo Fuke

doi:10.1159/000369377

Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: A preliminary report

Hidetoshi Shiga, Hiroyuki Hirasawa, Osamu Nishida, Shigeto Oda, Masataka Nakamura, Kunihiro Mashiko, Kenich Matsuda, Nobuya Kitamura, Yoshihiko Kikuchi, Nobuo Fuke

Anesthesiology & Critical Care MedicineⅠ

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Background/Aim: We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock. Materials and Methods: A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG). Results: Thirty-four patients were enrolled. On ICU admission, the mean blood IL-6 level was 44,800 ± 77,700 pg/ml, and the mean blood lactate level was 69.0 ± 49.4 mg/dl. Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. Though the mean APACHE II score was 32.7 ± 9.8, 28-day survival was 73.5%. Conclusion: The current study suggested that adding AN69ST-CHDF to the treatments outlined in the SSCG might lead to good outcomes for patients with septic shock, probably via the removal of cytokines from the bloodstream.

Original language	English
Pages (from-to)	211-218
Number of pages	8
Journal	Blood Purification
Volume	38
Issue number	3-4
DOIs	https://doi.org/10.1159/000369377
Publication status	Published - 22-05-2014

All Science Journal Classification (ASJC) codes

Hematology
Nephrology

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title = "Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: A preliminary report",

abstract = "Background/Aim: We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock. Materials and Methods: A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG). Results: Thirty-four patients were enrolled. On ICU admission, the mean blood IL-6 level was 44,800 ± 77,700 pg/ml, and the mean blood lactate level was 69.0 ± 49.4 mg/dl. Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. Though the mean APACHE II score was 32.7 ± 9.8, 28-day survival was 73.5%. Conclusion: The current study suggested that adding AN69ST-CHDF to the treatments outlined in the SSCG might lead to good outcomes for patients with septic shock, probably via the removal of cytokines from the bloodstream.",

author = "Hidetoshi Shiga and Hiroyuki Hirasawa and Osamu Nishida and Shigeto Oda and Masataka Nakamura and Kunihiro Mashiko and Kenich Matsuda and Nobuya Kitamura and Yoshihiko Kikuchi and Nobuo Fuke",

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doi = "10.1159/000369377",

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T2 - A preliminary report

AU - Shiga, Hidetoshi

AU - Hirasawa, Hiroyuki

AU - Nishida, Osamu

AU - Oda, Shigeto

AU - Nakamura, Masataka

AU - Mashiko, Kunihiro

AU - Matsuda, Kenich

AU - Kitamura, Nobuya

AU - Kikuchi, Yoshihiko

AU - Fuke, Nobuo

PY - 2014/5/22

Y1 - 2014/5/22

N2 - Background/Aim: We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock. Materials and Methods: A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG). Results: Thirty-four patients were enrolled. On ICU admission, the mean blood IL-6 level was 44,800 ± 77,700 pg/ml, and the mean blood lactate level was 69.0 ± 49.4 mg/dl. Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. Though the mean APACHE II score was 32.7 ± 9.8, 28-day survival was 73.5%. Conclusion: The current study suggested that adding AN69ST-CHDF to the treatments outlined in the SSCG might lead to good outcomes for patients with septic shock, probably via the removal of cytokines from the bloodstream.

AB - Background/Aim: We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock. Materials and Methods: A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG). Results: Thirty-four patients were enrolled. On ICU admission, the mean blood IL-6 level was 44,800 ± 77,700 pg/ml, and the mean blood lactate level was 69.0 ± 49.4 mg/dl. Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. Though the mean APACHE II score was 32.7 ± 9.8, 28-day survival was 73.5%. Conclusion: The current study suggested that adding AN69ST-CHDF to the treatments outlined in the SSCG might lead to good outcomes for patients with septic shock, probably via the removal of cytokines from the bloodstream.

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Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: A preliminary report

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